Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

Defective control of pre–messenger RNA splicing in human disease

(2016) Benoit Chabot et al.   JOURNAL OF CELL BIOLOGY

Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

(2016) Dianne Pham et al.   NATURAL PRODUCT REPORTS

Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy

(2016) Maayan Salton et al.   TRENDS IN MOLECULAR MEDICINE

Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide

(2015) Anaya Raj Pokhrel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells

(2015) Hiroaki Sasaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines

(2015) Bas Heinhuis et al.   CARCINOGENESIS

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

(2015) M. K. Kashyap et al.   HAEMATOLOGICA

Regulación del splicing alternativo: Implicaciones en el diagnóstico y tratamiento del cáncer

(2015) Nancy Martínez-Montiel et al.   MEDICINA CLINICA

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD

(2015) Mitsunori Koga et al.   NUCLEIC ACIDS RESEARCH

“Pruning of biomolecules and natural products (PBNP)”: an innovative paradigm in drug discovery

(2015) Surendar Reddy Bathula et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Human Telomerase RNA Processing and Quality Control

(2015) Chi-Kang Tseng et al.   Cell Reports

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

(2015) M. K. Kashyap et al.   HAEMATOLOGICA

Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves

(2014) Victor P Bagla et al.   BMC Complementary and Alternative Medicine

Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues

(2014) Haiyin He et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives

(2014) Arun K. Ghosh et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of GEX1Q1, Assignment of C-5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity

(2014) Arun K. Ghosh et al.   ORGANIC LETTERS

SnapShot-Seq: A Method for Extracting Genome-Wide, In Vivo mRNA Dynamics from a Single Total RNA Sample

(2014) Jesse M. Gray et al.   PLoS One

Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

(2013) Chandraiah Lagisetti et al.   ACS Chemical Biology

High antitumor activity of pladienolide B and its derivative in gastric cancer

(2013) Momoko Sato et al.   CANCER SCIENCE

A new flavanone and other constituents from the rhizomes of Cyperus rotundus and their antioxidant activities

(2013) Zhongliu Zhou et al.   CHEMISTRY OF NATURAL COMPOUNDS

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

(2013) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

(2013) Xiangyang Liu et al.   JOURNAL OF ANTIBIOTICS

Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

(2013) Xiangyang Liu et al.   JOURNAL OF NATURAL PRODUCTS

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

Enantioselective Syntheses of FR901464 and Spliceostatin A: Potent Inhibitors of Spliceosome

(2013) Arun K. Ghosh et al.   ORGANIC LETTERS

Enantioselective Synthesis of Pladienolide B and Truncated Analogues as New Anticancer Agents

(2013) Vemula Praveen Kumar et al.   ORGANIC LETTERS

Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants

(2013) Jing-Ke Weng et al.   Frontiers in Plant Science

Role of splice variants in the metastatic progression of prostate cancer: Figure 1

(2012) Rachel M. Hagen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Comparison of Splicing Factor 3b Inhibitors in Human Cells

(2012) Yang Gao et al.   CHEMBIOCHEM

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer

(2012) Thomas R. Webb et al.   DRUG DISCOVERY TODAY

The spliceosome as a target of novel antitumour drugs

(2012) Sophie Bonnal et al.   NATURE REVIEWS DRUG DISCOVERY

Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor

(2012) Arun K. Ghosh et al.   ORGANIC LETTERS

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

(2011) Liying Fan et al.   ACS Chemical Biology

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

(2011) Akira Yokoi et al.   FEBS Journal

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

(2011) A. Corrionero et al.   GENES & DEVELOPMENT

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

(2011) E. G. Folco et al.   GENES & DEVELOPMENT

Biflavonoids from Caper (Capparis spinosaL.) Fruits and Their Effects in Inhibiting NF-kappa B Activation

(2011) Hai-Feng Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

(2011) F Damm et al.   LEUKEMIA

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Total Synthesis of (+)-Herboxidiene from Two Chiral Lactate-Derived Ketones

(2011) Miquel Pellicena et al.   ORGANIC LETTERS

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

(2010) Makoto Hasegawa et al.   ACS Chemical Biology

Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464

(2010) Sami Osman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Garbled messages and corrupted translations

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

(2010) Gabriel A. Roybal et al.   NUCLEIC ACIDS RESEARCH

Phytochemical Investigation ofCycas circinalisandCycas revolutaLeaflets: Moderately Active Antibacterial Biflavonoids

(2010) Abeer Moawad et al.   PLANTA MEDICA

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene

(2009) Kazuhiro Machida et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Alternative splicing and disease

(2008) Jamal Tazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The spliceosome as target for anticancer treatment

(2008) R J van Alphen et al.   BRITISH JOURNAL OF CANCER

Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism

(2008) C. R. Cederroth et al.   DIABETES

The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing

(2008) Kristine O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increase in pladienolide D production rate using a Streptomyces strain overexpressing a cytochrome P450 gene

(2008) Kazuhiro Machida et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Total Synthesis of GEX1A

(2008) Timothy J. Murray et al.   ORGANIC LETTERS