Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

(2015) A. Kumar et al.   EMBO JOURNAL

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

(2015) A. Kazlauskaite et al.   EMBO REPORTS

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Genetic Insights into Sporadic Parkinson's Disease Pathogenesis

(2014) Chou Chai et al.   CURRENT GENOMICS

PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation

(2014) Boram Min et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease

(2013) J. Weetman et al.   NEUROSCIENCE LETTERS

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Regulation of parkin and PINK1 by neddylation

(2012) Y. S. Choo et al.   HUMAN MOLECULAR GENETICS

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

(2012) Ji Won Um et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation

(2011) Yohan Oh et al.   BRAIN RESEARCH

Posttranslational Modifications as Versatile Regulators of Parkin Function

(2011) E. Rubio de la Torre et al.   CURRENT MEDICINAL CHEMISTRY

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

(2011) Yong Man Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

Interferon-Stimulated Gene 15 and the Protein ISGylation System

(2010) Dongxian Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Membrane Lipid Modification by Docosahexaenoic Acid (DHA) Promotes the Formation of α-Synuclein Inclusion Bodies Immunopositive for SUMO-1 in Oligodendroglial Cells After Oxidative Stress

(2010) Michael Riedel et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway

(2009) Young Joo Jeon et al.   EMBO REPORTS

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

(2009) Ventzislava A. Hristova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE