Article
Pharmacology & Pharmacy
Chang Huang, Tozammel Hoque, Reina Bendayan
Summary: The implementation of combined antiretroviral therapy (cART) significantly reduces HIV-associated mortality. However, complications such as HIV-associated neurocognitive disorders (HAND) remain a major concern. This study found that antiretroviral drugs (ARVs) may contribute to the pathogenesis of HAND by affecting blood-brain barrier integrity and permeability. Specifically, certain ARVs were found to downregulate tight junction proteins, upregulate proinflammatory cytokines, and alter membrane-associated transporters, leading to increased BBB permeability. These findings suggest a potential link between ARVs and cerebrovascular pathology in HIV patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Si-yi Xu, Hui-jie Bian, Shu Shu, Sheng-nan Xia, Yue Gu, Mei-juan Zhang, Yun Xu, Xiang Cao
Summary: Inhibiting AIM2 appears to preserve BBB integrity after ischemic stroke by modulating STAT3 activation, suggesting that AIM2 may be a promising therapeutic target for cerebral ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Wenzhong Hou, Jianping Yao, Junjie Liu, Xiaohong Lin, JueXian Wei, Xiaofan Yin, Hongbiao Huang, Xiaohui Chen, Guo-Yuan Yang, Xiaosong He
Summary: USP14 disrupts blood-brain barrier integrity and promotes neuroinflammation after ischemic stroke. Inhibition of USP14 with IU1 protects against blood-brain barrier leakage and attenuates neuronal loss caused by stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Brandon J. DeOre, Kiet A. Tran, Allison M. Andrews, Servio H. Ramirez, Peter A. Galie
Summary: The spike protein of SARS-CoV-2 disrupts the blood-brain barrier by upregulating ACE2 expression and activating RhoA, leading to potential neurological deficits in COVID-19 patients.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Clinical Neurology
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Helen M. Dewey, Gagan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Richard Leigh, Bruce C. Campbell
Summary: This study found that the severity of tissue injury within the infarct, as determined by assessing the integrity of the blood-brain barrier (BBB), is independently associated with improved functional outcome in patients with ischemic stroke. In addition to reducing infarct volume, reperfusion may also improve clinical outcome by reducing tissue injury severity within the infarct.
Article
Immunology
Guangtian Wang, Zhihui Li, Peng Lin, Huishu Zhang, Yanyan Wang, Tongshuai Zhang, Hui Wang, Heming Li, Lexun Lin, Yuehui Zhao, Lina Jia, Yang Chen, Hong Ji, Wenran Zhao, Zhongqiu Fu, Zhaohua Zhong
Summary: This study demonstrates the neuroprotective effects of si-Smox and its antioxidant properties in preserving BBB integrity and promoting angiogenesis in ischemic stroke. Activation of the Nrf2 pathway plays a key role in these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Food Science & Technology
Jinjin She, Nannan Feng, Wanglong Zheng, Hao Zheng, Peirong Cai, Hui Zou, Yan Yuan, Jianhong Gu, Zongping Liu, Jianchun Bian
Summary: The study demonstrated that exposure to Zearalenone (ZEA) resulted in severe testicular damage and a decrease in the expression of blood-testis barrier (BTB) junction-related proteins in a time-dependent manner, accompanied by an increase in autophagy-related proteins. In vitro, ZEA treatment led to an increase in cytoplasmic Ca2+ levels, autophagy markers LC3-II and p62 levels, and a decrease in BTB junction proteins, with the dislocation of the gap junction protein Cx43. Inhibition of autophagy or cytoplasmic Ca2+ was able to mitigate the effects of ZEA on BTB in TM4 cells.
Article
Engineering, Biomedical
Zhuang Tang, Shiyu Meng, Zhiling Song, Xiaoxue Yang, Xinzhi Li, Hui Guo, Meirong Du, Jun Chen, Yi Zhun Zhu, Xiaolin Wang
Summary: A biomimetic nanosystem (Leo@NM-Lipo) composed of neutrophil membrane-fused nanoliposomal leonurine (Leo) was constructed to target ischemic stroke (IS) therapy. Leo@NM-Lipo efficiently repaired the disrupted blood-brain barrier (BBB) and remodeled the cerebral microenvironment to reverse ischemia-reperfusion (I/R) injury. The nanosystem exhibited significant therapeutic effects by alleviating neuronal apoptosis, oxidative stress, neuroinflammation, and restoring BBB integrity in rats with transient middle cerebral artery occlusion (tMCAO).
MATERIALS TODAY BIO
(2023)
Article
Clinical Neurology
Juan Zhu, Zheqi Li, Zhong Ji, Yongming Wu, Yihua He, Kewei Liu, Yuan Chang, Yuqin Peng, Zhenzhou Lin, Shengnan Wang, Dongmei Wang, Kaibin Huang, Suyue Pan
Summary: The dynamic degradation and reconstruction of GCX may explain the biphasic changes in BBB permeability in ischemic stroke, and reveal the essential role of GCX in suppressing transcellular transport in brain endothelial cells to maintain BBB integrity. Targeting GCX may provide a novel strategy for managing BBB dysfunction and central nervous system drug delivery.
Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang
Summary: Blood-brain barrier (BBB) breakdown is a common feature of ischemic stroke. This study reveals that overexpression of mitochondrial ferritin (FtMt) can attenuate BBB disruption in an ischemia-reperfusion (I/R) injury model by inhibiting iron dysregulation and reactive oxygen species accumulation. These findings provide novel insights into the protective role of FtMt in maintaining BBB integrity during ischemic stroke.
Article
Neurosciences
Muyassar Mamtilahun, Zhenyu Wei, Chuan Qin, Yongting Wang, Yaohui Tang, Fan-xia Shen, Heng-Li Tian, Zhijun Zhang, Guo-Yuan Yang
Summary: NBP treatment significantly increased eNOS expression and surface blood flow in the brain, reduced brain edema and infarct volume, and improved neurological severity score. Furthermore, NBP attenuated Evans blue and IgG leakage and increased tight junction protein expression after 1 and 3 days of ischemic stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Shuai Zhang, Jing Zhao, Wei-Meng Sha, Xin-Pei Zhang, Jing-Yuan Mai, Perry F. Bartlett, Sheng-Tao Hou
Summary: This study found that EphA4 plays a critical role in the contraction and tight junction damage of brain microvascular endothelial cells during oxygen-glucose deprivation and reperfusion. The use of EphA4-Fc effectively reduces brain edema and improves neurological function recovery.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Harrison Rudd, Michal Toborek
Summary: HIV can cross the blood-brain barrier through a Trojan horse-like mechanism, leading to central nervous system infection. Latent HIV can evade detection by the immune system and antiretroviral therapy (ART), and work synergistically with ART to promote neuroinflammatory pathophysiology. Therefore, further research into novel therapeutic approaches is needed.
Article
Neurosciences
Yubin Liang, Pingping Song, Wei Chen, Xuemin Xie, Rixin Luo, Jiehua Su, Yunhui Zhu, Jiamin Xu, Rongrong Liu, Peizhi Zhu, Yusheng Zhang, Min Huang
Summary: Inhibition of caspase-1 can ameliorate ischemia-induced infarction, neurological deficits, and neuronal injury, while enhancing blood-brain barrier (BBB) permeability and integrity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Luc Bertrand, Madhavan Nair, Michal Toborek
CURRENT PHARMACEUTICAL DESIGN
(2016)
Article
Virology
Carolina Sanabria-Solano, Carmen Elena Gonzalez, Nicolas Richerioux, Luc Bertrand, Slimane Dridi, Anthony Griffiths, Yves Langelier, Angela Pearson
Article
Neurosciences
Ibolya E. Andras, Ana Leda, Marta Garcia Contreras, Luc Bertrand, Minseon Park, Marta Skowronska, Michal Toborek
MOLECULAR AND CELLULAR NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Ana R. Leda, Levy Dygert, Luc Bertrand, Michal Toborek
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Multidisciplinary Sciences
Luc Bertrand, Levi Dygert, Michal Toborek
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Surgery
Omar Picado, Levi Dygert, Francisco Igor Macedo, Dido Franceschi, Danny Sleeman, Alan S. Livingstone, Nipun Merchant, Danny Yakoub
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Sung Yong Eum, Dima Jaraki, Luc Bertrand, Ibolya E. Andras, Michal Toborek
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2014)
Article
Clinical Neurology
Jennifer A. Frontera, Dixon Yang, Ariane Lewis, Palak Patel, Chaitanya Medicherla, Vito Arena, Taolin Fang, Andres Andino, Thomas Snyder, Maya Madhavan, Daniel Gratch, Benjamin Fuchs, Alexa Dessy, Melanie Canizares, Ruben Jauregui, Betsy Thomas, Kristie Bauman, Anlys Olivera, Dhristie Bhagat, Michael Sonson, George Park, Rebecca Stainman, Brian Sunwoo, Daniel Talmasov, Michael Tamimi, Yingrong Zhu, Jonathan Rosenthal, Levi Dygert, Milan Ristic, Haruki Ishii, Eduard Valdes, Mirza Omari, Lindsey Gurin, Joshua Huang, Barry M. Czeisler, D. Ethan Kahn, Ting Zhou, Jessica Lin, Aaron S. Lord, Kara Melmed, Sharon Meropol, Andrea B. Troxel, Eva Petkova, Thomas Wisniewski, Laura Balcer, Chris Morrison, Shadi Yaghi, Steven Galetta
Summary: Long-term outcomes of COVID-19 hospitalized patients, particularly those with neurological complications, showed impairments in daily living activities, cognition, anxiety, depression, and sleep. Patients with neurological complications had significantly worse functional outcomes compared to those without.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Editorial Material
Clinical Neurology
Levi Dygert, Ariane Lewis
Summary: This paper examines two cases of patients with neurological problems, discussing the clash of beliefs on end-of-life care between physicians and family members and reflecting on how to best manage these disagreements. It emphasizes the importance of respecting patient autonomy when considering withdrawing treatment and the need for clinicians to ensure that surrogates are adequately educated about the principle of beneficence in decision-making about continuing life-sustaining treatment.
Letter
Clinical Neurology
Levi Dygert, Ariane Lewis
Article
Pharmacology & Pharmacy
Luc Bertrand, Michal Toborek
MOLECULAR PHARMACOLOGY
(2015)