Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

(2016) Sang Ho Lee et al.   Science Translational Medicine

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

(2015) Maya A. Farha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GneZ, a UDP-GlcNAc 2-Epimerase, Is Required for S-Layer Assembly and Vegetative Growth of Bacillus anthracis

(2014) Y.-T. Wang et al.   JOURNAL OF BACTERIOLOGY

Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids

(2014) J. P. Santa Maria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wall Teichoic Acids of Gram-Positive Bacteria

(2013) Stephanie Brown et al.   Annual Review of Microbiology

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Auxiliary factors: a chink in the armor of MRSA resistance to β-lactam antibiotics

(2013) Terry Roemer et al.   CURRENT OPINION IN MICROBIOLOGY

Teichoic acid biosynthesis as an antibiotic target

(2013) Lincoln W Pasquina et al.   CURRENT OPINION IN MICROBIOLOGY

Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics

(2013) Edward WC Sewell et al.   JOURNAL OF ANTIBIOTICS

Staphylococcus aureus Mutants Lacking the LytR-CpsA-Psr Family of Enzymes Release Cell Wall Teichoic Acids into the Extracellular Medium

(2013) Y. G. Y. Chan et al.   JOURNAL OF BACTERIOLOGY

Use of a Bacteriophage Lysin to Identify a Novel Target for Antimicrobial Development

(2013) Raymond Schuch et al.   PLoS One

Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents

(2013) Yong Xu et al.   ACS Medicinal Chemistry Letters

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

Dual Roles of FmtA in Staphylococcus aureus Cell Wall Biosynthesis and Autolysis

(2012) Aneela Qamar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response

(2012) Vanina Dengler et al.   FEMS MICROBIOLOGY LETTERS

Wall teichoic acid protects Staphylococcus aureus from inhibition by Congo red and other dyes

(2012) T. Suzuki et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Recent developments and applications of saturation transfer difference nuclear magnetic resonance (STD NMR) spectroscopy

(2012) Jane L. Wagstaff et al.   Molecular BioSystems

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

(2012) S. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABC Transporters Required for Export of Wall Teichoic Acids Do Not Discriminate between Different Main Chain Polymers

(2011) Kathrin Schirner et al.   ACS Chemical Biology

Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

(2011) Sang Ho Lee et al.   CHEMISTRY & BIOLOGY

LytR-CpsA-Psr proteins in Staphylococcus aureus display partial functional redundancy and the deletion of all three severely impairs septum placement and cell separation

(2011) Benjamin Over et al.   FEMS MICROBIOLOGY LETTERS

Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses inStaphylococcus aureus

(2010) Jennifer Campbell et al.   ACS Chemical Biology

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

(2010) Kyungae Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of PknB Kinase in Antibiotic Resistance and Virulence in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strain USA300

(2010) S. Tamber et al.   INFECTION AND IMMUNITY

Antibiotic resistance of bacterial biofilms

(2010) Niels Høiby et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms

(2010) R. Singh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development

(2010) L. M. Holland et al.   MICROBIOLOGY-SGM

Role of staphylococcal wall teichoic acid in targeting the major autolysin Atl

(2010) Martin Schlag et al.   MOLECULAR MICROBIOLOGY

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus

(2010) M. L. Atilano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New  -Lactams That Meet the Challenge

(2009) L. I. Llarrull et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

(2009) Joann Huber et al.   CHEMISTRY & BIOLOGY

Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis

(2009) Kathrin Schirner et al.   EMBO JOURNAL

The wall teichoic acid and lipoteichoic acid polymers of Staphylococcus aureus

(2009) Guoqing Xia et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The N-Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus

(2009) M. A. D'Elia et al.   JOURNAL OF BACTERIOLOGY

Are essential genes really essential?

(2009) Michael A. D’Elia et al.   TRENDS IN MICROBIOLOGY

Staphylococcus aureus PBP4 Is Essential for  -Lactam Resistance in Community-Acquired Methicillin-Resistant Strains

(2008) G. Memmi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Revised Pathway Proposed for Staphylococcus aureus Wall Teichoic Acid Biosynthesis Based on In Vitro Reconstitution of the Intracellular Steps

(2008) Stephanie Brown et al.   CHEMISTRY & BIOLOGY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases

(2008) Lucas M Velloso et al.   EMBO REPORTS

Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases

(2008) M. P. Pereira et al.   JOURNAL OF BACTERIOLOGY

Late-Stage Polyribitol Phosphate Wall Teichoic Acid Biosynthesis in Staphylococcus aureus

(2008) T. C. Meredith et al.   JOURNAL OF BACTERIOLOGY

Wall teichoic acids are dispensable for anchoring the PNAG exopolysaccharide to the Staphylococcus aureus cell surface

(2008) M. Vergara-Irigaray et al.   MICROBIOLOGY-SGM

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

(2008) Christopher Weidenmaier et al.   NATURE REVIEWS MICROBIOLOGY