Paramyxovirus V Proteins Interact with the RNA Helicase LGP2 To Inhibit RIG-I-Dependent Interferon Induction

Pathogen Recognition by the Innate Immune System

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The Measles Virus V Protein Binds to p65 (RelA) To Suppress NF- B Activity

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Identification of Human Parainfluenza Virus Type 2 (HPIV-2) V Protein Amino Acid Residues That Reduce Binding of V to MDA5 and Attenuate HPIV-2 Replication in Nonhuman Primates

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Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

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Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist

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Pattern recognition of viral nucleic acids by RIG-I-like helicases

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The C Proteins of Human Parainfluenza Virus Type 1 Limit Double-Stranded RNA Accumulation That Would Otherwise Trigger Activation of MDA5 and Protein Kinase R

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Dissociation of Paramyxovirus Interferon Evasion Activities: Universal and Virus-Specific Requirements for Conserved V Protein Amino Acids in MDA5 Interference

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Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

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Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate

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Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterocellular induction of interferon by negative-sense RNA viruses

(2010) S. Chen et al.   VIROLOGY

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

(2010) Leonid Gitlin et al.   PLoS Pathogens

Crystallization and preliminary crystallographic studies of human RIG-I in complex with double-stranded RNA

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Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

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RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

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Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains

(2009) Kiyohiro Takahasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2

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The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

(2009) Xiaojun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both RIG-I and MDA5 RNA Helicases Contribute to the Induction of Alpha/Beta Interferon in Measles Virus-Infected Human Cells

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A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2

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Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

(2009) A. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Select Paramyxoviral V Proteins Inhibit IRF3 Activation by Acting as Alternative Substrates for Inhibitor of κB Kinase ϵ (IKKe)/TBK1

(2008) Lenette L. Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of LGP2, a DEX(D/H) Helicase That Regulates the Innate Immunity Response

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Measles Virus Circumvents the Host Interferon Response by Different Actions of the C and V Proteins

(2008) Y. Nakatsu et al.   JOURNAL OF VIROLOGY

Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins

(2008) K. S. Childs et al.   JOURNAL OF VIROLOGY

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY