First total synthesis of cyclodepsipeptides clavatustide A and B and their enantiomers

Targeting protein−protein interfaces using macrocyclic peptides

(2015) Meng Gao et al.   BIOPOLYMERS

Selection-based discovery of macrocyclic peptides for the next generation therapeutics

(2015) Tomomi Morioka et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Zn-Driven Discovery of a Hydrothermal Vent Fungal Metabolite Clavatustide C, and an Experimental Study of the Anti-Cancer Mechanism of Clavatustide B

(2014) Panpan Ye et al.   Marine Drugs

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two Novel Hepatocellular Carcinoma Cycle Inhibitory Cyclodepsipeptides from a Hydrothermal Vent Crab-Associated Fungus Aspergillus clavatus C2WU

(2013) Wei Jiang et al.   Marine Drugs

Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles

(2013) Xufen Yu et al.   MOLECULES

Macrocycles in new drug discovery

(2012) Jamie Mallinson et al.   Future Medicinal Chemistry

Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

(2012) Guadalupe-Miroslava Suarez-Jimenez et al.   Marine Drugs

Thermodynamic and Structural Effects of Macrocyclic Constraints in Protein−Ligand Interactions

(2010) John E. DeLorbe et al.   ACS Medicinal Chemistry Letters

Cyclodepsipeptides - Potential Drugs and Lead Compounds in the Drug Development Process

(2009) R. Lemmens-Gruber et al.   CURRENT MEDICINAL CHEMISTRY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Epiquinamide: A Poison That Wasn’t from a Frog That Was(1)

(2009) Richard W. Fitch et al.   JOURNAL OF NATURAL PRODUCTS

Purity−Activity Relationships of Natural Products: The Case of Anti-TB Active Ursolic Acid

(2008) Birgit U. Jaki et al.   JOURNAL OF NATURAL PRODUCTS

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY