标题
4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1
作者
关键词
mTORC1, structure, cryo-electron microscopy
出版物
Protein & Cell
Volume 7, Issue 12, Pages 878-887
出版商
Springer Nature
发表日期
2016-12-01
DOI
10.1007/s13238-016-0346-6
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tor forms a dimer through an N-terminal helical solenoid with a complex topology
- (2016) Domagoj Baretić et al. Nature Communications
- GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling
- (2015) C. Stretton et al. BIOCHEMICAL JOURNAL
- NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition
- (2015) Hai-Xin Yuan et al. GENES & DEVELOPMENT
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
- (2013) Xueming Li et al. NATURE METHODS
- High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
- (2013) Shaoxia Chen et al. ULTRAMICROSCOPY
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
- (2011) Elaine A. Dunlop et al. Autophagy
- mTOR signaling in disease
- (2011) Eva Dazert et al. CURRENT OPINION IN CELL BIOLOGY
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started