An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

(2014) James A. Irving et al.   BIOCHEMICAL JOURNAL

A Cryo-Electron Microscopy Study Identifies the Complete H16.V5 Epitope and Reveals Global Conformational Changes Initiated by Binding of the Neutralizing Antibody Fragment

(2014) Hyunwook Lee et al.   JOURNAL OF VIROLOGY

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

(2013) Imran Haq et al.   BIOSCIENCE REPORTS

The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α1-Antitrypsin

(2013) Anja S. Knaupp et al.   PLoS One

The stability of 2-state, 3-state and more-state proteins from simple spectroscopic techniques... plus the structure of the equilibrium intermediates at the same time

(2012) Javier Sancho   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency

(2012) Adriana Ordóñez et al.   HEPATOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

(2012) Mun Peak Nyon et al.   STRUCTURE

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

(2011) Aftabul Haque et al.   CELL

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

(2011) Masayuki Yamasaki et al.   EMBO REPORTS

Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization

(2011) Beena Krishnan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thermodynamic Analysis of Ligand-Induced Changes in Protein Thermal Unfolding Applied to High-Throughput Determination of Ligand Affinities with Extrinsic Fluorescent Dyes

(2010) Curtis J. Layton et al.   BIOCHEMISTRY

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with α1-antitrypsin deficiency

(2010) Elena Miranda et al.   HEPATOLOGY

Effects of glycosylation on the stability and flexibility of a metastable protein: The human serpin α1-antitrypsin

(2010) Anindya Sarkar et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Defining the mechanism of polymerization in the serpinopathies

(2010) U. I. Ekeowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleaved antitrypsin polymers at atomic resolution

(2010) Michelle A. Dunstone et al.   PROTEIN SCIENCE

Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

(2010) Wun-Shaing W. Chang et al.   PROTEIN SCIENCE

Mechanisms of emphysema in  1-antitrypsin deficiency: molecular and cellular insights

(2009) B. Gooptu et al.   EUROPEAN RESPIRATORY JOURNAL

Kinetic Instability of the Serpin Z α1-Antitrypsin Promotes Aggregation

(2009) Anja S. Knaupp et al.   JOURNAL OF MOLECULAR BIOLOGY

Liver Disease in Alpha 1-Antitrypsin Deficiency: A Review

(2008) Kyrsten D. Fairbanks et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Structural Basis of Serpin Polymerization Studied by Hydrogen/Deuterium Exchange and Mass Spectrometry

(2008) Yuko Tsutsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE