Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling

In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

(2012) Bilal S. Abuasal et al.   MOLECULAR PHARMACEUTICS

Utility of Physiologically Based Absorption Modeling in Implementing Quality by Design in Drug Development

(2011) Xinyuan Zhang et al.   AAPS Journal

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible

(2011) Micaela B. Reddy et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

(2011) Neil Parrott et al.   CLINICAL PHARMACOKINETICS

Application of PBPK modelling in drug discovery and development at Pfizer

(2011) Hannah M Jones et al.   XENOBIOTICA

Prediction of Oral Pharmacokinetics of cMet Kinase Inhibitors in Humans: Physiologically Based Pharmacokinetic Model Versus Traditional One-Compartment Model

(2010) S. Yamazaki et al.   DRUG METABOLISM AND DISPOSITION

Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality

(2010) Kevin Damman et al.   EUROPEAN JOURNAL OF HEART FAILURE

A Physiologically Based Pharmacokinetic (PBPK) Model for Predicting the Efficacy of Drug Overdose Treatment With Liposomes in Man

(2010) Brett A. Howell et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Customized In Silico Population Mimics Actual Population in Docetaxel Population Pharmacokinetic Analysis

(2010) Susan F. Hudachek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanistic Approaches to Predicting Oral Drug Absorption

(2009) Weili Huang et al.   AAPS Journal

Prediction of Biliary Excretion in Rats and Humans Using Molecular Weight and Quantitative Structure–Pharmacokinetic Relationships

(2009) Xinning Yang et al.   AAPS Journal

Modelling and PBPK Simulation in Drug Discovery

(2009) Hannah M. Jones et al.   AAPS Journal

When to Conduct a Renal Impairment Study During Drug Development: US Food and Drug Administration Perspective

(2009) S-M Huang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Predicting pKa

(2009) Adam C. Lee et al.   Journal of Chemical Information and Modeling

Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly

(2009) Chad M. Thompson et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

(2009) Agnès Poirier et al.   MOLECULAR PHARMACEUTICS

Low-dose Fixed Combination of Bisoprolol/Hydrochlorothiazide as First Line for Hypertension: A Review of the Rationale and Clinical Evidence

(2008) Dimitris P. Papadopoulos et al.   ANGIOLOGY

Identification of Intestinal Loss of a Drug through Physiologically Based Pharmacokinetic??Simulation of Plasma??Concentration-Time Profiles

(2008) Sheila Annie Peters   CLINICAL PHARMACOKINETICS

Directional Transcellular Transport of Bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 Cells but not in Renal Epithelial LLC-PK1 Cells

(2008) Katsutoshi Tahara et al.   Drug Metabolism and Pharmacokinetics

Clinical relevance of predictive physiologically based pharmacokinetic methods

(2008) Simon Thomas   Expert Opinion on Drug Discovery

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Calculation of Molecular Lipophilicity: State-of-the-Art and Comparison of LogP Methods on more than 96,000 Compounds

(2008) Raimund Mannhold et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS