Article
Cell Biology
M. Crespo, D. A. Leon-Navarro, M. Martin
Summary: Febrile seizures in children can lead to epilepsy in adults, with glutamate playing a key role in the development of neurological disorders. In the short term after seizures, GLT-1 levels increase and glutamate concentration decreases, while mGlu(5)R levels remain unchanged. However, in the long term, an increase in mGlu(5)R levels and decreases in GLT-1 and glutamate levels are observed, associated with the development of an anxious phenotype and potentially increased vulnerability to epileptic events in adults.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Sakiko Taniguchi, Jacob R. Stolz, Geoffrey T. Swanson
Summary: Perampanel (PMP) has been found to inhibit both AMPAR and KARs, suggesting that its clinical actions may arise from selective inhibition of different glutamate receptor signaling pathways.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Falko Lange, Julia Hoernschemeyer, Timo Kirschstein
Summary: The progression of glioblastomas and tumor-associated epilepsy is closely linked through various pathophysiological mechanisms involving the neurotransmitter glutamate. Current research focuses on the role of glutamate receptors in these diseases and discusses future interventions to interfere with the glutamatergic network.
Article
Cell Biology
Kexin Li, Meng Lu, Mengxu Cui, Xiaoming Wang, Yang Zheng
Summary: This study investigated the changes in NAAG, Glu, and mGluR expression, as well as the effects on synaptic plasticity in the brain after HI injury. The results showed an increase in NAAG and mGluR3 expression levels after HI, with a correlation between Glu content and mGluR1/mGluR5 expression. NAAG was found to maintain cortical synaptic plasticity and neurotransmitter homeostasis. Hibernated NAAG levels after 12-24 h of HI injury were associated with mGluR3 receptor expression, thus indicating their role in preserving synaptic function.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Neurosciences
Anna Bodzeta, Nicky Scheefhals, Harold D. MacGillavry
Summary: The various functions of glutamate in the brain are mediated by ionotropic and metabotropic glutamate receptors, which modulate synaptic transmission and plasticity. mGluRs play roles at both presynaptic and postsynaptic sites, acting as essential signal integrators that couple mechanisms of transmission and plasticity.
Review
Clinical Neurology
Roghayeh Mozafari, Saeideh Karimi-Haghighi, Mojdeh Fattahi, Peter Kalivas, Abbas Haghparast
Summary: Psychostimulant Use Disorder is a chronic relapsing disorder with high motivation for drug abuse and is associated with various physical and mental health issues. There is currently no FDA-approved medication for treating psychostimulant abuse, making it crucial to understand the cellular and molecular changes involved in the disorder for developing effective medications.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Neurosciences
Jeremy M. Henley, Jithin D. Nair, Richard Seager, Busra P. Yucel, Gavin Woodhall, Benjamin S. Henley, Karolina Talandyte, Hope I. Needs, Kevin A. Wilkinson
Summary: Epilepsy is caused by abnormal neuronal network activity. The review focuses on the role and regulation of kainate and AMPA receptors in seizure activity, discussing the impact of GluK2 and GluA2 subunits on their respective receptors' properties.
Article
Neurosciences
Yong Liu, You Wang, Juan Yang, Tao Xu, Changhong Tan, Peng Zhang, Qiankun Liu, Yangmei Chen
Summary: The study identified that GIPC1 is downregulated in patients with epilepsy and mice with induced epilepsy, and it interacts with mGluR7 to regulate epileptogenesis by increasing mGluR7 expression.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Pamela R. Westmark, Beatrice Garrone, Rosella Ombrato, Claudio Milanese, Francesco Paolo Di Giorgio, Cara J. Westmark
Summary: This study tested three different GSK3 inhibitors in a FXS mouse model, demonstrating differential effects on susceptibility to audiogenic-induced seizures, dendritic expression of amyloid-beta protein precursor, and dendritic spine length and density.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Martina Tallarico, Antonio Leo, Emilio Russo, Rita Citraro, Ernesto Palma, Giovambattista De Sarro
Summary: Autism spectrum disorders (ASDs) and epilepsy show a bidirectional link, possibly through common neurobiological pathways. BTBR mice have increased susceptibility to seizures induced by chemoconvulsants impairing GABA(A) neurotransmission, while there is no significant difference for seizures induced by AMPA, NMDA, and Kainate. PTZ-kindling does not affect autistic-like behavior in BTBR mice but can increase anxiety and worsen cognitive performance. This suggests a tight connection between ASD and epilepsy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Ruth C. Werthmann, Manuel Tzouros, Jens Lamerz, Angelique Augustin, Thorsten Fritzius, Luca Trovo, Michal Stawarski, Adi Raveh, Catherine Diener, Christophe Fischer, Martin Gassmann, Lothar Lindemann, Bernhard Bettler
Summary: Recent studies have shown that mGlu1 and mGlu5 form functional heterodimers in the brain, exhibiting symmetric signal transduction where both protomers need to reach an active conformation for full receptor activity. This highlights differences in the signaling transduction of heterodimeric mGluRs that influence allosteric modulation.
Article
Neurosciences
Prachi Ojha, Subhajit Pal, Samarjit Bhattacharyya
Summary: Norbin protein plays a critical role in the internalization process of Group I mGluRs and may be associated with mGluR-mediated synaptic plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Giselle Fernandes, Pradeep K. Mishra, Mohammad Sarfaraz Nawaz, Paul G. Donlin-Asp, Mohammed Mostafizur Rahman, Anupam Hazra, Sonal Kedia, Aiman Kayenaat, Dheeraj Songara, David J. A. Wyllie, Erin M. Schuman, Peter C. Kind, Sumantra Chattarji
Summary: In a rat model of Fragile X syndrome (FXS), it was observed that activation rather than inhibition of mGluRs in the basolateral amygdala reversed impairments in fear learning. Activation of presynaptic mGluR5 in the amygdala reversed deficient synaptic transmission and plasticity, restoring normal fear learning in FXS rats. This highlights the importance of considering circuit-specific differences in FXS pathophysiology when developing therapeutic strategies.
Review
Clinical Neurology
Osama Khojah, Seraj Makkawi, Saeed Alghamdi
Summary: This study aimed to systematically review reported cases of anti-mGluR1 encephalitis and summarize their clinical presentation, management, outcomes, and case reports. The study found that anti-mGluR1 encephalitis manifests as symptoms of cerebellar pathology, and early diagnosis with prompt initiation of immunotherapy is crucial for patient recovery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale
Summary: Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were found to selectively positively modulate metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no cross-reactivity at mGluR1a, mGluR5, or mGluR8. Additional analogs were prepared to increase binding affinity, resulting in successful selective lateral metalation and electrophilic quenching at the C3 position.
Article
Neurosciences
Clotilde Balucani, Riccardo Bianchi, Charles Ramkishun, Jeremy Weedon, Susan Law, Michael Szarek, Diana Rojas-Soto, Sara Tariq, Steven R. Levine
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2015)
Article
Clinical Neurology
Clotilde Balucani, Riccardo Bianchi, Edward Feldmann, Jeremy Weedon, Dmitri Kolychev, Steven R. Levine
Article
Neurosciences
Clotilde Balucani, Riccardo Bianchi, Charles Ramkishun, Jeremy Weedon, Susan Law, Michael Szarek, Diana Rojas-Soto, Sara Tariq, Steven R. Levine
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2015)
Article
Geriatrics & Gerontology
Syed F. Kazim, Shih-Chieh Chuang, Wangfa Zhao, Robert K. S. Wong, Riccardo Bianchi, Khalid Iqbal
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Clinical Neurology
Steven R. Levine, Sarah Z. Weingast, Jeremy Weedon, Dimitre G. Stefanov, Patricia Katz, Dana Hurley, Scott E. Kasner, Pooja Khatri, Joseph P. Broderick, James C. Grotta, Edward Feldmann, Peter D. Panagos, Jose G. Romano, Riccardo Bianchi, Brett C. Meyer, Phillip A. Scott, Doojin Kim, Clotilde Balucani
Article
Cell Biology
Ilham A. Muslimov, Aliya Tuzhilin, Thean Hock Tang, Robert K. S. Wong, Riccardo Bianchi, Henri Tiedge
JOURNAL OF CELL BIOLOGY
(2014)
Article
Neurosciences
Steven R. Young, Shih-Chieh Chuang, Wangfa Zhao, Robert K. S. Wong, Riccardo Bianchi
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Emily K. Osterweil, Shih-Chieh Chuang, Alexander A. Chubykin, Michael Sidorov, Riccardo Bianchi, Robert K. S. Wong, Mark F. Bear
Article
Multidisciplinary Sciences
Syed Faraz Kazim, Julie Blanchard, Riccardo Bianchi, Khalid Iqbal
SCIENTIFIC REPORTS
(2017)
Review
Neurosciences
Syed Faraz Kazim, Joon Ho Seo, Riccardo Bianchi, Chloe S. Larson, Abhijeet Sharma, Robert K. S. Wong, Kirill Y. Gorbachev, Ana C. Pereira
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, with recent evidence suggesting that network abnormalities may play a key role in cognitive decline. A beta and tau are implicated in inducing network hyperexcitability, with genetic mutations leading to increased A beta production and hyperphosphorylated tau accumulation associated with seizures and epilepsy in patients. This review discusses the common and distinct roles of tau and A beta in neuronal hyperexcitability in Alzheimer's disease, proposing hypotheses for future experiments.
Article
Emergency Medicine
Benjamin H. Schnapp, Al'ai Alvarez, Riccardo Bianchi, Holly Caretta-Weyer, Corlin Jewell, Annahieta Kalantari, Eric Lee, Danielle Miller, Antonia Quinn
Summary: For residency recruitment, transparency with selection criteria, holistic application review, standardized letters of evaluation, and blinding applicant files for interviewers are considered some of the best practices.
AEM EDUCATION AND TRAINING
(2021)
Meeting Abstract
Clinical Neurology
Clotilde Balucani, Sarah Z. Weingast, Jeremy Weedon, Dimitre G. Stefanov, Patricia Katz, Dana Hurley, Pooja Khatri, Joseph P. Broderick, Scott E. Kasner, James C. Grotta, Edward Feldmann, Peter D. Panagos, Jose G. Romano, Riccardo Bianchi, Brett C. Meyer, Phillip A. Scott, Doojin Kim, Steven R. Levine
Meeting Abstract
Clinical Neurology
Clotilde Balucani, Riccardo Bianchi, Jeremy Weedon, Steven Levine
Review
Medicine, General & Internal
Mario Ciampolini, H. David Lovell-Smith, Timothy Kenealy, Riccardo Bianchi
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2013)