The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation

(2015) Jenny H. Hong et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1

(2014) Su Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Measuring genetic interactions in human cells by RNAi and imaging

(2014) Christina Laufer et al.   Nature Protocols

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

(2014) Dariel Ashton-Beaucage et al.   PLOS BIOLOGY

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

(2013) Heon-Ki Kim et al.   CELL

USP47 and C Terminus of Hsp70-Interacting Protein (CHIP) Antagonistically Regulate Katanin-p60-Mediated Axonal Growth

(2013) S. W. Yang et al.   JOURNAL OF NEUROSCIENCE

Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy

(2013) Dominik M. Haddad et al.   MOLECULAR CELL

Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome

(2013) Stefanie Duttler et al.   MOLECULAR CELL

UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy

(2013) T. Tasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tay Bridge Is a Negative Regulator of EGFR Signalling and Interacts with Erk and Mkp3 in the Drosophila melanogaster Wing

(2013) Cristina Molnar et al.   PLoS Genetics

Non-canonical ubiquitin-based signals for proteasomal degradation

(2012) Y. Kravtsova-Ivantsiv et al.   JOURNAL OF CELL SCIENCE

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47

(2012) Joseph Weinstock et al.   ACS Medicinal Chemistry Letters

The Spalt transcription factors regulate cell proliferation, survival and epithelial integrity downstream of the Decapentaplegic signalling pathway

(2012) M. F. Organista et al.   Biology Open

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi

(2011) Elin Axelsson et al.   BMC BIOINFORMATICS

USP47 Is a Deubiquitylating Enzyme that Regulates Base Excision Repair by Controlling Steady-State Levels of DNA Polymerase β

(2011) Jason L. Parsons et al.   MOLECULAR CELL

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

(2011) Thomas Horn et al.   NATURE METHODS

Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal-Regulated Kinase Signaling

(2011) A. A. Friedman et al.   Science Signaling

The Exon Junction Complex Controls the Splicing of mapk and Other Long Intron-Containing Transcripts in Drosophila

(2010) Dariel Ashton-Beaucage et al.   CELL

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

The ubiquitin-specific protease USP47 is a novel β-TRCP interactor regulating cell survival

(2009) A Peschiaroli et al.   ONCOGENE

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

(2009) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate selection by the proteasome during degradation of protein complexes

(2008) Sumit Prakash et al.   Nature Chemical Biology

Defining genetic interaction

(2008) R. Mani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extent of N-terminal modifications in cytosolic proteins from eukaryotes

(2008) Aude Martinez et al.   PROTEOMICS