Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyondβ-Amyloid: Insights from Clinical Trials

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

(2018) Teodoro del Ser et al.   JOURNAL OF ALZHEIMERS DISEASE

Cell Signaling Pathways and Iron Chelation in the Neurorestorative Activity of Green Tea Polyphenols: Special Reference to Epigallocatechin Gallate (EGCG)

(2017) Silvia A. Mandel et al.   JOURNAL OF ALZHEIMERS DISEASE

Why Did Tarenflurbil Fail in Alzheimer's Disease?

(2017) Bruno P. Imbimbo   JOURNAL OF ALZHEIMERS DISEASE

The Quest for Small Molecules as Amyloid Inhibiting Therapies for Alzheimer's Disease

(2017) Hozefa Amijee et al.   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin Levels are Decreased in the Cerebrospinal Fluid of Women with Prodomal Alzheimer's Disease

(2017) Francisco J. Gil-Bea et al.   JOURNAL OF ALZHEIMERS DISEASE

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

(2013) Sandra Sivilia et al.   BMC NEUROSCIENCE

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Nous Sommes Tous des Bacteries: Implications for medicine, pharmacology and public health

(2012) David J. Triggle   BIOCHEMICAL PHARMACOLOGY

BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

(2012) Christina J. Crump et al.   BIOCHEMISTRY

EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study

(2012) B. Vellas et al.   Current Alzheimer Research

Alzheimer's Disease: Presenilin 2-Sparing  -Secretase Inhibition Is a Tolerable A  Peptide-Lowering Strategy

(2012) T. Borgegard et al.   JOURNAL OF NEUROSCIENCE

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

(2012) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

(2012) Giorgio Poli et al.   Prion

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

(2011) Sónia C. Correia et al.   AGEING RESEARCH REVIEWS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

CHOLINESTERASES, A TARGET OF PHARMACOLOGY AND TOXICOLOGY

(2011) Miroslav Pohanka   BIOMEDICAL PAPERS-OLOMOUC

Systemic and Central Immunity in Alzheimer's Disease: Therapeutic Implications

(2011) Joseph Butchart et al.   CNS Neuroscience & Therapeutics

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

(2011) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

(2011) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Suppresses the Expression of Amyloid Precursor Protein, Presenilins, and Glycogen Synthase Kinase-3β in Peripheral Blood Mononuclear Cells

(2011) Paresh Dandona et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease

(2011) S. Salloway et al.   NEUROLOGY

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

(2011) Laura A. Craig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older

(2011) Gerbrand J. Izaks et al.   PLoS One

Testing the Right Target and Right Drug at the Right Stage

(2011) R. A. Sperling et al.   Science Translational Medicine

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project

(2010) A. Wimo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

(2010) K N Manolopoulos et al.   MOLECULAR PSYCHIATRY

Beneficial network effects of methylene blue in an amnestic model

(2010) Penny D. Riha et al.   NEUROIMAGE

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Results of the first-in-man study with the active Aβ Immunotherapy CAD106 in Alzheimer patients

(2009) Bengt G. Winblad et al.   Alzheimers & Dementia

NIC5-15 as a treatment for Alzheimer's: Safety, pharmacokinetics and clinical variables

(2009) Hillel Grossman et al.   Alzheimers & Dementia

A safety, tolerability and pharmacokinetic study of dimebon in patients with Alzheimer's disease already receiving donepezil

(2009) Pierre Tariot et al.   Alzheimers & Dementia

Rember: Issues in design of a phase 3 disease modifying clinical trial of Tau aggregation inhibitor therapy in Alzheimer's disease

(2009) Claude Wischik   Alzheimers & Dementia

Beta-secretase as target for amyloid-reduction therapy

(2009) Jordan J.N. Tang   Alzheimers & Dementia

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

(2009) Randall J. Bateman et al.   ANNALS OF NEUROLOGY

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Cerebrospinal fluid β-amyloid and dynabridging in Alzheimer’s disease drug development

(2009) Larry Ereshefsky et al.   Biomarkers in Medicine

Piperidine-derived γ-secretase modulators

(2009) Adrian Hall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immunosenescence: what does it mean to health outcomes in older adults?

(2009) Janet E McElhaney et al.   CURRENT OPINION IN IMMUNOLOGY

Recent progress in the drug discovery of non-peptidic BACE1 inhibitors

(2009) Yoshio Hamada et al.   Expert Opinion on Drug Discovery

Development of semagacestat (LY450139), a functional γ-secretase inhibitor, for the treatment of Alzheimer's disease

(2009) David B Henley et al.   EXPERT OPINION ON PHARMACOTHERAPY

Secretase inhibitors and modulators for Alzheimer’s disease treatment

(2009) Taisuke Tomita   Expert Review of Neurotherapeutics

Metabolic links between diabetes and Alzheimer’s disease

(2009) Pamela A Maher et al.   Expert Review of Neurotherapeutics

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Can Lithium or Valproate Untie Tangles in Alzheimer's Disease?

(2009) Pierre N. Tariot et al.   JOURNAL OF CLINICAL PSYCHIATRY

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Tau oligomers and aggregation in Alzheimer’s disease

(2009) Marco A. Meraz-Ríos et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Reduction by Amyloid-  Vaccination Also Reduces Mouse Tau Pathology and Protects from Neuron Loss in Two Mouse Models of Alzheimer's Disease

(2009) D. M. Wilcock et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Development of microglia in the chick embryo spinal cord: Implications in the regulation of motoneuronal survival and death

(2009) Jordi Calderó et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Development of AFFITOPE vaccines for Alzheimer’s disease (AD) — From concept to clinical testing

(2009) A. Schneeberger et al.   Journal of Nutrition Health & Aging

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein  -Secretase for the Treatment of Alzheimer's Disease

(2009) R. L. Martone et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect

(2009) Richard J. Caselli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

The Atorvastatin/Donepezil in Alzheimer’s Disease Study (LEADe): Design and baseline characteristics

(2008) Roy W. Jones et al.   Alzheimers & Dementia

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

Memapsin 2 (Beta-Secretase) Inhibitors: Drug Development

(2008) Arun Ghosh et al.   Current Alzheimer Research

Neurofibrillary degeneration in Alzheimerʼs disease: from molecular mechanisms to identification of drug targets

(2008) Jin-Jing Pei et al.   CURRENT OPINION IN PSYCHIATRY

Therapeutic Potential of γ -Secretase Inhibitors and Modulators

(2008) Bruno Imbimbo   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease

(2008) Yi Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Emerging and potential therapies for Alzheimer's disease

(2008) Heledd H Griffiths et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Current and future therapy in Alzheimer’s disease

(2008) Robert J. van Marum   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Etazolate, a neuroprotective drug linking GABAAreceptor pharmacology to amyloid precursor protein processing

(2008) Maryline Marcade et al.   JOURNAL OF NEUROCHEMISTRY

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

(2008) Gordon K Wilcock et al.   LANCET NEUROLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease

(2008) Gary Landreth et al.   Neurotherapeutics

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

(2008) Serena Deiana et al.   PSYCHOPHARMACOLOGY

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease

(2007) Dione Kobayashi et al.   NEUROBIOLOGY OF AGING

Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages

(2007) Amitabha Majumdar et al.   NEUROBIOLOGY OF AGING