Article
Pharmacology & Pharmacy
Qingjie Mu, Kaixuan Lv, Jielun Yu, Shangmin Chu, Lichun Zhang, Lingyu Kong, Linlin Zhang, Yan Tian, Xiaopeng Jia, Benhong Liu, Youzhen Wei, Nana Yang
Summary: This study found that hydrogen can repair the proliferation, migration, and tube formation dysfunctions of lipopolysaccharide (LPS)-induced bone marrow-derived endothelial progenitor cells (EPCs). This repairment is mediated by the PI3K/AKT/eNOS signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haijun Kang, Dongmei Huang, Heng Li, Xuejun Deng, Siyuan Liu, Wenjun Gou, Linglin Liu, Yuyan Qiu, Xu Yang
Summary: This study found that the long non-coding RNA lncNALT plays an important role in the pathogenesis of hypertensive retinopathy. Knockdown of lncNALT enhances the viability, proliferation, migration, and invasion of human retinal microvascular endothelial cells (RMECs) via the PTEN/PI3K/AKT pathway.
Article
Immunology
Dupiao Zhang, Chen Jin, Tao Han, Jianpeng Chen, Mazhar Ali Raza, Baolong Li, Liang Wang, Hede Yan
Summary: Random flaps are commonly used to cover large skin defects and surgical tissue reconstructions, but their clinical application is limited due to flap necrosis. Sinomenine has been found to enhance flap survival by reducing oxidative stress, promoting autophagy, and angiogenesis. The mechanism involves the PI3K/AKT signaling pathway, antioxidant activity, and eNOS system.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Zheng Xing, Chen Zhao, Chunchen Zhang, Yubo Fan, Haifeng Liu
Summary: The study demonstrated the successful fabrication of bilayer vascular grafts using polycaprolactone and sulfated silk fibroin, along with loading an FDA-approved drug, nicorandil, to enhance biological activity. The NIC-loaded bilayer vascular graft showed promising in vitro performance in increasing endothelial cell proliferation and antioxidation capability, potentially through the activation of the PI3K/AKT/eNOS signaling pathway.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Biochemistry & Molecular Biology
Nadan Lu, Xiaoyi Wang, Weilin Wang, Miaomiao Tang, Jiao Chen, Hongliang You, Dao Wang
Summary: This study investigates the mechanism of microRNA-188-5p (miR-188-5p) mediated drug resistance to doxorubicin (ADM) in acute myeloid leukemia (AML). Differentially expressed miRNAs were screened, and it was found that miR-188-5p was highly expressed in AML cells. Inhibition of miR-188-5p increased the sensitivity of AML/ADM cells to ADM. The study also revealed that TET1 promotes the hydroxymethylation of miR-188-5p promoter, leading to increased miR-188-5p expression. Furthermore, miR-188-5p inhibits PTEN expression, activating the PI3K/AKT signaling pathway and resulting in ADM resistance in AML.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Agriculture, Dairy & Animal Science
Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Min-Kyung Bae, Jung-Hyang Sur
Summary: The frequency of PIK3CA H1047R mutation in canine mammary tumors is 14.3%, leading to dysregulation of downstream molecules Akt2, p-Akt, and PTEN, with the exception of a higher level of PTEN in mutated tumors. No significant correlation was found between PIK3CA H1047R mutation and expression of downstream molecules, suggesting the dysregulation of components in the PI3K/Akt/PTEN pathway is a feature in canine mammary tumors distinct from the mutation.
Article
Medicine, Research & Experimental
Caixia Zhou, Yashu Kuang, Qinyu Li, Yunhao Duan, Xiuxiang Liu, Jinnan Yue, Xiaoli Chen, Jie Liu, Yuzhen Zhang, Lin Zhang
Summary: This study demonstrates that EC-expressing S1pr2 tightly controls post-ischemic angiogenesis and blood flow perfusion recovery. The inhibition of S1pr2 can enhance post-ischemic angiogenesis and improve blood flow in peripheral artery disease, offering a novel therapeutic intervention.
Article
Oncology
Lin Shi, Weiliang Zhu, Yuanyuan Huang, Lin Zhuo, Siyun Wang, Shaobing Chen, Bei Zhang, Bin Ke
Summary: This study found that exosomes released by cancer-associated fibroblasts (CAFs) can promote the progression and chemoresistance of non-small-cell lung cancer (NSCLC). Mechanistically, the exosomes transmit miR-20a to tumor cells, enhancing chemoresistance and proliferation by targeting PTEN.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qin Wu, Jiajun Dong, Xinying Bai, Yuan Jiang, Jinjin Li, Shiqi Fan, Yahong Cheng, Gaofeng Jiang
Summary: This study explores the effects of propionate on neurological deficits, cerebral blood flow, and oxidative stress in diabetic mice. It found that propionate can improve neurological function by stimulating NO production, increasing cerebral microcirculation, suppressing oxidative stress, and reducing neuron loss. The brain-protective function of propionate is related to the PI3K/Akt/eNOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qin Zhu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Ke-Jing Zhang, Yu-Qiong He, Yu Hu
Summary: The study suggests that circSLC8A1 plays a role in breast cancer by regulating the miR-671 and PTEN/PI3k/Akt signaling pathways, leading to inhibition of tumor growth and metastasis.
Review
Cell Biology
Santiago Vidal, Yanis Hichem Bouzaher, Ahmed El Motiam, Rocio Seoane, Carmen Rivas
Summary: The PI3K/AKT pathway, regulated by SUMOylation, plays a crucial role in various physiological processes and may be involved in human diseases.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Tao Wang, Zhiyuan Chen, Hui Chen, Xi Yu, Lei Wang, Xiuheng Liu
Summary: The study aimed to investigate the mechanism by which brusatol regulates the growth of renal cancer cells through the PTEN/PI3K/AKT signaling pathway. The results showed that brusatol significantly inhibited the proliferation, migration, and invasion of A498, ACHN, and OSRC-2 renal cancer cell lines, and increased apoptosis rates.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell Biology
Sakshi Gupta, Mukund Kumar, Soumi Chaudhuri, Arun Kumar
Summary: The PI3K-AKT-MTOR signaling pathway is essential for various cellular functions and has been found to be involved in nuclear processes such as DNA replication, transcription, DNA repair, maintenance of genomic integrity, chromatin architecture, and cell cycle control. Effector molecules of this pathway can translocate to the nucleus and regulate nuclear signaling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Huan Wang, Jian Li, Zheng Wang, Yanfeng Tian, Chunlei Li, Feng Jin, Jia Li, Lanfeng Wang
Summary: The study confirmed the relaxing effect of KYNA generated by the kynurenine pathway on blood vessels, possibly through influencing the PI3K-Akt-eNOS pathway in endothelial cells. Additionally, the reduction of KYNA in obesity may be a critical event in vascular dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Yiming Zhang, Zhaoyi Liu, Jing Lan, Jinliang Wang, Zhiqiang Shen, Guangliang Shi, Shu Li
Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Y. -F. Shi, N. Liu, Y. -X. Li, C. -L. Song, X. -J. Song, Z. Zhao, B. Liu
FREE RADICAL RESEARCH
(2015)
Article
Oncology
Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang, Qian Li
Article
Oncology
Jing Chang, Xin Xue, Chunli Song, Bin Liu, Lihua Gao
MOLECULAR MEDICINE REPORTS
(2017)
Article
Engineering, Biomedical
Jinpeng Wang, Chunli Song, Yanlong Xiao, Bin Liu
JOURNAL OF BIOMATERIALS APPLICATIONS
(2018)
Article
Medical Laboratory Technology
Chun-Li Song, Bin-Li, Hong-Ying Diao, Jiang-Hua Wang, Yong-fei Shi, Yang Lu, Guan Wang, Zi-Yuan Guo, Yang-Xue Li, Jian-Gen Liu, Jin-Peng Wang, Ji-Chang Zhang, Zhuo Zhao, Yi-Hang Liu, Ying Li, Dan Cai, Qian Li
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2016)
Review
Biochemistry & Molecular Biology
Qidong Cao, Ziyuan Guo, Youyou Yan, Jiuping Wu, Chunli Song
Review
Biochemistry & Molecular Biology
Youyou Yan, Dandan Song, Xianjing Song, Chunli Song
Article
Medicine, General & Internal
Yongfeng Shi, Longbo Li, Meijia Liu, Chunli Song, Junduo Wu, Bin Liu
Review
Cell Biology
Qidong Cao, Jiuping Wu, Xiaoli Wang, Chunli Song
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
Ling Hao, Liu Wei-Wu, Hou Xiu-Wei, Chen Xiao-Hui, Xiao Yu, Yan Hui, Song Chun-Li
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
Hongying Diao, Bin Liu, Yongfeng Shi, Chunli Song, Ziyuan Guo, Ning Liu, Xianjing Song, Yang Lu, Xiaoye Lin, Zhuoran Li
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
Article
Medicine, Research & Experimental
Zhuo Zhao, Bin Liu, Bo Li, Chunli Song, Hongying Diao, Ziyuan Guo, Zhibo Li, Jichang Zhang
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Pharmacology & Pharmacy
C. -L. Song, Q. Li, J. -C. Zhang, J. -P. Wang, X. Xue, G. Wang, Y. -F. Shi, H. -Y. Diao, B. Liu
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2016)
Article
Cell Biology
Chun-Li Song, Jin-Peng Wang, Xin Xue, Ning Liu, Xiao-Hao Zhang, Zhuo Zhao, Jian-Gen Liu, Chun-Peng Zhang, Zhe-Hao Piao, Yang Liu, Yi-Bo Yang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)