Systems pharmacology exploration of botanic drug pairs reveals the mechanism for treating different diseases

Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination

(2016) Xiaoqiang Sun et al.   Oncotarget

NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning

(2016) Xing Chen et al.   PLoS Computational Biology

Effects of Eleutheroside B and Eleutheroside E on activity of cytochrome P450 in rat liver microsomes

(2014) Sixun Guo et al.   BMC Complementary and Alternative Medicine

The Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects against Dyslipidemia-Related Kidney Injury in Apolipoprotein E Knockout Mice

(2014) Jingjing Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells

(2013) Seung-Hyun Jung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction

(2013) Yao Yao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice

(2013) Hui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

A network-based analysis of the types of coronary artery disease from traditional Chinese medicine perspective: Potential for therapeutics and drug discovery

(2013) Wei Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease

(2012) Xia Wang et al.   Evidence-based Complementary and Alternative Medicine

Inducible Nitric Oxide Synthase Inhibition as a Target for the Treatment of Vascular Dysfunction in Hypertension

(2012) Stefany B.A. Cau et al.   HYPERTENSION

A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

(2012) Xue Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

(2012) Weiyang Tao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Drug–target interaction prediction by random walk on the heterogeneous network

(2012) Xing Chen et al.   Molecular BioSystems

The Comparative Toxicogenomics Database: update 2013

(2012) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

A Systematic Prediction of Multiple Drug-Target Interactions from Chemical, Genomic, and Pharmacological Data

(2012) Hua Yu et al.   PLoS One

A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment

(2012) Xiuxiu Li et al.   PLoS One

Quantitative High-Throughput Screening for Chemical Toxicity in a Population-Based In Vitro Model

(2012) Eric F. Lock et al.   TOXICOLOGICAL SCIENCES

Metabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach

(2011) Atsushi Fukushima et al.   BMC Systems Biology

Abstract 5509: Identification of synergistic drugs using combination high-throughput screening

(2011) Richard J. Rickles et al.   CANCER RESEARCH

Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall on osteoarthritis disease: A computational pharmacology approach

(2011) Hong-zhi Ye et al.   Chinese Journal of Integrative Medicine

Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension

(2011) Xiaoyan Zhou et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

An integrated approach for management of Cyperus rotundus (purple nutsedge) in soybean–wheat cropping system

(2011) Mukesh Kumar et al.   CROP PROTECTION

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

STITCH 3: zooming in on protein-chemical interactions

(2011) M. Kuhn et al.   NUCLEIC ACIDS RESEARCH

Confidence from uncertainty - A multi-target drug screening method from robust control theory

(2010) Camilla Luni et al.   BMC Systems Biology

Snazer: the simulations and networks analyzer

(2010) Tommaso Mazza et al.   BMC Systems Biology

Biochemical network-based drug-target prediction

(2010) Edda Klipp et al.   CURRENT OPINION IN BIOTECHNOLOGY

Virtual screening with AutoDock: theory and practice

(2010) Sandro Cosconati et al.   Expert Opinion on Drug Discovery

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

(2010) Jose L. Medina-Franco et al.   MOLECULAR DIVERSITY

HIT: linking herbal active ingredients to targets

(2010) H. Ye et al.   NUCLEIC ACIDS RESEARCH

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Leonurine Protects Middle Cerebral Artery Occluded Rats Through Antioxidant Effect and Regulation of Mitochondrial Function

(2010) Kok Poh Loh et al.   STROKE

Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation

(2009) Rasmus Aamand et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Synergistic therapeutic actions of herbal ingredients and their mechanisms from molecular interaction and network perspectives

(2009) X.H. Ma et al.   DRUG DISCOVERY TODAY

Mitogen-activated protein kinases in hemostasis and thrombosis

(2008) F. ADAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Finding multiple target optimal intervention in disease-related molecular network

(2008) Kun Yang et al.   Molecular Systems Biology

Tanshinone IIB, a primary active constituent fromSalvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosisin vitro

(2008) Xue-Qing Yu et al.   PHYTOTHERAPY RESEARCH

Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin

(2008) Günter Seelinger et al.   PLANTA MEDICA

Comparative molecular dynamics simulations of histone deacetylase-like protein: Binding modes and free energy analysis to hydroxamic acid inhibitors

(2008) Chunli Yan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE