Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis

Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53

(2015) Y Zhao et al.   CELL DEATH AND DIFFERENTIATION

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

(2015) Yan Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

(2015) Xuetian Yue et al.   eLife

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway

(2015) Xiaoyan Li et al.   Oncotarget

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

(2015) Juan Liu et al.   Oncotarget

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

(2014) Milos Galic et al.   eLife

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

(2013) Tongsen Zheng et al.   Nature Communications

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

(2012) K. Thangavelu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Outcome and survival analysis of pulmonary metastasectomy for hepatocellular carcinoma

(2011) K. Kitano et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis

(2010) E. E. Bosco et al.   BLOOD

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Rac1 Is Essential for Basement Membrane-Dependent Epiblast Survival

(2010) X. He et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation of the GTPase Rac1 is required for optimal cell migration

(2010) Sonia Castillo-Lluva et al.   NATURE CELL BIOLOGY

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY