Genome-wide association studies and type 2 diabetes

Building Genetic Scores to Predict Risk of Complex Diseases in Humans: Is It Possible?

(2010) S. Liu et al.   DIABETES

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes

(2010) Z. Schroner et al.   DIABETES OBESITY & METABOLISM

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes

(2010) Lu Qi et al.   HUMAN MOLECULAR GENETICS

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

(2010) Rachel M Freathy et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

(2010) Toshimasa Yamauchi et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control

(2010) Scott B. Widenmaier et al.   PLoS One

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Functional Genomics Complements Quantitative Genetics in Identifying Disease-Gene Associations

(2010) Yuanfang Guan et al.   PLoS Computational Biology

Identification of New Genetic Risk Variants for Type 2 Diabetes

(2010) Xiao Ou Shu et al.   PLoS Genetics

A Novel Adaptive Method for the Analysis of Next-Generation Sequencing Data to Detect Complex Trait Associations with Rare Variants Due to Gene Main Effects and Interactions

(2010) Dajiang J. Liu et al.   PLoS Genetics

A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese

(2010) Fuu-Jen Tsai et al.   PLoS Genetics

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

Origins and functional impact of copy number variation in the human genome

(2009) Donald F. Conrad et al.   NATURE

New common variants affecting susceptibility to basal cell carcinoma

(2009) Simon N Stacey et al.   NATURE GENETICS

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

(2009) Johan Rung et al.   NATURE GENETICS

From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes

(2009) Zhi Wei et al.   PLoS Genetics

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

(2008) Bingshan Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population

(2008) M. Vaxillaire et al.   DIABETES

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

(2008) M. Orho-Melander et al.   DIABETES

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes

(2008) Martine Vaxillaire et al.   ENDOCRINE REVIEWS

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

(2008) Itsik Pe'er et al.   GENETIC EPIDEMIOLOGY

The Genetics of Type 2 Diabetes: A Realistic Appraisal in 2008

(2008) Jose C. Florez   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

(2008) Hiroyuki Unoki et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

The road to genome-wide association studies

(2008) Leonid Kruglyak   NATURE REVIEWS GENETICS

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels

(2008) N. Bouatia-Naji et al.   SCIENCE

Type 2 diabetes: new genes, new understanding

(2008) Inga Prokopenko et al.   TRENDS IN GENETICS