Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus

Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data

(2015) Connie Sanchez et al.   PHARMACOLOGY & THERAPEUTICS

Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - a quantitative EEG study in rats

(2014) S C Leiser et al.   BRITISH JOURNAL OF PHARMACOLOGY

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

(2013) Alan L. Pehrson et al.   CNS SPECTRUMS

Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

(2013) Kristian Gaarn du Jardin et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation

(2013) Jesper Bornø Jensen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression

(2013) Philip Cowen et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

(2013) Arne Mørk et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder

(2012) Cornelius Katona et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: Mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone

(2011) Tomoko Horisawa et al.   BEHAVIOURAL BRAIN RESEARCH

A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder

(2011) Enric Alvarez et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Residual Symptoms in Depressed Outpatients Who Respond by 50% But Do Not Remit to Antidepressant Medication

(2011) Shawn M. McClintock et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

(2011) Benny Bang-Andersen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Role of 5-Hydroxytryptamine 7 Receptors in the Phencyclidine-Induced Novel Object Recognition Deficit in Rats

(2011) M. Horiguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration

(2010) Sophie Parmentier-Batteur et al.   NEUROPHARMACOLOGY

Presence of individual (residual) symptoms during depressive episodes and periods of remission: a 3-year prospective study

(2010) H. J. Conradi et al.   PSYCHOLOGICAL MEDICINE

Activation of the 5-HT6 receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus

(2009) P.J. West et al.   NEUROSCIENCE

Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat

(2009) Samantha L. McLean et al.   PSYCHOPHARMACOLOGY

Coupling of Theta Oscillations between Anterior and Posterior Midline Cortex and with the Hippocampus in Freely Behaving Rats

(2008) C. K. Young et al.   CEREBRAL CORTEX

Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels

(2008) Pan-Yue Deng et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

5-HT excites globus pallidus neurons by multiple receptor mechanisms

(2007) L. Chen et al.   NEUROSCIENCE