Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

(2016) Ming-Yu Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51

(2016) Wei Lv et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

(2016) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

(2015) Nicholas S. Adamson Barnes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Organic Carbamates in Drug Design and Medicinal Chemistry

(2015) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

(2015) Mourad Chioua et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Endocannabinoid signalling and the deteriorating brain

(2015) Vincenzo Di Marzo et al.   NATURE REVIEWS NEUROSCIENCE

Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats

(2015) James Lim et al.   NEUROPSYCHOPHARMACOLOGY

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

(2015) Margherita Brindisi et al.   MedChemComm

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

(2015) Margherita Brindisi et al.   Scientific Reports

Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering withβ-Amyloid Aggregation

(2014) Simone Brogi et al.   CNS Neuroscience & Therapeutics

The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184

(2014) Alexandre Seillier et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase

(2013) Niina Aaltonen et al.   CHEMISTRY & BIOLOGY

Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Antiwithdrawal Effects in Morphine-Dependent Mice

(2013) Divya Ramesh et al.   NEUROPSYCHOPHARMACOLOGY

“Redundancy” of Endocannabinoid Inactivation: New Challenges and Opportunities for Pain Control

(2012) Fabiana Piscitelli et al.   ACS Chemical Neuroscience

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties

(2012) Stefania Butini et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders

(2012) Matthew Hill et al.   CNS & Neurological Disorders-Drug Targets

Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases

(2012) Stefania Butini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase – Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology

(2012) Vinogran Naidoo et al.   Neurotherapeutics

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Differential Role of Anandamide and 2-Arachidonoylglycerol in Memory and Anxiety-like Responses

(2011) Arnau Busquets-Garcia et al.   BIOLOGICAL PSYCHIATRY

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)

(2011) Katerina Otrubova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase

(2011) Mauro Mileni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils

(2011) Sandra Gemma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II

(2010) Vanessa Desplat et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitors Produce Anti-Allodynic Effects in Mice Through Distinct Cannabinoid Receptor Mechanisms

(2010) Steven G. Kinsey et al.   JOURNAL OF PAIN

Intracellular trafficking of anandamide: new concepts for signaling

(2010) Mauro Maccarrone et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

(2009) Geoffray Labar et al.   CHEMBIOCHEM

Novel, Potent, and Selective Quinoxaline-Based 5-HT3Receptor Ligands. 1. Further Structure−Activity Relationships and Pharmacological Characterization

(2009) Stefania Butini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific Targeting of Peripheral Serotonin 5-HT3Receptors. Synthesis, Biological Investigation, and Structure−Activity Relationships

(2009) Elena Morelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants

(2009) Matthew N. Hill et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

(2008) John M. Keith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cannabinoid Receptors: Where They are and What They do

(2008) K. Mackie   JOURNAL OF NEUROENDOCRINOLOGY

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

The complications of promiscuity: endocannabinoid action and metabolism

(2007) S P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY