Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets
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Title
Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets
Authors
Keywords
Sphingolipids, Sphingosine-1-phosphate, Stroke, Immune modulation
Journal
Translational Stroke Research
Volume 7, Issue 5, Pages 420-438
Publisher
Springer Nature
Online
2016-06-25
DOI
10.1007/s12975-016-0477-3
References
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Note: Only part of the references are listed.- Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides
- (2016) Akio Kihara PROGRESS IN LIPID RESEARCH
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- (2015) Hua Tang et al. Acta Cirurgica Brasileira
- Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE
- (2015) Zilong Zhu et al. CIRCULATION
- Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia
- (2015) Shuli Zheng et al. EXPERIMENTAL NEUROLOGY
- FTY720 attenuates excitotoxicity and neuroinflammation
- (2015) Raffaela Cipriani et al. Journal of Neuroinflammation
- Changes in the metabolism of sphingolipids after subarachnoid hemorrhage
- (2015) Fernando D. Testai et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Sphingolipids in cardiovascular diseases and metabolic disorders
- (2015) Sonia Borodzicz et al. Lipids in Health and Disease
- Immune interventions in stroke
- (2015) Ying Fu et al. Nature Reviews Neurology
- Post-injury administration of allicin attenuates ischemic brain injury through sphingosine kinase 2: In vivo and in vitro studies
- (2015) Jia-Ji Lin et al. NEUROCHEMISTRY INTERNATIONAL
- Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage
- (2015) Kenji Yagi et al. STROKE
- Sphingosine 1-phosphate signaling at the blood–brain barrier
- (2015) Briana Prager et al. TRENDS IN MOLECULAR MEDICINE
- Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke
- (2015) Gab Seok Kim et al. Nature Communications
- Rethinking the Roles of Inflammation in the Intracerebral Hemorrhage
- (2015) Xiao-Yi Xiong et al. Translational Stroke Research
- Microglia/Macrophage Polarization After Experimental Intracerebral Hemorrhage
- (2015) Hao Zhao et al. Translational Stroke Research
- Iron-Induced Necrotic Brain Cell Death in Rats with Different Aerobic Capacity
- (2015) Mingzhe Zheng et al. Translational Stroke Research
- The Pathophysiology of Intracerebral Hemorrhage Formation and Expansion
- (2015) Frieder Schlunk et al. Translational Stroke Research
- Correlating Cerebral 18FDG PET-CT Patterns with Histological Analysis During Early Brain Injury in a Rat Subarachnoid Hemorrhage Model
- (2015) Jianping Song et al. Translational Stroke Research
- Perihematoma Edema: A Potential Translational Target in Intracerebral Hemorrhage?
- (2015) Magdy Selim et al. Translational Stroke Research
- Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment
- (2014) Kazuya Fukumoto et al. BEHAVIOURAL BRAIN RESEARCH
- Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage
- (2014) Lei Lu et al. BRAIN RESEARCH
- Preconditioning Stimuli Induce Autophagy via Sphingosine Kinase 2 in Mouse Cortical Neurons
- (2014) Rui Sheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke
- (2014) Nancy L Monson et al. Journal of Neuroinflammation
- CCR2+Ly6Chi Inflammatory Monocyte Recruitment Exacerbates Acute Disability Following Intracerebral Hemorrhage
- (2014) M. D. Hammond et al. JOURNAL OF NEUROSCIENCE
- Sphingolipid metabolites in inflammatory disease
- (2014) Michael Maceyka et al. NATURE
- Ischemic neurons recruit natural killer cells that accelerate brain infarction
- (2014) Y. Gan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impact of an immune modulator fingolimod on acute ischemic stroke
- (2014) Ying Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance
- (2014) R. Anne Stetler et al. PROGRESS IN NEUROBIOLOGY
- Neuroprotective gases – Fantasy or reality for clinical use?
- (2014) Jiao Deng et al. PROGRESS IN NEUROBIOLOGY
- α4 Integrin Is a Regulator of Leukocyte Recruitment After Experimental Intracerebral Hemorrhage
- (2014) Matthew D. Hammond et al. STROKE
- Fingolimod for the treatment of neurological diseases—state of play and future perspectives
- (2014) Robert Brunkhorst et al. Frontiers in Cellular Neuroscience
- Full Steam Ahead with Remote Ischemic Conditioning for Stroke
- (2014) Richard F. Keep et al. Translational Stroke Research
- Vascular Neural Network in Subarachnoid Hemorrhage
- (2014) John H. Zhang Translational Stroke Research
- Molecular and Cellular Immune Responses to Ischemic Brain Injury
- (2014) Hilary A. Seifert et al. Translational Stroke Research
- Intracerebral Hemorrhage: A Multimodality Approach to Improving Outcome
- (2014) Aditya S. Pandey et al. Translational Stroke Research
- An Update on Inflammation in the Acute Phase of Intracerebral Hemorrhage
- (2014) Sheng Chen et al. Translational Stroke Research
- Hyperglycemia, Acute Ischemic Stroke, and Thrombolytic Therapy
- (2014) Sherif Hafez et al. Translational Stroke Research
- Fingolimod for the Treatment of Intracerebral Hemorrhage
- (2014) Ying Fu et al. JAMA Neurology
- Co-evolution of sphingomyelin and the ceramide transport protein CERT
- (2013) Kentaro Hanada BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition
- (2013) Hyun Jung Byun et al. Biomolecules & Therapeutics
- Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage
- (2013) Roslyn A. Taylor et al. Clinical & Developmental Immunology
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke
- (2013) Sheetal Bodhankar et al. METABOLIC BRAIN DISEASE
- Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice
- (2013) Sheetal Bodhankar et al. METABOLIC BRAIN DISEASE
- Delayed neurological deterioration after subarachnoid haemorrhage
- (2013) R. Loch Macdonald Nature Reviews Neurology
- Clinical relevance of cerebral autoregulation following subarachnoid haemorrhage
- (2013) Karol P. Budohoski et al. Nature Reviews Neurology
- Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons
- (2013) Yukiko Doi et al. PLoS One
- Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation
- (2013) Yu Zhou et al. PROGRESS IN NEUROBIOLOGY
- Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed Tissue Plasminogen Activator Treatment in a Mouse Thromboembolic Model
- (2013) Francisco Campos et al. STROKE
- Hematology and Inflammatory Signaling of Intracerebral Hemorrhage
- (2013) W. C. Ziai STROKE
- FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection
- (2013) Peter Kraft et al. STROKE
- Role of the Sphingosine Metabolism Pathway on Neurons Against Experimental Cerebral Ischemia in Rats
- (2013) Yu Hasegawa et al. Translational Stroke Research
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- Lysophospholipids and their receptors in the central nervous system
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- Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice*
- (2012) Orhan Altay et al. CRITICAL CARE MEDICINE
- Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
- (2012) Sahar A. Saddoughi et al. EMBO Molecular Medicine
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- (2012) William B. Rolland et al. EXPERIMENTAL NEUROLOGY
- Systematic Review and Meta-Analysis of the Efficacy of Sphingosine-1-Phosphate (S1P) Receptor Agonist FTY720 (Fingolimod) in Animal Models of Stroke
- (2012) Junfeng Liu et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Protein Phosphatase 1α Mediates Ceramide-induced ERM Protein Dephosphorylation
- (2012) Daniel Canals et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Junctional Protein Regulation by Sphingosine Kinase 2 Contributes to Blood–Brain Barrier Protection in Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance
- (2012) Bradley K Wacker et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway
- (2012) Bradley K. Wacker et al. JOURNAL OF NEUROCHEMISTRY
- Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
- (2012) Richard F Keep et al. LANCET NEUROLOGY
- Diabetes, hyperglycaemia, and acute ischaemic stroke
- (2012) Merel JA Luitse et al. LANCET NEUROLOGY
- Management of non-traumatic intraventricular hemorrhage
- (2012) Thomas Gaberel et al. NEUROSURGICAL REVIEW
- Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome
- (2012) R. Deogracias et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Changes in the Cerebrospinal Fluid Ceramide Profile After Subarachnoid Hemorrhage
- (2012) Fernando D. Testai et al. STROKE
- Relationship Between Angiographic Vasospasm and Regional Hypoperfusion in Aneurysmal Subarachnoid Hemorrhage
- (2012) Rajat Dhar et al. STROKE
- Isoflurane Attenuates Blood–Brain Barrier Disruption in Ipsilateral Hemisphere After Subarachnoid Hemorrhage in Mice
- (2012) Orhan Altay et al. STROKE
- Should the STAIR Criteria Be Modified for Preconditioning Studies?
- (2012) Michael M. Wang et al. Translational Stroke Research
- Mechanisms of Hydrocephalus After Neonatal and Adult Intraventricular Hemorrhage
- (2012) Jennifer Strahle et al. Translational Stroke Research
- RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research
- (2012) Paul A. Lapchak et al. Translational Stroke Research
- Post-Ischemic Inflammation in the Brain
- (2012) Takashi Shichita et al. Frontiers in Immunology
- Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia
- (2011) Waltraud Pfeilschifter et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme
- (2011) Nadia F. Lamour et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The immunology of stroke: from mechanisms to translation
- (2011) Costantino Iadecola et al. NATURE MEDICINE
- How to make better use of thrombolytic therapy in acute ischemic stroke
- (2011) Geoffrey A. Donnan et al. Nature Reviews Neurology
- FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia
- (2011) Arthur Liesz et al. PLoS One
- Sphingosine 1-phosphate in coagulation and inflammation
- (2011) Hideru Obinata et al. Seminars in Immunopathology
- Molecular Pathophysiology of Cerebral Hemorrhage
- (2011) Jaroslaw Aronowski et al. STROKE
- Sphingosine Kinase 2 Mediates Cerebral Preconditioning and Protects the Mouse Brain Against Ischemic Injury
- (2011) Lai Ming Yung et al. STROKE
- The Impact of Bioactive Lipids on Cardiovascular Development
- (2011) Alexander Kleger et al. Stem Cells International
- Fingolimod provides long-term protection in rodent models of cerebral ischemia
- (2010) Ying Wei et al. ANNALS OF NEUROLOGY
- Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis
- (2010) Athanasia Skoura et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Sphingosine kinase and sphingosine 1-phosphate in asthma
- (2010) Wen‑Qi Lai et al. BIOSCIENCE REPORTS
- S1P2, the G Protein-Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice
- (2010) W. Du et al. CANCER RESEARCH
- Sphingosylphosphorylcholine is a Proinflammatory Mediator in Cerebral Arteries
- (2010) Christiane Wirrig et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice
- (2010) Fei Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
- (2010) Kennedy R Lees et al. LANCET
- Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis
- (2010) Charlotte JJ van Asch et al. LANCET NEUROLOGY
- Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
- (2010) Sergio E. Alvarez et al. NATURE
- Fingolimod is a potential novel therapy for multiple sclerosis
- (2010) Orhan Aktas et al. Nature Reviews Neurology
- Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries
- (2010) Salvatore Salomone et al. PHARMACOLOGICAL RESEARCH
- Preclinical and clinical research on inflammation after intracerebral hemorrhage
- (2010) Jian Wang PROGRESS IN NEUROBIOLOGY
- Changing Face of Microglia
- (2010) M. B. Graeber SCIENCE
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- (2010) Yilin Zhou et al. STROKE
- Definition of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage as an Outcome Event in Clinical Trials and Observational Studies
- (2010) Mervyn D.I. Vergouwen et al. STROKE
- Clinical Translation of Cerebral Preconditioning
- (2010) Guohua Xi Translational Stroke Research
- The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia
- (2009) Bozena Czech et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species
- (2009) Noriko Takuwa et al. CARDIOVASCULAR RESEARCH
- Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: A possible role as a spasmogen
- (2009) Tetsu Kurokawa et al. JOURNAL OF CLINICAL NEUROSCIENCE
- T-bet–dependent S1P5expression in NK cells promotes egress from lymph nodes and bone marrow
- (2009) Craig N. Jenne et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
- (2009) Trung H.M. Pham et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation
- (2009) J. Michaud et al. JOURNAL OF IMMUNOLOGY
- Intracerebral haemorrhage
- (2009) Adnan I Qureshi et al. LANCET
- Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
- (2009) Arthur Liesz et al. NATURE MEDICINE
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
- (2009) N. C. Hait et al. SCIENCE
- Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance
- (2009) Bradley K. Wacker et al. STROKE
- Thrombin Inhibition by Argatroban Ameliorates Early Brain Injury and Improves Neurological Outcomes After Experimental Subarachnoid Hemorrhage in Rats
- (2009) Takashi Sugawara et al. STROKE
- Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats
- (2009) Yu Hasegawa et al. STROKE
- Molecular dissection of reactive astrogliosis and glial scar formation
- (2009) Michael V. Sofroniew TRENDS IN NEUROSCIENCES
- Inhibitory Effects of Eicosapentaenoic Acid on Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage: Possible Involvement of a Sphingosylphosphorylcholine-Rho-Kinase Pathway
- (2008) Satoshi Shirao et al. CEREBROVASCULAR DISEASES
- Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
- (2008) Krishnan Venkataraman et al. CIRCULATION RESEARCH
- Sphingosine-1-Phosphate in the Regulation of Vascular Tone
- (2008) Bodo Levkau CIRCULATION RESEARCH
- Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632
- (2008) Hyoung June Kim et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
- (2008) J.-S. BAE et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Stroke
- (2008) Geoffrey A Donnan et al. LANCET
- Principles of bioactive lipid signalling: lessons from sphingolipids
- (2008) Yusuf A. Hannun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- L-PDMP improves glucosylceramide synthesis and behavior in rats with focal ischemia
- (2008) Harumi Hisaki et al. NEUROLOGICAL RESEARCH
- Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
- (2008) Werner Hacke et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
- (2008) A. Kawahara et al. SCIENCE
- Antagonism of Sphingosine 1-Phosphate Receptor-2 Enhances Migration of Neural Progenitor Cells Toward an Area of Brain Infarction
- (2008) Atsushi Kimura et al. STROKE
- The multi-functional role of sphingosylphosphorylcholine
- (2007) Graeme F. Nixon et al. PROGRESS IN LIPID RESEARCH
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