The Differential Response of Proteins to Macromolecular Crowding

Revisiting a dogma: the effect of volume exclusion in molecular crowding

(2015) Anastasia Politou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

NMR studies of protein folding and binding in cells and cell-like environments

(2015) Austin E Smith et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quinary structure modulates protein stability in cells

(2015) William B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimal Effects of Macromolecular Crowding on an Intrinsically Disordered Protein: A Small-Angle Neutron Scattering Study

(2014) David P. Goldenberg et al.   BIOPHYSICAL JOURNAL

Protein Stabilization by Macromolecular Crowding through Enthalpy Rather Than Entropy

(2014) Michael Senske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Residue level quantification of protein stability in living cells

(2014) W. B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments

(2014) Andrea Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Folded Excited State of Ligand-Free Nuclear Coactivator Binding Domain (NCBD) Underlies Plasticity in Ligand Recognition

(2013) Magnus Kjaergaard et al.   BIOCHEMISTRY

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Single-molecule spectroscopy of protein folding dynamics—expanding scope and timescales

(2013) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Dynamics Simulations of Highly Crowded Amino Acid Solutions: Comparisons of Eight Different Force Field Combinations with Experiment and with Each Other

(2013) Casey T. Andrews et al.   Journal of Chemical Theory and Computation

Molecular Crowding Stabilizes Both the Intrinsically Disordered Calcium-Free State and the Folded Calcium-Bound State of a Repeat in Toxin (RTX) Protein

(2013) Ana-Cristina Sotomayor-Pérez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reduced Native State Stability in Crowded Cellular Environment Due to Protein–Protein Interactions

(2013) Ryuhei Harada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of the Intrinsic Helix Propensity of an Intrinsically Disordered Protein Reveals Long-Range Helix–Helix Interactions

(2013) Vytautas Iešmantavičius et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells

(2013) Christopher A. Waudby et al.   PLoS One

Denatured State Structural Property Determines Protein Stabilization by Macromolecular Crowding: A Thermodynamic and Structural Approach

(2013) Shruti Mittal et al.   PLoS One

Impact of reconstituted cytosol on protein stability

(2013) M. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A decade and a half of protein intrinsic disorder: Biology still waits for physics

(2013) Vladimir N. Uversky   PROTEIN SCIENCE

MDWeb and MDMoby: an integrated web-based platform for molecular dynamics simulations

(2012) Adam Hospital et al.   BIOINFORMATICS

Is a Malleable Protein Necessarily Highly Dynamic? The Hydrophobic Core of the Nuclear Coactivator Binding Domain Is Well Ordered

(2012) Magnus Kjaergaard et al.   BIOPHYSICAL JOURNAL

Conformational Sampling of Peptides in the Presence of Protein Crowders from AA/CG-Multiscale Simulations

(2012) Alexander V. Predeus et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Macromolecular Crowding and Protein Stability

(2012) Yaqiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Crowding Affects Hydration Structure and Dynamics

(2012) Ryuhei Harada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multimolecule test-tube simulations of protein unfolding and aggregation

(2012) M. E. McCully et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Preformed Binding Interface in the Unbound Ensemble of an Intrinsically Disordered Protein: Evidence from Molecular Simulations

(2012) Michael Knott et al.   PLoS Computational Biology

Protein Disorder Prevails under Crowded Conditions

(2011) Cs. Szasz et al.   BIOCHEMISTRY

Effects of Macromolecular Crowding on an Intrinsically Disordered Protein Characterized by Small-Angle Neutron Scattering with Contrast Matching

(2011) Daniel Johansen et al.   BIOPHYSICAL JOURNAL

Variable Interactions between Protein Crowders and Biomolecular Solutes Are Important in Understanding Cellular Crowding

(2011) Michael Feig et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Native Ensemble and Folding of a Protein Molten-Globule: Functional Consequence of Downhill Folding

(2011) Athi N. Naganathan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Models of macromolecular crowding effects and the need for quantitative comparisons with experiment

(2010) Adrian H Elcock   CURRENT OPINION IN STRUCTURAL BIOLOGY

Effects of Proteins on Protein Diffusion

(2010) Yaqiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macromolecular Crowding Remodels the Energy Landscape of a Protein by Favoring a More Compact Unfolded State

(2010) Jiang Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

(2010) Magnus Kjaergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature-dependent structural changes in intrinsically disordered proteins: Formation of α-helices or loss of polyproline II?

(2010) Magnus Kjaergaard et al.   PROTEIN SCIENCE

Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm

(2010) Sean R. McGuffee et al.   PLoS Computational Biology

Post-reductionist protein science, or putting Humpty Dumpty back together again

(2009) Lila M Gierasch et al.   Nature Chemical Biology

Nonadditive effects of mixed crowding on protein stability

(2009) Jyotica Batra et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Crowding Effects on Diffusion in Solutions and Cells

(2008) James A. Dix et al.   Annual Review of Biophysics

Modeling of Aqueous Poly(oxyethylene) Solutions:  1. Atomistic Simulations

(2008) Jan Fischer et al.   JOURNAL OF PHYSICAL CHEMISTRY B