Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

(2010) Kyle T. Pfaffenbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

(2010) Sophie C. Cazanave et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes

(2010) Sandhya Narasimhan et al.   CLINICAL BIOCHEMISTRY

Nonalcoholic Fatty Liver Disease: A Review and Update

(2010) Jeffrey R. Lewis et al.   DIGESTIVE DISEASES AND SCIENCES

Serum Apoptotic Caspase Activity in Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

(2010) George V. Papatheodoridis et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis

(2010) Yuko Akazawa et al.   JOURNAL OF HEPATOLOGY

Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin

(2010) C. L. Gentile et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bcl-2 family on guard at the ER

(2009) Eva Szegezdi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells

(2009) Kamila S. Gwiazda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

(2009) Hirokazu Sugimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

(2009) Yuichiro Shimizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular responses to endoplasmic reticulum stress and apoptosis

(2009) Vanya I. Rasheva et al.   APOPTOSIS

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα

(2009) Hirosuke Danno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

The role of the lipogenic pathway in the development of hepatic steatosis

(2009) C. Postic et al.   DIABETES & METABOLISM

Inhibition of Nuclear Factor-κB or Bax Prevents Endoplasmic Reticulum Stress- But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells

(2009) Morten F. Tonnesen et al.   ENDOCRINOLOGY

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Decreased survival of subjects with elevated liver function tests during a 28-year follow-up

(2009) Cecilia Söderberg et al.   HEPATOLOGY

Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance

(2009) Béatrice Bailly-Maitre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis

(2009) Shaikh Mizanoor Rahman et al.   JOURNAL OF LIPID RESEARCH

Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

(2009) Yuren Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Liver NF-κB and AP-1 DNA Binding in Obese Patients

(2009) Luis A. Videla et al.   Obesity

Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment

(2008) Christine Carter-Kent et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans

(2008) Sara Rigazio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

(2008) Nobuyuki Tamaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice

(2008) Seiichi Oyadomari et al.   Cell Metabolism

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and  -Cell Death

(2008) D. S. Luciani et al.   DIABETES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Hepatocyte nuclear factor 4α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

(2008) Jennifer Luebke-Wheeler et al.   HEPATOLOGY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects

(2008) Neeraj K. Sharma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

(2008) Herbert Tilg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY