Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

High burden of copy number alterations andc-MYCamplification in prostate cancer fromBRCA2germline mutation carriers

(2015) E. Castro et al.   ANNALS OF ONCOLOGY

Molding BRCA2 function through its interacting partners

(2015) Juan S Martinez et al.   CELL CYCLE

FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex

(2015) Maya Raghunandan et al.   CELL CYCLE

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

(2015) Michal Kovac et al.   Nature Communications

Breast-Cancer Risk in Families with Mutations in PALB2

(2014) Antonis C. Antoniou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Animal Models in Osteosarcoma

(2014) Maria V. Guijarro et al.   Frontiers in Oncology

Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1-PALB2-BRCA2 Complex

(2013) M. Al Abo et al.   CANCER RESEARCH

Heterozygous mutations in thePALB2hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines

(2013) Landon Wark et al.   GENES CHROMOSOMES & CANCER

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

(2013) J-Y Park et al.   ONCOGENE

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

(2013) C. Bowman-Colin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterozygous mutations in PALB2 cause DNA replication and damage response defects

(2013) Jenni Nikkilä et al.   Nature Communications

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay

(2012) Kajal Biswas et al.   HUMAN MOLECULAR GENETICS

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

(2011) Tobias Menzel et al.   EMBO REPORTS

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

(2011) Peter Bouwman et al.   JOURNAL OF PATHOLOGY

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

(2011) Nicolas Siaud et al.   PLoS Genetics

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

(2010) Henne Holstege et al.   BMC CANCER

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

(2010) Pia Rantakari et al.   HUMAN MOLECULAR GENETICS

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

Structural basis for recruitment of BRCA2 by PALB2

(2009) Antony W Oliver et al.   EMBO REPORTS

Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2

(2008) Sergey G Kuznetsov et al.   NATURE MEDICINE