Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation

(2015) Juan Fontana et al.   JOURNAL OF VIROLOGY

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

(2014) Craig Fenwick et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Allosteric Inhibition of Human Immunodeficiency Virus Integrase

(2014) Kushol Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

(2014) Nikoloz Shkriabai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

(2014) Alison Slaughter et al.   Retrovirology

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

(2014) Lee D. Fader et al.   ACS Medicinal Chemistry Letters

A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

(2014) Amit Sharma et al.   PLoS Pathogens

Deformable elastic network refinement for low-resolution macromolecular crystallography

(2014) Gunnar F. Schröder et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

(2013) Lei Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells

(2013) Mini Balakrishnan et al.   PLoS One

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

(2013) K. A. Jurado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

(2013) Erwann Le Rouzic et al.   Retrovirology

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

HIV DNA Integration

(2013) R. Craigie et al.   Cold Spring Harbor Perspectives in Medicine

Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase fromCorynebacterium glutamicum

(2012) Axel T. Brunger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

(2012) Frauke Christ et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

(2012) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural biology of HIV-1: mechanistic and therapeutic insights

(2012) Alan Engelman et al.   NATURE REVIEWS MICROBIOLOGY

Improving the Accuracy of Macromolecular Structure Refinement at 7 Å Resolution

(2012) Axel T. Brunger et al.   STRUCTURE

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy

(2012) Frauke Christ et al.   VIROLOGY

HIV integrase as a target for antiretroviral therapy

(2012) Daria J. Hazuda   Current Opinion in HIV and AIDS

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Properties of HIV Integrase·Lens Epithelium-derived Growth Factor Oligomers

(2010) Kushol Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

Augmentation of Reverse Transcription by Integrase through an Interaction with Host Factor, SIP1/Gemin2 Is Critical for HIV-1 Infection

(2009) Hironori Nishitsuji et al.   PLoS One

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs

(2009) A. Alian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Structural Basis for Functional Tetramerization of Lentiviral Integrase

(2009) Stephen Hare et al.   PLoS Pathogens

Taxol Allosterically Alters the Dynamics of the Tubulin Dimer and Increases the Flexibility of Microtubules

(2008) Arpita Mitra et al.   BIOPHYSICAL JOURNAL