The Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects against Dyslipidemia-Related Kidney Injury in Apolipoprotein E Knockout Mice

The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms

(2014) Yanmei Zeng et al.   Cardiovascular Diabetology

DPP-4 inhibition with alogliptin on top of angiotensin II type 1 receptor blockade ameliorates albuminuria via up-regulation of SDF-1^|^alpha; in type 2 diabetic patients with incipient nephropathy

(2013) Hiroki Fujita et al.   ENDOCRINE JOURNAL

Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: Role of GLP-1 and GLP-1 receptor

(2013) Dalia M. Abd El Motteleb et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

High Fat Diet Causes Renal Fibrosis in LDLr-null Mice Through MAPK-NF-κB Pathway Mediated by Ox-LDL

(2013) Yao Dai et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF-β/Smad3 Pathway

(2013) Xin-Zhong Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction

(2013) Yen-Ta Chen et al.   Journal of Translational Medicine

HDAC Dependent Transcriptional Repression of Bmp-7 Potentiates TGF-β Mediated Renal Fibrosis in Obstructive Uropathy

(2013) Scott R. Manson et al.   JOURNAL OF UROLOGY

Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation

(2013) Xiang Gao et al.   KIDNEY & BLOOD PRESSURE RESEARCH

TGF-β-induced signaling circuit loops mediated by microRNAs as new therapeutic targets for renal fibrosis?

(2013) Mitsuo Kato   KIDNEY INTERNATIONAL

Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury

(2013) Anne-Emilie Declèves et al.   KIDNEY INTERNATIONAL

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential

(2013) Hiroki Fujita et al.   KIDNEY INTERNATIONAL

Blocking the Class I Histone Deacetylase Ameliorates Renal Fibrosis and Inhibits Renal Fibroblast Activation via Modulating TGF-Beta and EGFR Signaling

(2013) Na Liu et al.   PLoS One

Dipeptidyl peptidase IV inhibitor attenuates kidney injury in rat remnant kidney

(2013) Kwon Wook Joo et al.   BMC Nephrology

DPP-4 Inhibitors and Lipids: Systematic Review and Meta-Analysis

(2012) Matteo Monami et al.   ADVANCES IN THERAPY

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

(2012) Hui Yao Lan   International Journal of Biological Sciences

A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E–Deficient Mice

(2012) Junichi Matsubara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Renal and Cardiac Effects of DPP-4 Inhibitors – from Preclinical Development to Clinical Research

(2012) Berthold Hocher et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Inhibitors/antagonists of TGF-  system in kidney fibrosis

(2012) M. Yanagita   NEPHROLOGY DIALYSIS TRANSPLANTATION

GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

(2012) Edwin T. Parlevliet et al.   PLoS One

Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

(2011) Francisco J. López-Hernández et al.   CELL AND TISSUE RESEARCH

Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes

(2011) A. J. Tremblay et al.   DIABETES OBESITY & METABOLISM

Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)

(2011) Cristina Mega et al.   Experimental Diabetes Research

HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation

(2011) José Augusto Nogueira-Machado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet

(2011) A.-E. Decleves et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glucagon-like peptide–1 suppresses advanced glycation end product–induced monocyte chemoattractant protein–1 expression in mesangial cells by reducing advanced glycation end product receptor level

(2011) Yuji Ishibashi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α pathway

(2011) Hyun Wha Chung et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

(2010) Christian Rask-Madsen et al.   Cell Metabolism

Sitagliptin

(2010) Sohita Dhillon   DRUGS

Effect of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitor (Vildagliptin) on Peripheral Nerves in Streptozotocin-induced Diabetic Rats

(2009) Heung Yong Jin et al.   ARCHIVES OF MEDICAL RESEARCH

Tumor Necrosis Factor–Like Weak Inducer of Apoptosis (TWEAK) Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice

(2009) Begoña Muñoz-García et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice

(2009) J. Hsieh et al.   DIABETOLOGIA