Review
Cell Biology
Gaiqin Pei, Li Chen, Yang Wang, Chengqi He, Chenying Fu, Quan Wei
Summary: In recent decades, the treatment of cardiovascular and cerebrovascular diseases has advanced greatly, leading to more effective prevention of cardiovascular and cerebrovascular events. However, cardiac and cerebral atherothrombotic complications still cause significant morbidity and mortality worldwide. This article discusses the role of miR-182 in regulating various factors related to atherosclerosis, coronary artery disease, myocardial infarction, ischemia/reperfusion injury, organ transplant, cardiac hypertrophy, hypertension, heart failure, congenital heart disease, and cardiotoxicity. Additionally, it summarizes the current progress of miR-182 therapeutics in clinical development and highlights challenges that need to be addressed for clinical application in patients with cardiac disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marilesia Ferreira Souza, Ilce Mara Syllos Colus, Aline Simoneti Fonseca, Valquiria Casanova Antunes, Deepak Kumar, Luciane Regina Cavalli
Summary: MiR-182-5p plays a regulatory role in modulating aggressive tumor phenotypes in androgen-refractory prostate cancer cells by targeting epithelial-mesenchymal transition (EMT)-associated pathways.
Article
Biochemistry & Molecular Biology
Jiahe Xie, Cankun Zheng, Mengjia Shen, Weiling Lu, Mingjue Li, Mingyuan He, Lu Chen, Siyuan Ma, Yingqi Zhu, Hairuo Lin, Jiancheng Xiu, Wangjun Liao, Jianping Bin, Yulin Liao
Summary: Previous studies have shown that a woman's pregnancy is associated with post-reproductive longevity and nulliparity is linked to a higher risk of heart failure. This suggests that pregnancy may have a cardioprotective effect. This study aims to investigate the phenomenon of pregnancy-induced physiological hypertrophic preconditioning (PHP) and its mechanisms.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Jifei Wang, Wangjie Jiang, Shuochen Liu, Kuangheng Shi, Yaodong Zhang, Yananlan Chen, Jijun Shan, Yuming Wang, Xiao Xu, Changxian Li, Xiangcheng Li
Summary: The study found that miR-182-5p can be taken up by exosomes secreted from cholangiocarcinoma, promoting vascular endothelial cell proliferation, migration, and angiogenesis. Additionally, miR-182-5p also activates the PI3K/AKT/mTOR signaling pathway, leading to drug resistance in cholangiocarcinoma.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Nan Niu, Huangtai Miao, Hongmei Ren
Summary: This study investigates the diagnostic significance of miR-182-5p in myocardial infarction by studying its impact on myocardial apoptosis and function in both in vivo and in vitro models. The results demonstrate that miR-182-5p exacerbates myocardial injury and promotes apoptosis during myocardial infarction. Interventions aimed at reducing miR-182-5p levels may be crucial in halting the progression of myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Ichitaro Abe, Takeshi Terabayashi, Katsuhiro Hanada, Hidekazu Kondo, Yasushi Teshima, Yumi Ishii, Miho Miyoshi, Shintaro Kira, Shotaro Saito, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Kunio Yufu, Motoki Arakane, Tsutomu Daa, Dean Thumkeo, Shuh Narumiya, Naohiko Takahashi, Toshimasa Ishizaki
Summary: The study identified the pivotal role of mammalian homologue of Drosophila diaphanous (mDia) 1 in pressure overload-induced ventricular hypertrophy. Loss of mDia1 led to decreased cardiac hypertrophic responses and increased mortality rate in mice after aortic constriction, suggesting that mDia1 is crucial in compensatory cardiac hypertrophy in response to pressure overload.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Zaccagnini Germana, Greco Simona, Longo Marialucia, Maimone Biagina, Voellenkle Christine, Fuschi Paola, Carrara Matteo, Creo Pasquale, Maselli Davide, Tirone Mario, Mazzone Massimiliano, Gaetano Carlo, Spinetti Gaia, Martelli Fabio
Summary: miR-210 has a context-dependent regulation on the inflammatory response, with overexpression associated with improved angiogenesis and tissue repair. Infiltrating cells with mismatched miR-210 levels lead to a pro-fibrotic phenotype, impairing tissue repair, causing fibrosis, and dysfunctional angiogenesis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xuejun Zhao, Zijie Xia, Ziang Wang, Mengsi Zhou, Xuebing Qiu, Cheng Wang, Tian Xu, Qian Fang, Zhenping Ming, Huifen Dong
Summary: This study reveals that the downregulation of miR-182-5p contributes to the alleviation of liver fibrosis caused by Schistosoma japonicum infection. Knockdown of miR-182-5p leads to increased expression of immunosuppressive protein TTP, which destabilizes inflammatory factor mRNA and attenuates liver fibrosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Cell Biology
Jiangquan Liao, Mingjing Shao, Yan Wang, Peng Yang, Dongliang Fu, Mengru Liu, Tong Gao, Kangkang Wei, Xianlun Li, Jinhang Du
Summary: This study investigates the regulatory effect of Xuesaitong (XST) and miR-3158-3p on angiogenesis. XST is found to enhance cardiac function and reduce fibrosis in mice. It promotes cell viability and angiogenesis, as well as inhibits the expression of Nur77. In conclusion, XST inhibits miR-3158-3p targeting Nur77 to facilitate myocardial angiogenesis in mice with myocardial infarction.
Article
Oncology
Shuibo Gao, Haixia Gao, Liping Dai, Yongjun Han, Zhen Lei, Xinzhou Wang, Hongbo Chang, Shanshan Liu, Zhentao Wang, Haibin Tong, Hong Wu
Summary: miR-126 regulates angiogenesis during MI through HIF-1α and may serve as a potential therapeutic target.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Xia Li, Yalei Jin
Summary: This study revealed the important regulatory role of miR-182-5p in ischemia-reperfusion injury, by targeting STK17A to regulate myocardial cell apoptosis and oxidative stress response, thereby protecting the myocardium from I/R injury.
Article
Multidisciplinary Sciences
Zahra Saadatian, Yaser Mansoori, Lida Nariman-Saleh-Fam, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Ziba Nariman-Saleh-Fam
Summary: This study evaluated the alteration of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with coronary artery stenosis and insignificant coronary artery stenosis compared to healthy individuals. The results showed that three of these miRNAs have the potential to differentiate between coronary artery stenosis patients and healthy individuals, suggesting they could be novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Xuejun Wang, Zijie Cheng, Jia Xu, Mengwen Feng, Hao Zhang, Li Zhang, Lingmei Qian
Summary: This study aimed to investigate the regulatory role of differentially-expressed circular RNAs (circRNAs) in mouse cardiomyocytes during doxorubicin-induced cardiotoxicity. The expression profiles of circRNAs were significantly altered, with circArhgap12 playing a competitive role among endogenous RNAs in regulating cardiotoxicity. Further analysis revealed that circArhgap12 promoted apoptosis and oxidative stress by sponging miR-135a-5p, suggesting a potential therapeutic target in doxorubicin-induced cardiotoxicity.
Article
Cell & Tissue Engineering
Zhipeng Pei, Jinfeng Cen, Xinkang Zhang, Chuchu Gong, Mingxue Sun, Wenqi Meng, Guanchao Mao, Jingjing Wan, Bingyue Hu, Xiaowen He, Qingqiang Xu, Hua Han, Kai Xiao
Summary: This study aims to demonstrate that extracellular vesicles derived from human umbilical cord mesenchymal stromal cells (hucMSC-EVs) have therapeutic effects on sulfur mustard-induced acute lung injury (ALI) and to explain the underlying mechanism. The results show that miR-146a-5p delivered by hucMSC-EVs targets TRAF6 to negatively regulate inflammation in SM-induced ALI, thus exerting an anti-inflammatory effect. Therefore, hucMSC-EVs treatment may be a promising clinical therapeutic option after sulfur mustard exposure.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Fisheries
Yingrui Li, Lin Su, Baoshan Guo, Shun Zhou, Chao Li, Yunji Xiu
Summary: Pathogens infection induces intestinal inflammatory processes. MicroRNAs in teleost serve as vital regulators in innate immunity responses against pathogen infection. MiR-144-5p is identified as negative regulator in teleost against bacterial infection. It down-regulates inflammation-related cytokines by targeting Hsp90 alpha, ultimately promoting bacterial infection.
Article
Peripheral Vascular Disease
Patrick Fournier, Claire Viallard, Agnieszka Dejda, Przemyslaw Sapieha, Bruno Larrivee, Isabelle Royal
Article
Biochemistry & Molecular Biology
Claire Viallard, Cindy Audiger, Natalija Popovic, Naoufal Akla, Kevin Lanthier, Isaac Legault-Navarrete, Heather Melichar, Santiago Costantino, Sylvie Lesage, Bruno Larrivee
Article
Public, Environmental & Occupational Health
Mohammed Imran Ghare, Daniela Tirziu, Jinnette Dawn Abbott, Elissa Altin, Yiping Yang, Vivian Ng, Cindy Grines, Alexandra Lansky
JOURNAL OF WOMENS HEALTH
(2020)
Article
Multidisciplinary Sciences
Hamid Ebrahimi Orimi, Sayadeh Sara Hosseini Kolkooh, Erika Hooker, Sivakumar Narayanswamy, Bruno Larrivee, Christos Boutopoulos
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Cindy Lora Gil, Nathalie Henley, Francois A. Leblond, Naoufal Akla, Louis-Philippe Laurin, Virginie Royal, Casimiro Gerarduzzi, Vincent Pichette, Bruno Larrivee
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Louis Masclef, Oumaima Ahmed, Benjamin Estavoyer, Bruno Larrivee, Nathalie Labrecque, Anastasia Nijnik, El Bachir Affar
Summary: BAP1 gene is a major tumor suppressor mutated in various human malignancies, associated with high incidence of cancers like mesothelioma and uveal melanoma. It plays essential roles in cell processes and regulation of chromatin-associated activities, highlighting its significance in cancer development. BAP1 mutations are linked to gene-environment interactions and its intricate functions are tightly regulated by various signaling pathways.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Medicine, Research & Experimental
Natalija Popovic, Erika Hooker, Andrea Barabino, Anthony Flamier, Frederic Provost, Manuel Buscarlet, Gilbert Bernier, Bruno Larrivee
Summary: COCO is a novel inhibitor of angiogenesis that can inhibit pathological retinal and choroidal vascularization, potentially representing a therapeutic option for neovascular ocular diseases.
EMBO MOLECULAR MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Alexandra Lansky, Hyung Chun, Cody Pietras, Yasin Hussain
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yasin Hussain, Samantha Gaston, Johnathan Kluger, Tayyab Shah, Yiping Yang, Daniela Tirziu, Alexandra Lansky
Summary: This study aimed to investigate the impact of ultrathin drug eluting stents on long term outcomes in patients with coronary artery disease. The results showed a significant reduction in target lesion failure at 2 and 3 years with the use of ultrathin DES.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Multidisciplinary Sciences
Janna Krueger, Francois Santinon, Alexandra Kazanova, Mark E. Issa, Bruno Larrivee, Richard Kremer, Catalin Milhalcioiu, Christopher E. Rudd
Summary: The study found that the use of HCQ alone or in combination with AZ reduced the therapeutic benefit of anti-PD-1 in cancer immunotherapy without causing harm to untreated tumors. Mechanistically, HCQ inhibited PD-L1 expression on tumor cells and the increase in TILs induced by anti-PD-1 treatment.
Article
Medicine, Research & Experimental
Hyung J. Chun, Elias Coutavas, Alexander Pine, Alfred Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, Anne Mathews, Brian Stephenson, Loretta G. Que, Patty J. Lee, Bryan D. Kraft
Summary: This study found that biological factors related to neutrophil activation, fibrosis signaling, and alveolar repair may be novel therapeutic or prognostic targets for individuals recovering from COVID-19 with persistent respiratory symptoms.
Article
Cardiac & Cardiovascular Systems
Mehdi H. Shishehbor, Thomas Zeller, Martin Werner, Marianne Brodmann, Helen Parise, Andrew Holden, Michael Lichtenberg, Sahil A. Parikh, Vikram S. Kashyap, Cody Pietras, Daniela Tirziu, Shiva Ardakani, Ulrich Beschorner, Prakash Krishnan, Khusrow A. Niazi, Andreas U. Wali, Alexandra J. Lansky
Summary: The second-generation Chocolate Touch DCB demonstrated superior efficacy and safety compared to Lutonix DCB in the treatment of femoropopliteal disease.
Article
Cardiac & Cardiovascular Systems
Alexandra J. Lansky, Daniela Tirziu, Jeffrey W. Moses, Cody Pietras, E. Magnus Ohman, William W. O'Neill, Mercedes M. Ekono, Cindy L. Grines, Helen Parise
Summary: This study compared the outcomes and costs of Impella and IABP support for high-risk PCI in real-world practice. After propensity adjustment, Impella use was associated with improved survival and reduced myocardial infarction and cardiogenic shock.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Claudia See, Yanting Wang, Haocheng Huang, Helen Parise, Yiping Yang, Daniela Tirziu, Dominic P. P. Francese, Nikolaos Papoutsidakis, Eric Bader, Ryan K. K. Kaple, Michael Cleman, Alexandra J. J. Lansky, John K. K. Forrest
Summary: This study analyzed 927 patients who underwent transcatheter aortic valve replacement (TAVR) and found that 42.3% of patients developed conduction disturbances within 7 days postoperatively, with 38% of them persisting. Patients with persistent conduction disturbances were more likely to receive pacemaker implantation within 7 days and had a higher risk of cardiac-related and all-cause mortality at 1-year follow-up.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2023)
Review
Urology & Nephrology
Cindy Lora Gil, Erika Hooker, Bruno Larrivee
Summary: Diabetes-related complications, such as diabetic kidney disease, are a major cause of morbidity and mortality worldwide. Chronic hyperglycemia can lead to endothelial cell dysfunction, disrupting the molecular crosstalk between endothelium and podocytes. Current therapies primarily focus on glycemia and blood pressure control, but overlook the importance of targeting endothelial dysfunction.