Recent advances in understanding nuclear size and shape

Squish and squeeze — the nucleus as a physical barrier during migration in confined environments

(2016) Alexandra Lynn McGregor et al.   CURRENT OPINION IN CELL BIOLOGY

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

(2015) Lena A. Lautscham et al.   BIOPHYSICAL JOURNAL

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions

(2015) Fabian Grubert et al.   CELL

Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping

(2015) Sigal Shachar et al.   CELL

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

(2015) Sebastian M. Waszak et al.   CELL

Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C

(2015) Tsung-Han S. Hsieh et al.   CELL

Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions

(2015) Darío G. Lupiáñez et al.   CELL

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

(2015) Ya Guo et al.   CELL

The Role of Chromosome Domains in Shaping the Functional Genome

(2015) Tom Sexton et al.   CELL

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Nuclear Size Scaling during Xenopus Early Development Contributes to Midblastula Transition Timing

(2015) Predrag Jevtić et al.   CURRENT BIOLOGY

Scaling, Selection, and Evolutionary Dynamics of the Mitotic Spindle

(2015) Reza Farhadifar et al.   CURRENT BIOLOGY

A Comparative Analysis of Spindle Morphometrics across Metazoans

(2015) Marina E. Crowder et al.   CURRENT BIOLOGY

Wash Interacts with Lamin and Affects Global Nuclear Organization

(2015) Jeffrey M. Verboon et al.   CURRENT BIOLOGY

Inverse Size Scaling of the Nucleolus by a Concentration-Dependent Phase Transition

(2015) Stephanie C. Weber et al.   CURRENT BIOLOGY

Dynein-Based Accumulation of Membranes Regulates Nuclear Expansion in Xenopus laevis Egg Extracts

(2015) Yuki Hara et al.   DEVELOPMENTAL CELL

Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening

(2015) Andrew B. Lane et al.   DEVELOPMENTAL CELL

RAD18 Is a Maternal Limiting Factor Silencing the UV-Dependent DNA Damage Checkpoint in Xenopus Embryos

(2015) Chames Kermi et al.   DEVELOPMENTAL CELL

Nuclear Pore Basket Proteins Are Tethered to the Nuclear Envelope and Can Regulate Membrane Curvature

(2015) Noémi Mészáros et al.   DEVELOPMENTAL CELL

A negative loop within the nuclear pore complex controls global chromatin organization

(2015) Manuel Breuer et al.   GENES & DEVELOPMENT

Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins

(2015) Sandra Vidak et al.   GENES & DEVELOPMENT

Histone modifications predispose genome regions to breakage and translocation

(2015) Bharat Burman et al.   GENES & DEVELOPMENT

Mitotic chromosome length scales in response to both cell and nuclear size

(2015) Anne-Marie Ladouceur et al.   JOURNAL OF CELL BIOLOGY

Proliferation-dependent positioning of individual centromeres in the interphase nucleus of human lymphoblastoid cell lines

(2015) Jean Ollion et al.   MOLECULAR BIOLOGY OF THE CELL

SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

(2015) Sergio A. Mojica et al.   MOLECULAR BIOLOGY OF THE CELL

Lamins position the nuclear pores and centrosomes by modulating dynein

(2015) Yuxuan Guo et al.   MOLECULAR BIOLOGY OF THE CELL

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

(2015) Mahito Sadaie et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of lamin B–regulated chromatin regions based on chromatin landscapes

(2015) Xiaobin Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import

(2015) Michael J. W. VanGompel et al.   MOLECULAR BIOLOGY OF THE CELL

Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing

(2015) Li Li et al.   MOLECULAR CELL

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

ESCRT-III controls nuclear envelope reformation

(2015) Yolanda Olmos et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

(2015) Brian D. Freibaum et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Histone titration against the genome sets the DNA-to-cytoplasm threshold for theXenopusmidblastula transition

(2015) Amanda A. Amodeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

The Yeast Polo Kinase Cdc5 Regulates the Shape of the Mitotic Nucleus

(2014) Alison D. Walters et al.   CURRENT BIOLOGY

Sizing and shaping the nucleus: mechanisms and significance

(2014) Predrag Jevtić et al.   CURRENT OPINION IN CELL BIOLOGY

cPKC regulates interphase nuclear size duringXenopusdevelopment

(2014) Lisa J. Edens et al.   JOURNAL OF CELL BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Inherited Isolated Dystonia: Clinical Genetics and Gene Function

(2014) William Dauer   Neurotherapeutics

Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum

(2014) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Partners and post-translational modifications of nuclear lamins

(2013) Dan N. Simon et al.   CHROMOSOMA

REEP3/4 Ensure Endoplasmic Reticulum Clearance from Metaphase Chromatin and Proper Nuclear Envelope Architecture

(2013) Anne-Lore Schlaitz et al.   DEVELOPMENTAL CELL

Chromatin-Bound Xenopus Dppa2 Shapes the Nucleus by Locally Inhibiting Microtubule Assembly

(2013) John Z. Xue et al.   DEVELOPMENTAL CELL

Hutchinson–Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates

(2013) Elizabeth A. Booth-Gauthier et al.   Integrative Biology

Control of DNA Replication by the Nucleus/Cytoplasm Ratio inXenopus

(2013) Christopher M. Murphy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin B1 fluctuations have differential effects on cellular proliferation and senescence

(2013) Oliver Dreesen et al.   JOURNAL OF CELL BIOLOGY

RTN4IP1Is Down-Regulated in Thyroid Cancer and Has Tumor-Suppressive Function

(2013) Reza Rahbari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules

(2013) Simone B. Reber et al.   NATURE CELL BIOLOGY

Cytoplasmic Volume Modulates Spindle Size During Embryogenesis

(2013) M. C. Good et al.   SCIENCE

Changes in Cytoplasmic Volume Are Sufficient to Drive Spindle Scaling

(2013) J. Hazel et al.   SCIENCE

Titration of Four Replication Factors Is Essential for the Xenopus laevis Midblastula Transition

(2013) C. Collart et al.   SCIENCE

Mitotic spindle scaling during Xenopus development by kif2a and importin α

(2013) Jeremy D Wilbur et al.   eLife

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

The Budding Yeast Nuclear Envelope Adjacent to the Nucleolus Serves as a Membrane Sink during Mitotic Delay

(2012) Keren L. Witkin et al.   CURRENT BIOLOGY

Organelle Growth Control through Limiting Pools of Cytoplasmic Components

(2012) Nathan W. Goehring et al.   CURRENT BIOLOGY

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

(2012) Aurelia Barascu et al.   EMBO JOURNAL

Widespread plasticity in CTCF occupancy linked to DNA methylation

(2012) H. Wang et al.   GENOME RESEARCH

Shaping the nucleus: Factors and forces

(2012) Alison D. Walters et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Mitochondrial Network Size Scaling in Budding Yeast

(2012) S. M. Rafelski et al.   SCIENCE

Cancer biology and the nuclear envelope: A convoluted relationship

(2012) Jose I. de las Heras et al.   SEMINARS IN CANCER BIOLOGY

Nuclear size regulation: from single cells to development and disease

(2012) Lisa J. Edens et al.   TRENDS IN CELL BIOLOGY

The Structure of the Nuclear Pore Complex

(2011) André Hoelz et al.   Annual Review of Biochemistry

Mechanisms of Intracellular Scaling

(2011) Daniel L. Levy et al.   Annual Review of Cell and Developmental Biology

Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer

(2011) Callinice D Capo-chichi et al.   BMC Medicine

Katanin Contributes to Interspecies Spindle Length Scaling in Xenopus

(2011) Rose Loughlin et al.   CELL

Limiting Amounts of Centrosome Material Set Centrosome Size in C. elegans Embryos

(2011) Markus Decker et al.   CURRENT BIOLOGY

Lamins, laminopathies and disease mechanisms: Possible role for proteasomal degradation of key regulatory proteins

(2011) Veena K Parnaik et al.   JOURNAL OF BIOSCIENCES

A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature

(2011) Matt West et al.   JOURNAL OF CELL BIOLOGY

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

(2011) Catherine Coffinier et al.   MOLECULAR BIOLOGY OF THE CELL

Scaling properties of cell and organelle size

(2011) Yee-Hung M. Chan et al.   Organogenesis

The lamin protein family

(2011) Travis A Dittmer et al.   GENOME BIOLOGY

Nuclear size, nuclear pore number and cell cycle

(2011) Kazuhiro Maeshima et al.   Nucleus

Involvement of the nuclear pore complex in morphology of the plant nucleus

(2011) Kentaro Tamura et al.   Nucleus

Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells

(2011) Thorsten Kolb et al.   Nucleus

Lamins as cancer biomarkers

(2010) Clare R. Foster et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanisms Determining the Morphology of the Peripheral ER

(2010) Yoko Shibata et al.   CELL

A computational model predicts Xenopus meiotic spindle organization

(2010) Rose Loughlin et al.   JOURNAL OF CELL BIOLOGY

Vesicle trafficking maintains nuclear shape inSaccharomyces cerevisiaeduring membrane proliferation

(2010) Micah T. Webster et al.   JOURNAL OF CELL BIOLOGY

The nucleoporin Nup188 controls passage of membrane proteins across the nuclear pore complex

(2010) Gandhi Theerthagiri et al.   JOURNAL OF CELL BIOLOGY

The nuclear envelope at a glance

(2010) K. L. Wilson et al.   JOURNAL OF CELL SCIENCE

Oocytes as an experimental system to analyze the ultrastructure of endogenous and ectopically expressed nuclear envelope components by field-emission scanning electron microscopy

(2010) Reimer Stick et al.   METHODS

Members of the RSC Chromatin-Remodeling Complex Are Required for Maintaining Proper Nuclear Envelope Structure and Pore Complex Localization

(2010) Laura C. Titus et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase

(2010) Kazuhiro Maeshima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nuclear Lamins

(2010) T. Dechat et al.   Cold Spring Harbor Perspectives in Biology

A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

(2009) Junjie Hu et al.   CELL

Two Distinct Repeat Sequences of Nup98 Nucleoporins Characterize Dual Nuclei in the Binucleated Ciliate Tetrahymena

(2009) Masaaki Iwamoto et al.   CURRENT BIOLOGY

Centrosome attachment to the C. elegans male pronucleus is dependent on the surface area of the nuclear envelope

(2009) Marina Meyerzon et al.   DEVELOPMENTAL BIOLOGY

Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo

(2009) Daniel J. Anderson et al.   JOURNAL OF CELL BIOLOGY

Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans

(2009) M. Gorjanacz et al.   JOURNAL OF CELL SCIENCE

Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope

(2009) A. Golden et al.   JOURNAL OF CELL SCIENCE

Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly

(2009) M. Webster et al.   JOURNAL OF CELL SCIENCE

Circulating Lamin B1 (LMNB1) Biomarker Detects Early Stages of Liver Cancer in Patients

(2009) Stella Sun et al.   JOURNAL OF PROTEOME RESEARCH

Loss of GATA6 Leads to Nuclear Deformation and Aneuploidy in Ovarian Cancer

(2009) C. D. Capo-chichi et al.   MOLECULAR AND CELLULAR BIOLOGY

Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

(2009) Genny Orso et al.   NATURE

Primary dystonia: molecules and mechanisms

(2009) Lauren M. Tanabe et al.   Nature Reviews Neurology

Using gene expression profiling to identify a prognostic molecular spectrum in gliomas

(2008) Mitsuaki Shirahata et al.   CANCER SCIENCE

Evidence for an Upper Limit to Mitotic Spindle Length

(2008) Martin Wühr et al.   CURRENT BIOLOGY

The LINC-less granulocyte nucleus

(2008) Ada L. Olins et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation

(2008) Daniel J. Anderson et al.   JOURNAL OF CELL BIOLOGY

Filaments made from A- and B-type lamins differ in structure and organization

(2008) M. W. Goldberg et al.   JOURNAL OF CELL SCIENCE

The Supramolecular Organization of the C. elegans Nuclear Lamin Filament

(2008) Kfir Ben-Harush et al.   JOURNAL OF MOLECULAR BIOLOGY

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Structure, dynamics and function of nuclear pore complexes

(2008) Maximiliano A. D’Angelo et al.   TRENDS IN CELL BIOLOGY