The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease

(2016) Olav M. Andersen et al.   ACTA NEUROPATHOLOGICA

Role of lipoprotein lipase in lipid metabolism

(2016) Gunilla Olivecrona   CURRENT OPINION IN LIPIDOLOGY

Regulation of lipid metabolism by angiopoietin-like proteins

(2016) Wieneke Dijk et al.   CURRENT OPINION IN LIPIDOLOGY

Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis

(2016) María José Ariza et al.   Journal of Clinical Lipidology

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

(2016) Wieneke Dijk et al.   JOURNAL OF LIPID RESEARCH

Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease

(2016) Anna Helgadottir et al.   NATURE GENETICS

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

GPIHBP1 and Plasma Triglyceride Metabolism

(2016) Loren G. Fong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

(2016) Simon Mysling et al.   eLife

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

(2015) James A. Irving et al.   BIOCHEMICAL JOURNAL

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

(2015) Viktoria Gusarova et al.   JOURNAL OF LIPID RESEARCH

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

(2015) Yan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

(2015) Wieneke Dijk et al.   eLife

The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries

(2014) Chris N. Goulbourne et al.   Cell Metabolism

Negatively-charged helices in the gas phase

(2014) Andrew R. Johnson et al.   CHEMICAL COMMUNICATIONS

Multimerization of Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1) and Familial Chylomicronemia from a Serine-to-Cysteine Substitution in GPIHBP1 Ly6 Domain

(2014) Wanee Plengpanich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets

(2013) Mikael Larsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase

(2013) Michael J. Lafferty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Analyses of Lipoprotein Lipase, Hepatic Lipase, and Endothelial Lipase, and Their Binding Properties with Known Inhibitors

(2013) Ziyun Wang et al.   PLoS One

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed

(2012) Elena Makoveichuk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4

(2012) Stefan K. Nilsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase

(2012) Terje Robal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking

(2011) S. C. Klinger et al.   JOURNAL OF CELL SCIENCE

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk

(2010) Melissa C. Smart-Halajko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

(2010) Brandon S.J. Davies et al.   Cell Metabolism

Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

(2009) Anne P. Beigneux et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

(2009) E-Chiang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Highly Conserved Motif within the NH2-terminal Coiled-coil Domain of Angiopoietin-like Protein 4 Confers Its Inhibitory Effects on Lipoprotein Lipase by Disrupting the Enzyme Dimerization

(2009) Ming-hon Yau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function

(2009) Wu Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

(2009) William K. Sonnenburg et al.   JOURNAL OF LIPID RESEARCH

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

(2009) Marius R. Robciuc et al.   JOURNAL OF LIPID RESEARCH

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia

(2009) Gunilla Olivecrona et al.   JOURNAL OF LIPID RESEARCH

The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms

(2008) Lu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

(2008) Anne P. Beigneux et al.   JOURNAL OF LIPID RESEARCH