SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation

SARS-COV2 Alters Blood Brain Barrier Integrity Contributing to Neuro-Inflammation

(2021) Jessica. L. Reynolds et al.   Journal of Neuroimmune Pharmacology

Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?

(2021) Adriano José Maia Chaves Filho et al.   Journal of Neuroimmune Pharmacology

Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations

(2021) Yuanyuan Qin et al.   JOURNAL OF CLINICAL INVESTIGATION

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

Delirium: a missing piece in the COVID-19 pandemic puzzle

(2020) Shane O’Hanlon et al.   AGE AND AGEING

Upregulation of angiotensin converting enzyme 2 by shear stress reduced inflammation and proliferation in vascular endothelial cells

(2020) Jiantao Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute lung injury: The therapeutic role of Rho kinase inhibitors

(2020) Farshad Abedi et al.   PHARMACOLOGICAL RESEARCH

ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19

(2020) Bruna G G Pinto et al.   JOURNAL OF INFECTIOUS DISEASES

Plausibility of therapeutic effects of Rho kinase inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19)

(2020) Farshad Abedi et al.   PHARMACOLOGICAL RESEARCH

SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients

(2020) Ashutosh Kumar et al.   MEDICAL HYPOTHESES

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary embolism

(2019) Xiaoling Xu et al.   THROMBOSIS RESEARCH

Disturbed flow disrupts the blood-brain barrier in a 3D bifurcation model

(2019) Nesrine Bouhrira et al.   Biofabrication

ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway

(2018) Cheng Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood−brain barrier permeability: Possible link to postoperative delirium and cognitive decline

(2015) Nimish K. Acharya et al.   BRAIN RESEARCH

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

(2015) Constantinos M. Mikelis et al.   Nature Communications

Angiotensin-(1–7)

(2014) Robson Augusto Santos   HYPERTENSION

Angiotensin II type-1 receptor regulates RhoA and Rho-kinase/ROCK activation via multiple mechanisms. Focus on “Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells”

(2009) Keita Kimura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

(2008) Masaru Yamamoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiotensin-converting enzyme 2 in the brain: properties and future directions

(2008) Huijing Xia et al.   JOURNAL OF NEUROCHEMISTRY