The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine

Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure–activity relationship and unique pyrrolylation of primary amines

(2015) Ramesh Dasari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties

(2015) Natália Bueno Leite et al.   BIOPHYSICAL JOURNAL

5′-O-Alkylpyridoxamines: Lipophilic Analogues of Pyridoxamine Are Potent Scavengers of 1,2-Dicarbonyls

(2015) Venkataraman Amarnath et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Scavenging 4-Oxo-2-nonenal

(2015) Venkataraman Amarnath et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Know your target, know your molecule

(2015) Mark E Bunnage et al.   Nature Chemical Biology

Functional genomics to uncover drug mechanism of action

(2015) Sebastian M B Nijman   Nature Chemical Biology

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium

(2015) Jason H. Stafford et al.   NEOPLASIA

Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

(2014) Qingcheng Mao et al.   AAPS Journal

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells

(2014) Yegor Smurnyy et al.   Nature Chemical Biology

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity

(2013) MARINA BURY et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

(2013) Vishal M. Gohil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The why and how of phenotypic small-molecule screens

(2013) Ulrike S Eggert   Nature Chemical Biology

Target identification and mechanism of action in chemical biology and drug discovery

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

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Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity

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Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells

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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

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The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1

(2012) Susanna Bodoy et al.   MOLECULAR ASPECTS OF MEDICINE

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

(2012) Kivanç Birsoy et al.   NATURE GENETICS

Membrane-active host defense peptides – Challenges and perspectives for the development of novel anticancer drugs

(2011) Sabrina Riedl et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Phosphatidylethanolamines Modified by γ-Ketoaldehyde (γKA) Induce Endoplasmic Reticulum Stress and Endothelial Activation

(2011) Lilu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

Bugs, drugs and chemical genomics

(2011) Terry Roemer et al.   Nature Chemical Biology

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

(2011) J. H. Reiling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of glycerophospholipid homeostasis in mammalian cells

(2011) Martin Hermansson et al.   PROGRESS IN LIPID RESEARCH

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

(2010) Federica Gibellini et al.   IUBMB LIFE

Isoketals form cytotoxic phosphatidylethanolamine adducts in cells

(2009) C. Blake Sullivan et al.   JOURNAL OF LIPID RESEARCH

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Two Distinct Molecular Mechanisms Underlying Cytarabine Resistance in Human Leukemic Cells

(2008) J. Cai et al.   CANCER RESEARCH

Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes

(2008) Paul A. Grimsrud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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