Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection

Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

(2016) Pol Sanllehí et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases

(2016) Mohd Arish et al.   DRUG DISCOVERY TODAY

Exit Strategies: S1P Signaling and T Cell Migration

(2015) Audrey Baeyens et al.   TRENDS IN IMMUNOLOGY

Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning

(2014) Molly E. Ogle et al.   Acta Biomaterialia

Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

(2014) Werner G. Purschke et al.   BIOCHEMICAL JOURNAL

TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate

(2014) Shiori Ito et al.   CORONARY ARTERY DISEASE

S1P-Dependent Trafficking of Intracellular Yersinia pestis through Lymph Nodes Establishes Buboes and Systemic Infection

(2014) Ashley L. St. John et al.   IMMUNITY

Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer's Patches for Intestinal IgA Responses

(2014) M. Gohda et al.   JOURNAL OF IMMUNOLOGY

Sphingosine-1-phosphate Receptor Agonism ReducesBordetella pertussis–mediated Lung Pathology

(2014) Ciaran Skerry et al.   JOURNAL OF INFECTIOUS DISEASES

Animal Model of Respiratory Syncytial Virus: CD8+ T Cells Cause a Cytokine Storm That Is Chemically Tractable by Sphingosine-1-Phosphate 1 Receptor Agonist Therapy

(2014) K. B. Walsh et al.   JOURNAL OF VIROLOGY

Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells

(2014) Katrin Schaper et al.   MOLECULAR IMMUNOLOGY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival

(2014) Matthew M. Gestaut et al.   Pharmacological Reports

Sphingosine Kinase 1 and Cancer: A Systematic Review and Meta-Analysis

(2014) Yun Zhang et al.   PLoS One

Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes

(2013) J. C. Mudd et al.   BLOOD

Novel S1P1 Receptor Agonists − Part 3: From Thiophenes to Pyridines

(2013) Martin H. Bolli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

(2013) Gregory T. Kunkel et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Sphingosine Kinase-2 in a Murine Model of Lupus Nephritis

(2013) Ashley J. Snider et al.   PLoS One

Sphingosine Kinase 1 Serves as a Pro-Viral Factor by Regulating Viral RNA Synthesis and Nuclear Export of Viral Ribonucleoprotein Complex upon Influenza Virus Infection

(2013) Young-Jin Seo et al.   PLoS One

Sphingosine kinase 1 regulates measles virus replication

(2013) Madhuvanthi Vijayan et al.   VIROLOGY

Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines

(2013) Maja Malkowska et al.   Virology Journal

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma

(2012) Y. Liu et al.   BLOOD

Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi

(2012) Mariana R. Dominguez et al.   VACCINE

FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells

(2011) Craig T. Wallington-Beddoe et al.   Autophagy

Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

(2011) James W. Antoon et al.   CANCER BIOLOGY & THERAPY

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

Reduction of the Peripheral Blood CD56bright NK Lymphocyte Subset in FTY720-Treated Multiple Sclerosis Patients

(2011) T. A. Johnson et al.   JOURNAL OF IMMUNOLOGY

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

(2011) Andrew J. Kennedy et al.   JOURNAL OF MEDICINAL CHEMISTRY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Experimental Osteoarthritis in Rats Is Attenuated by ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2011) Leo R. Fitzpatrick et al.   PHARMACOLOGY

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase

(2010) Alexander A. Chumanevich et al.   CARCINOGENESIS

FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma

(2010) Q. Liu et al.   CLINICAL CANCER RESEARCH

Dexamethasone Synergizes with Lenalidomide to Inhibit Multiple Myeloma Tumor Growth, But Reduces Lenalidomide-Induced Immunomodulation of T and NK Cell Function

(2010) A. K. Gandhi et al.   CURRENT CANCER DRUG TARGETS

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine 1-Phosphate-Metabolizing Enzymes Control Influenza Virus Propagation and Viral Cytopathogenicity

(2010) Y.-J. Seo et al.   JOURNAL OF VIROLOGY

Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells

(2010) Joo Hyun Nam et al.   MOLECULES AND CELLS

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death

(2009) Peter M. Voorhees et al.   BRITISH JOURNAL OF HAEMATOLOGY

FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release

(2009) Johannes Rolin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies

(2009) Nicole O'Brien et al.   JOURNAL OF LIPID RESEARCH

FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration

(2009) Su Jin Hwang et al.   LABORATORY INVESTIGATION

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis

(2008) Qing-Fang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF B-inducing kinase in stromal cells

(2008) J. Kunisawa et al.   BLOOD

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye

(2008) James S. Swaney et al.   EXPERIMENTAL EYE RESEARCH

Human Cytomegalovirus Regulates Bioactive Sphingolipids

(2008) Nicholas J. Machesky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor- B pathways in subtypes of diffuse large B-cell lymphoma

(2007) L. T. Lam et al.   BLOOD