Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein

Treating osteoporosis

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Comparison of batch and continuous multi-column protein A capture processes by optimal design

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Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production

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The Best. First. Anti-EGFR before anti-VEGF, in the first-line treatment of RAS wild-type metastatic colorectal cancer: from bench to bedside

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Therapeutic potential and critical analysis of trastuzumab and bevacizumab in combination with different chemotherapeutic agents against metastatic breast/colorectal cancer affecting various endpoints

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Targeted Therapeutics in Patients With High-Grade Gliomas: Past, Present, and Future

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Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

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Treatment dilemmas of cetuximab combined with chemotherapy for metastatic colorectal cancer

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Guideline of Chronic Urticaria Beyond

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Comparison of batch and continuous multi-column protein A capture processes by optimal design

(2016) Daniel Baur et al.   Biotechnology Journal

Continuous counter-current chromatography for capture and polishing steps in biopharmaceutical production

(2016) Fabian Steinebach et al.   Biotechnology Journal

Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma

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Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

(2015) Daniel Baur et al.   Biotechnology Journal

Continuous precipitation of IgG from CHO cell culture supernatant in a tubular reactor

(2015) Nikolaus Hammerschmidt et al.   Biotechnology Journal

Obinutuzumab (GA101) compared to rituximab significantly enhances cell death and antibody-dependent cytotoxicity and improves overall survival against CD20+ rituximab-sensitive/-resistant Burkitt lymphoma (BL) and precursor B-acute lymphoblastic leukaemia

(2015) Aradhana Awasthi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Rapid analysis of charge variants of monoclonal antibodies using non-linear salt gradient in cation-exchange high performance liquid chromatography

(2015) Varsha Joshi et al.   JOURNAL OF CHROMATOGRAPHY A

Characterization of cation exchanger stationary phases applied for the separations of therapeutic monoclonal antibodies

(2015) Szabolcs Fekete et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Ion-exchange chromatography for the characterization of biopharmaceuticals

(2015) Szabolcs Fekete et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Oncolytic reovirus enhances rituximab-mediated antibody-dependent cellular cytotoxicity against chronic lymphocytic leukaemia

(2015) C Parrish et al.   LEUKEMIA

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

(2015) Daniel Baur et al.   Biotechnology Journal

Continuous precipitation of IgG from CHO cell culture supernatant in a tubular reactor

(2015) Nikolaus Hammerschmidt et al.   Biotechnology Journal

Semiautomated pH Gradient Ion-Exchange Chromatography of Monoclonal Antibody Charge Variants

(2014) Mohammad Talebi et al.   ANALYTICAL CHEMISTRY

Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation

(2014) Nikolaus Hammerschmidt et al.   Biotechnology Journal

Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality

(2014) Kurt Brorson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range: Validation of the method parameters

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PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

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Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range

(2013) Nico Lingg et al.   JOURNAL OF CHROMATOGRAPHY A

Comparative Assessment of Clinically Utilized CD20-Directed Antibodies in Chronic Lymphocytic Leukemia Cells Reveals Divergent NK Cell, Monocyte, and Macrophage Properties

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Analytical characterization of biosimilar antibodies and Fc-fusion proteins

(2013) Alain Beck et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

(2012) Miranda M. C. van Beers et al.   Biotechnology Journal

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength

(2012) Liangyi Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Assessing monoclonal antibody product quality attribute criticality through clinical studies

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Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative analysis of monoclonal antibodies by cation-exchange chromatofocusing

(2009) Anna Rozhkova   JOURNAL OF CHROMATOGRAPHY A

Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors

(2009) Andrea Bertolotti-Ciarlet et al.   MOLECULAR IMMUNOLOGY

Heterogeneity of Monoclonal Antibodies

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Glycosylation of Recombinant Antibody Therapeutics

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