Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission

A Randomized, Placebo-Controlled, Active-Reference, Double-Blind, Flexible-Dose Study of the Efficacy of Vortioxetine on Cognitive Function in Major Depressive Disorder

(2015) Atul R Mahableshwarkar et al.   NEUROPSYCHOPHARMACOLOGY

Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data

(2015) Connie Sanchez et al.   PHARMACOLOGY & THERAPEUTICS

Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain

(2015) Mostafa El Mansari et al.   PSYCHOPHARMACOLOGY

Existence and Control of Go/No-Go Decision Transition Threshold in the Striatum

(2015) Jyotika Bahuguna et al.   PLoS Computational Biology

Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - a quantitative EEG study in rats

(2014) S C Leiser et al.   BRITISH JOURNAL OF PHARMACOLOGY

P.2.a.016 Reversal by vortioxetine of age-induced memory impairment is associated with changes in specific gene expressions in female mice

(2014) Y. Li et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

(2014) Ashley Wallace et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults

(2014) Roger S. McIntyre et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus

(2014) Elena Dale et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus

(2014) Krzysztof Tokarski et al.   Pharmacological Reports

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

(2013) Alan L. Pehrson et al.   CNS SPECTRUMS

Untangling GABAergic wiring in the cortical microcircuit

(2013) Yoshiyuki Kubota   CURRENT OPINION IN NEUROBIOLOGY

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS

(2013) Roger S. McIntyre et al.   DEPRESSION AND ANXIETY

P.2.e.003 Role of 5-HT3 receptors in the mechanism of action of the investigational antidepressant vortioxetine

(2013) M.S. Riga et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

(2013) Kristian Gaarn du Jardin et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation

(2013) Jesper Bornø Jensen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A proposal for an updated neuropsychopharmacological nomenclature

(2013) Joseph Zohar et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Lesions of the dorsomedial striatum impair formation of attentional set in rats

(2013) Hanna S. Lindgren et al.   NEUROPHARMACOLOGY

Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

(2013) Arne Mørk et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder

(2012) Cornelius Katona et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

The Native Serotonin 5-HT5A Receptor: Electrophysiological Characterization in Rodent Cortex and 5-HT1A-Mediated Compensatory Plasticity in the Knock-Out Mouse

(2012) N. M. Goodfellow et al.   JOURNAL OF NEUROSCIENCE

Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones

(2012) Ruixi Luo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task

(2012) Clara S Humpston et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Distribution of Serotonin Receptor of Type 6 (5-HT6) in Human Brain Post-mortem. A Pharmacology, Autoradiography and Immunohistochemistry Study

(2012) Donatella Marazziti et al.   NEUROCHEMICAL RESEARCH

Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: An immunohistochemical and immunofluorescence study

(2012) Donatella Marazziti et al.   NEUROCHEMISTRY INTERNATIONAL

5-HT1A Receptor Agonists Enhance Pyramidal Cell Firing in Prefrontal Cortex Through a Preferential Action on GABA Interneurons

(2011) L. Llado-Pelfort et al.   CEREBRAL CORTEX

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

(2011) Benny Bang-Andersen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serotonin and Prefrontal Cortex Function: Neurons, Networks, and Circuits

(2011) M. Victoria Puig et al.   MOLECULAR NEUROBIOLOGY

Co-expression of serotonin 5-HT1B and 5-HT4 receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum

(2011) Martin Egeland et al.   NEUROPHARMACOLOGY

Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum

(2011) J.A. Goldberg et al.   NEUROSCIENCE

Differential Regulation of the Excitability of Prefrontal Cortical Fast-Spiking Interneurons and Pyramidal Neurons by Serotonin and Fluoxetine

(2011) Ping Zhong et al.   PLoS One

Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats

(2011) Petra J. J. Baarendse et al.   PSYCHOPHARMACOLOGY

Serotonin Modulates Fast-Spiking Interneuron and Synchronous Activity in the Rat Prefrontal Cortex through 5-HT1A and 5-HT2A Receptors

(2010) M. V. Puig et al.   JOURNAL OF NEUROSCIENCE

Lateral competition for cortical space by layer-specific horizontal circuits

(2010) Hillel Adesnik et al.   NATURE

A subpopulation of serotonin1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus

(2010) C.J. Peddie et al.   NEUROSCIENCE LETTERS

Serotonin excites fast-spiking interneurons in the striatum

(2009) Craig P. Blomeley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anterior Cingulate Neurons Represent Errors and Preparatory Attention within the Same Behavioral Sequence

(2009) N. K. B. Totah et al.   JOURNAL OF NEUROSCIENCE

Dendritic colocalisation of serotonin1B receptors and the glutamate NMDA receptor subunit NR1 within the hippocampal dentate gyrus: An ultrastructural study

(2008) C.J. Peddie et al.   JOURNAL OF CHEMICAL NEUROANATOMY