Antigenic variability: Obstacles on the road to vaccines against traditionally difficult targets

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus

(2016) Karuppiah Muthumani et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial

(2016) Johan F Vansteenkiste et al.   LANCET ONCOLOGY

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis

(2016) Rachael Natrajan et al.   PLOS MEDICINE

T cell responses in hepatitis C virus infection: Historical overview and goals for future research

(2015) Lauren Holz et al.   ANTIVIRAL RESEARCH

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

(2015) Pia Dosenovic et al.   CELL

Cancer Neoantigens and Applications for Immunotherapy

(2015) A. Desrichard et al.   CLINICAL CANCER RESEARCH

The role of active vaccination in cancer immunotherapy: lessons from clinical trials

(2015) Haydn T Kissick et al.   CURRENT OPINION IN IMMUNOLOGY

New approaches to HIV vaccine development

(2015) Barton F Haynes   CURRENT OPINION IN IMMUNOLOGY

Ubiquitous Autofragmentation of Fluorescent Proteins Creates Abundant Defective Ribosomal Products (DRiPs) for Immunosurveillance

(2015) Jiajie Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor neoantigens: building a framework for personalized cancer immunotherapy

(2015) Matthew M. Gubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapy: An immune one–two punch

(2015) Katherine Bourzac   NATURE

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

(2015) Jinal N Bhiman et al.   NATURE MEDICINE

Dengue vaccine: hypotheses to understand CYD-TDV-induced protection

(2015) Bruno Guy et al.   NATURE REVIEWS MICROBIOLOGY

Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease

(2015) Sri Rezeki Hadinegoro et al.   NEW ENGLAND JOURNAL OF MEDICINE

The modern era of HIV-1 vaccine development

(2015) J. R. Mascola   SCIENCE

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Immune Checkpoint Inhibitors in Melanoma Provide the Cornerstones for Curative Therapies

(2015) Alexander M.M. Eggermont et al.   SEMINARS IN ONCOLOGY

HIV-1 adaptation to HLA: a window into virus–host immune interactions

(2015) Jonathan M. Carlson et al.   TRENDS IN MICROBIOLOGY

Evaluation of non-reciprocal heterologous immunity between unrelated viruses

(2015) Jenny W. Che et al.   VIROLOGY

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

(2015) Brendon Y. Chua et al.   mBio

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus

(2015) Louis M. Schwartzman et al.   mBio

How Does Multistep Tumorigenesis Really Proceed?

(2015) Christine L. Chaffer et al.   Cancer Discovery

CD8 T Cell Response Maturation Defined by Anentropic Specificity and Repertoire Depth Correlates with SIVΔnef-induced Protection

(2015) Sama Adnan et al.   PLoS Pathogens

A New Scientific Paradigm may be Needed to Finally Develop an HIV Vaccine

(2015) José Esparza   Frontiers in Immunology

Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy

(2015) Jashodeep Datta et al.   Frontiers in Immunology

Immunotherapy in Cancer: A Combat between Tumors and the Immune System; You Win Some, You Lose Some

(2015) Florencia Paula Madorsky Rowdo et al.   Frontiers in Immunology

Trial Watch: Peptide-based anticancer vaccines

(2015) Jonathan Pol et al.   OncoImmunology

Prior Population Immunity Reduces the Expected Impact of CTL-Inducing Vaccines for Pandemic Influenza Control

(2015) Kirsty J. Bolton et al.   PLoS One

Somatically mutated tumor antigens in the quest for a more efficacious patient-oriented immunotherapy of cancer

(2014) Zlatko Trajanoski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Responses to HCV and Other Hepatitis Viruses

(2014) Su-Hyung Park et al.   IMMUNITY

Induction of Broad Cross-Subtype-Specific HIV-1 Immune Responses by a Novel Multivalent HIV-1 Peptide Vaccine in Cynomolgus Macaques

(2014) A. Azizi et al.   JOURNAL OF IMMUNOLOGY

An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant

(2014) Usha K. Nivarthi et al.   JOURNAL OF IMMUNOLOGY

Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2–Restricted T Cell Epitopes

(2014) Rieuwert Hoppes et al.   JOURNAL OF IMMUNOLOGY

A Multivalent Clade C HIV-1 Env Trimer Cocktail Elicits a Higher Magnitude of Neutralizing Antibodies than Any Individual Component

(2014) Christine A. Bricault et al.   JOURNAL OF VIROLOGY

Impact of Sequence Variation in a Dominant HLA-A*02-Restricted Epitope in Hepatitis C Virus on Priming and Cross-Reactivity of CD8+ T Cells

(2014) S. Ziegler et al.   JOURNAL OF VIROLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Vaccines, new opportunities for a new society

(2014) R. Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nature and extent of contributions by defective ribosome products to the HLA peptidome

(2014) D. Bourdetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

(2014) S. Quinones-Parra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody landscapes after influenza virus infection or vaccination

(2014) J. M. Fonville et al.   SCIENCE

Xenogeneic therapeutic cancer vaccines as breakers of immune tolerance for clinical application: To use or not to use?

(2014) Marius M. Strioga et al.   VACCINE

Variable epitope library carrying heavily mutated survivin-derived CTL epitope variants as a new class of efficient vaccine immunogen tested in a mouse model of breast cancer

(2014) Allan NoeDominguez-Romero et al.   Human Vaccines & Immunotherapeutics

More Surprises in the Development of an HIV Vaccine

(2014) José Esparza et al.   Frontiers in Immunology

Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides

(2014) Ellis L. Reinherz et al.   Frontiers in Immunology

An Outdated Notion of Antibody Specificity is One of the Major Detrimental Assumptions of the Structure-Based Reverse Vaccinology Paradigm, Which Prevented It from Helping to Develop an Effective HIV-1 Vaccine

(2014) Marc H. V. Van Regenmortel   Frontiers in Immunology

T-Cell Immunity to Infection with Dengue Virus in Humans

(2014) Daniela Weiskopf et al.   Frontiers in Immunology

High sensitivity of cancer exome-based CD8 T cell neo-antigen identification

(2014) Marit M van Buuren et al.   OncoImmunology

T-Cell Immunity to Influenza A Viruses

(2013) Emma J. Grant et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Structural Vaccinology: A Three-dimensional View for Vaccine Development

(2013) Ilaria Ferlenghi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Vaccines based on structure-based design provide protection against infectious diseases

(2013) Sunil Thomas et al.   Expert Review of Vaccines

Improving Antigenic Peptide Vaccines for Cancer Immunotherapy Using a Dominant Tumor-specific T Cell Receptor

(2013) Jonathan D. Buhrman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

To dream the impossible dream: universal influenza vaccination

(2013) Jonathan W Yewdell   Current Opinion in Virology

Advances in structure-based vaccine design

(2013) Daniel W Kulp et al.   Current Opinion in Virology

On HIV diversity

(2012) Thumbi Ndung’u et al.   AIDS

The cancer antigenome

(2012) Bianca Heemskerk et al.   EMBO JOURNAL

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA

(2012) Jean-Philippe Julien et al.   IMMUNOLOGICAL REVIEWS

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

(2012) Julia Ekeruche-Makinde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies to alleviate original antigenic sin responses to influenza viruses

(2012) J. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic vaccines

(2012) James L. Gulley   Human Vaccines & Immunotherapeutics

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variable epitope libraries: New vaccine immunogens capable of inducing broad human immunodeficiency virus type 1-neutralizing antibody response

(2011) Claudia Charles-Niño et al.   VACCINE

Reverse Vaccinology: Developing Vaccines in the Era of Genomics

(2010) Alessandro Sette et al.   IMMUNITY

Conditional Superagonist CTL Ligands for the Promotion of Tumor-Specific CTL Responses

(2010) C. S. Abdul-Alim et al.   JOURNAL OF IMMUNOLOGY

Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens

(2010) K. R. Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Can Vaccines Against Influenza and Other Viral Diseases Be Made More Effective?

(2010) Peter L. Nara et al.   PLOS BIOLOGY

Variable epitope library-based vaccines: Shooting moving targets

(2009) Cesar Pedroza-Roldan et al.   MOLECULAR IMMUNOLOGY

Adaptation of HIV-1 to human leukocyte antigen class I

(2009) Yuka Kawashima et al.   NATURE

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Deceptive imprinting and immune refocusing in vaccine design

(2008) Gregory J. Tobin et al.   VACCINE

AIDSVAX immunization induces HIV-specific CD8+ T-cell responses in high-risk, HIV-negative volunteers who subsequently acquire HIV infection

(2008) Norman G. Jones et al.   VACCINE

Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity

(2008) Ralph Pantophlet et al.   VIROLOGY

Focusing the immune response on the V3 loop, a neutralizing epitope of the HIV-1 gp120 envelope

(2007) Susan Zolla-Pazner et al.   VIROLOGY