Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics

Is the GAIN Act a turning point in new antibiotic discovery?

(2013) Eric D. Brown   CANADIAN JOURNAL OF MICROBIOLOGY

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response

(2012) Vanina Dengler et al.   FEMS MICROBIOLOGY LETTERS

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

(2012) S. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to  -Lactam Antibiotics

(2012) C. M. Tan et al.   Science Translational Medicine

A widespread family of bacterial cell wall assembly proteins

(2011) Yoshikazu Kawai et al.   EMBO JOURNAL

Whole-Genome Sequencing of Staphylococcus aureus Strain RN4220, a Key Laboratory Strain Used in Virulence Research, Identifies Mutations That Affect Not Only Virulence Factors but Also the Fitness of the Strain

(2011) D. Nair et al.   JOURNAL OF BACTERIOLOGY

Studies of the Genetics, Function, and Kinetic Mechanism of TagE, the Wall Teichoic Acid Glycosyltransferase inBacillus subtilis168

(2011) Sarah E. Allison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

(2011) M. Spitzer et al.   Molecular Systems Biology

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

Antibiotics as probes of biological complexity

(2011) Shannon B Falconer et al.   Nature Chemical Biology

Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses inStaphylococcus aureus

(2010) Jennifer Campbell et al.   ACS Chemical Biology

Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus

(2010) Kyungae Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity

(2010) Maya A. Farha et al.   CHEMISTRY & BIOLOGY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Glycosylation of Wall Teichoic Acid inStaphylococcus aureusby TarM

(2010) Guoqing Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of staphylococcal wall teichoic acid in targeting the major autolysin Atl

(2010) Martin Schlag et al.   MOLECULAR MICROBIOLOGY

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus

(2010) M. L. Atilano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis inStaphylococcus aureus

(2009) Jonathan G. Swoboda et al.   ACS Chemical Biology

Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis

(2009) Michael A. D'Elia et al.   CHEMISTRY & BIOLOGY

Wall Teichoic Acid Protects Staphylococcus aureus against Antimicrobial Fatty Acids from Human Skin

(2009) T. Kohler et al.   JOURNAL OF BACTERIOLOGY

The N-Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus

(2009) M. A. D'Elia et al.   JOURNAL OF BACTERIOLOGY

The Wall Teichoic Acid Polymerase TagF Is Non-processivein Vitroand Amenable to Study Using Steady State Kinetic Analysis

(2009) Edward W. C. Sewell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureus PBP4 Is Essential for  -Lactam Resistance in Community-Acquired Methicillin-Resistant Strains

(2008) G. Memmi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III

(2008) Mark P. Pereira et al.   CHEMBIOCHEM

A Revised Pathway Proposed for Staphylococcus aureus Wall Teichoic Acid Biosynthesis Based on In Vitro Reconstitution of the Intracellular Steps

(2008) Stephanie Brown et al.   CHEMISTRY & BIOLOGY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Use of CDP-Glycerol as an Alternate Acceptor for the Teichoic Acid Polymerase Reveals that Membrane Association Regulates Polymer Length

(2008) J. W. Schertzer et al.   JOURNAL OF BACTERIOLOGY

Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases

(2008) M. P. Pereira et al.   JOURNAL OF BACTERIOLOGY

Late-Stage Polyribitol Phosphate Wall Teichoic Acid Biosynthesis in Staphylococcus aureus

(2008) T. C. Meredith et al.   JOURNAL OF BACTERIOLOGY

Wall teichoic acids are dispensable for anchoring the PNAG exopolysaccharide to the Staphylococcus aureus cell surface

(2008) M. Vergara-Irigaray et al.   MICROBIOLOGY-SGM

Membrane lipid homeostasis in bacteria

(2008) Yong-Mei Zhang et al.   NATURE REVIEWS MICROBIOLOGY

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

(2008) Christopher Weidenmaier et al.   NATURE REVIEWS MICROBIOLOGY