Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain

Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification

(2015) Jing Zhao et al.   eLife

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

(2014) King-Hwa Ling et al.   BMC GENOMICS

Analysis of Adult Cerebral Cortex and Hippocampus Transcriptomes Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome

(2014) Faycal Guedj et al.   BRAIN PATHOLOGY

STAT3 but Not STAT1 Is Required for Astrocyte Differentiation

(2014) Seulgi Hong et al.   PLoS One

Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

(2014) Chen Chen et al.   Nature Communications

Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors

(2013) Woondong Jeong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Down Syndrome: Genes, Model Systems, and Progress towards Pharmacotherapies and Clinical Trials for Cognitive Deficits

(2013) J. Busciglio et al.   CYTOGENETIC AND GENOME RESEARCH

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis

(2013) Donna M Wilcock et al.   Journal of Neuroinflammation

Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease

(2013) Juliet M. Taylor et al.   NEUROBIOLOGY OF AGING

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Type I interferons impair BDNF-induced cell signaling and neurotrophic activity in differentiated human SH-SY5Y neuroblastoma cells and mouse primary cortical neurons

(2012) Simona Dedoni et al.   JOURNAL OF NEUROCHEMISTRY

Interferon Gamma and Sonic Hedgehog Signaling Are Required to Dysregulate Murine Neural Stem/Precursor Cells

(2012) Janine Walter et al.   PLoS One

Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology

(2012) James A. Briggs et al.   STEM CELLS

A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway

(2011) Y. Zheng et al.   BLOOD

Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway

(2011) Marta Sidoryk-Wegrzynowicz et al.   GLIA

ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon

(2010) T. Hornakova et al.   BLOOD

Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia

(2010) R. C. Harvey et al.   BLOOD

Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

(2010) Sandra Guidi et al.   BRAIN PATHOLOGY

Locked Nucleic Acids: Promising Nucleic Acid Analogs for Therapeutic Applications

(2010) Rakesh N. Veedu et al.   CHEMISTRY & BIODIVERSITY

Astrocytes and Synaptic Plasticity

(2010) Alison J. Barker et al.   NEUROSCIENTIST

Interferon-γ Produced by Microglia and the Neuropeptide PACAP Have Opposite Effects on the Viability of Neural Progenitor Cells

(2010) Johanna Mäkelä et al.   PLoS One

Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

(2010) Chelsee A. Hewitt et al.   PLoS One

Differential Regulation of Proliferation and Differentiation in Neural Precursor Cells by the Jak Pathway

(2010) Yun Hee Kim et al.   STEM CELLS

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

(2009) Masakazu Namihira et al.   DEVELOPMENTAL CELL

Down syndrome--recent progress and future prospects

(2009) F. K. Wiseman et al.   HUMAN MOLECULAR GENETICS

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

(2009) Yusuke Hirabayashi et al.   NEURON

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

(2009) A. Yoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating mutations in human acute megakaryoblastic leukemia

(2008) S. Malinge et al.   BLOOD

Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia

(2008) L. Kearney et al.   BLOOD

Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome

(2008) Tomohiko Sato et al.   BRITISH JOURNAL OF HAEMATOLOGY

IFNγ signaling—Does it mean JAK–STAT?

(2008) Daniel J. Gough et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia

(2008) Elisabetta Flex et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

(2008) Dani Bercovich et al.   LANCET