Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain

A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults

(2014) Roger S. McIntyre et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

(2013) Alan L. Pehrson et al.   CNS SPECTRUMS

5-HTT and 5-HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects

(2013) Per Stenkrona et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

(2013) L. Citrome   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

(2013) Jean-Philippe Guilloux et al.   NEUROPHARMACOLOGY

Serotonin and beyond: therapeutics for major depression

(2013) P. Blier et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prenatal exposure to escitalopram and/or stress in rats

(2013) Chase H. Bourke et al.   PSYCHOPHARMACOLOGY

Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters—A rat microdialysis and electrophysiology study

(2012) Alan L. Pehrson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder

(2012) Cornelius Katona et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

(2012) Cécile Bétry et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Occupancy of the Serotonin Transporter after Administration of Lu AA21004 and its Relation to Plasma Concentration in Healthy Subjects

(2011) Johan Areberg et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

(2011) Benny Bang-Andersen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy

(2011) Ouissame Mnie-Filali et al.   NEUROPSYCHOPHARMACOLOGY