Review
Engineering, Biomedical
Osamu Suzuki, Ryo Hamai, Susumu Sakai
Summary: Octacalcium phosphate (OCP), as a precursor of bone apatite crystals, exhibits highly osteoconductive properties and activates bone tissue-related cells, promoting bone formation. The conversion of OCP increases its stimulatory capacity by hydrolysis toward Ca-deficient hydroxyapatite, resulting in increased surface area and adsorption affinity. Introducing structural defects through co-precipitation with gelatin controls the dissolution rate, enhancing material biodegradation and osteogenecity. Controlling the biodegradation rate is crucial for optimizing the osteogenecity of OCP materials.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Itsuki Oizumi, Ryo Hamai, Yukari Shiwaku, Yu Mori, Takahisa Anada, Kazuyoshi Baba, Naohisa Miyatake, Soshi Hamada, Kaori Tsuchiya, Shin-Nosuke Nishimura, Eiji Itoi, Osamu Suzuki
Summary: This study investigated the effect of the simultaneous hydrolysis of octacalcium phosphate (OCP) and poly (lactic-co-glycolic acid) (PLGA) on osteoconductivity. Increasing OCP dose was found to lead to higher weight loss of PLGA and lower glass transition temperature of PLGAs. OCP/PLGA composites demonstrated enhanced bone formation and regenerative capacity in femoral defects.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Dingli Xu, Kaifeng Gan, Yang Wang, Zeting Wu, Yulong Wang, Song Zhang, Yujie Peng, Xuguang Fang, Hua Wei, Yansheng Zhang, Weihu Ma, Jing Chen
Summary: In this study, the BPN-DFO hydrogel was used to treat bone delay union and achieved satisfactory regeneration results in vitro and in vivo. The BPN-DFO hydrogel improved osteogenesis and neovascularization, and the improved bone regeneration was associated with the BMP/Runx2 pathway. This suggests that the BPN-DFO hydrogel has the potential to be a tissue engineering material for ischemic bone defect treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Orthopedics
Cheol-Hee Jeong, Jooseong Kim, Hyun Sil Kim, Song-Yi Lim, Dawool Han, Aaron J. Huser, Sang Bae Lee, Yeonji Gim, Jeong Hyun Ji, Dohun Kim, Amaal M. Aldosari, Kyelim Yun, Yoon Hae Kwak
Summary: In this study, three types of OCPs were compared to commercially available 8-TCP for their potential to promote bone formation in rat tibias with defects. The results showed that OCP/Alg was equivalent to 8-TCP in promoting bone bridge formation and had better biodegradability. OCP/Col accelerated bone formation in defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Review
Medicine, General & Internal
Yu Mori, Ryo Hamai, Toshimi Aizawa, Osamu Suzuki
Summary: Bone grafting is commonly used in clinical settings to treat bone defects. The development of bone graft substitutes, such as Octacalcium phosphate (OCP), has shown promise in achieving superior bone formation ability compared to autogenous bone grafting. OCP can be used in composite forms with natural polymers like collagen and gelatin to enhance its usability and osteogenic potential. This review discusses the development and preclinical results of OCP and OCP/gelatin (OCP/Gel) composites, and the potential future applications in orthopedics.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Article
Veterinary Sciences
Ahmed Abdelrahiem Sadek, Mahmoud Abd-Elkareem, Hani Nasser Abdelhamid, Samia Moustafa, Kamal Hussein
Summary: The UiO-66 nanomaterial demonstrates excellent cytocompatibility and stimulates osteoblast functions, indicating its potential as a biomaterial for bone tissue engineering. In vivo experiments show enhanced osteogenesis and healing of bone defects, making UiO-66 a promising candidate for bone repair.
BMC VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Ye Li, Kegong Xie, Chong Wang, Chengliang Yang, Ke Huang, Feng Li, Chuanchuan Zheng, Jian Chen, Shujun Dong, Guangfeng Deng, Gege Huang, Qiaoyan Lu, Jia Liu, Kai Li, Yujin Tang, Liqiang Wang
Summary: The study developed a porous CFZ/β-tricalcium phosphate/poly lactic-co-glycolic acid scaffold for treating critical-sized bone defects, showing promising results in promoting bone and blood vessel growth, and demonstrating for the first time that CFZ-loaded scaffolds could treat nonunion of bone defect by activating the Wnt/β-catenin signaling pathway.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Biotechnology & Applied Microbiology
Shuang Wu, Yong-Seok Jang, Min-Ho Lee
Summary: The application of calcium phosphates (CaPs) coating obtained by alkali-hydrothermal treatment on magnesium surfaces can improve surface properties and enhance the cell affinity of magnesium. The magnesium mesh coated with CaP showed better osteointegration and bone affinity in guided bone regeneration in rat calvaria compared to untreated magnesium mesh.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Seok-Jun Kim, Joo-Seong Kim, Woong Kim, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the efficacy of using Bontree (R) for LSFE through radiographic and histomorphometric analysis. The results showed that Bontree (R) is effective in promoting new bone formation.
Article
Chemistry, Multidisciplinary
Joo-Seong Kim, Tae-Sik Jang, Suk-Young Kim, Won-Pyo Lee
Summary: This study evaluated the effect of a commercialized octacalcium phosphate (OCP)-based synthetic bone substitute material (Bontree(R)) in vitro, in vivo, and in clinical cases. Bontree(R) suppressed RANKL and increased ALP activity, showing a high new bone formation ability. Clinical application demonstrated a 100% success rate for ridge or sinus augmentation using Bontree(R).
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Ceramics
Antonia Ressler, Irena Ivanisevic, Andreja Zuzic, Nicolas Somers
Summary: Octacalcium phosphate shows promising properties for bone tissue regeneration, but hydroxyapatite is still considered the most promising material. Many studies confirm the superior performance of octacalcium phosphate in vivo.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Juliana S. Ribeiro, Eliseu A. Muenchow, Ester A. F. Bordini, Nathalie S. Rodrigues, Nileshkumar Dubey, Hajime Sasaki, John C. Fenno, Steven Schwendeman, Marco C. Bottino
Summary: This study engineered cytocompatible and injectable antibiotic-laden fibrous microparticles GelMA hydrogels for endodontic infection ablation. The modified GelMA with antibiotic-laden fibrous microparticles increased the hydrogel swelling ratio and degradation rate, while exhibiting low toxicity to cells and effective antibiofilm effects against bacteria. Overall, these engineered hydrogels show promising prospects for clinical treatment of endodontic infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Julia Gao, Yingchao Su, Yi-Xian Qin
Summary: This study compared the in vitro and in vivo degradation and biocompatibility behaviors of magnesium alloys with calcium phosphate coatings, showing that the CaP coating significantly improved biodegradation behavior and biocompatibility of the Mg alloy. In vitro tests were found to be a quick screening tool for biodegradation rate, with the in vivo degradation rate being slower than in vitro immersion degradation rate.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Sei Tsutsui, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Hajime Yamazaki, Osamu Suzuki
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Yuko Sai, Yukari Shiwaku, Takahisa Anada, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
ACTA BIOMATERIALIA
(2018)
Article
Engineering, Biomedical
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Chemistry, Multidisciplinary
Naru Shiraishi, Risa Ishiko-Uzuka, Kenta Takahashi, Toru Ogawa, Takahisa Anada, Osamu Suzuki, Takashi Goto, Keiichi Sasaki
APPLIED SCIENCES-BASEL
(2019)
Article
Biochemistry & Molecular Biology
Takahisa Anada, Chi-Chun Pan, Alexander M. Stahl, Satomi Mori, Junji Fukuda, Osamu Suzuki, Yunzhi Yang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Engineering, Biomedical
Osamu Suzuki
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Engineering, Biomedical
Yukari Shiwaku, Kaori Tsuchiya, Linghao Xiao, Osamu Suzuki
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Engineering, Biomedical
Tomoya Sato, Takahisa Anada, Ryo Hamai, Yukari Shiwaku, Kaori Tsuchiya, Susumu Sakai, Kazuyoshi Baba, Keiichi Sasaki, Osamu Suzuki
ACTA BIOMATERIALIA
(2019)
Article
Engineering, Biomedical
Tsuyoshi Kurobane, Yukari Shiwaku, Takahisa Anada, Ryo Hamai, Kaori Tsuchiya, Kazuyoshi Baba, Masahiro Iikubo, Tetsu Takahashi, Osamu Suzuki
ACTA BIOMATERIALIA
(2019)
Article
Chemistry, Physical
Ryo Hamai, Kaori Tsuchiya, Osamu Suzuki
Article
Dentistry, Oral Surgery & Medicine
Naru Shiraishi, Hiroshi Masumoto, Kenta Takahashi, Taichi Tenkumo, Takahisa Anada, Osamu Suzuki, Toru Ogawa, Keiichi Sasaki
DENTAL MATERIALS JOURNAL
(2020)
Article
Cell & Tissue Engineering
Tadashi Kawai, Shinji Kamakura, Keiko Matsui, Masayuki Fukuda, Hiroshi Takano, Mitsuyoshi Iino, Shigeo Ishikawa, Hiromasa Kawana, Tomoya Soma, Eisaku Imamura, Hideki Kizu, Aya Michibata, Izumi Asahina, Keiichiro Miura, Norifumi Nakamura, Toshiro Kibe, Osamu Suzuki, Tetsu Takahashi
JOURNAL OF TISSUE ENGINEERING
(2020)
Review
Dentistry, Oral Surgery & Medicine
Osamu Suzuki, Yukari Shiwaku, Ryo Hamai
DENTAL MATERIALS JOURNAL
(2020)
Article
Nanoscience & Nanotechnology
Kazuyoshi Baba, Yukari Shiwaku, Ryo Hamai, Yu Mori, Takahisa Anada, Kaori Tsuchiya, Itsuki Oizumi, Naohisa Miyatake, Eiji Itoi, Osamu Suzuki
ACS APPLIED BIO MATERIALS
(2020)
Review
Dentistry, Oral Surgery & Medicine
Yasuyuki Sasano, Megumi Nakamura, Akiko Henmi, Hiroshi Okata, Osamu Suzuki, Atsuko Kayaba, Miyuki Mayanagi
JOURNAL OF ORAL BIOSCIENCES
(2019)