Review
Immunology
Jia Li, Yuling Huang, Haiyan Sun, Lina Yang
Summary: Mesenchymal stem cells (MSCs) from multiple tissues have the capability of multidirectional differentiation and self-renewal, and their derived exosomes (MSC-Exos) may have a real role to play in treating age-related diseases. The review focuses on the biological characteristics of MSCs and exosomes, their mechanisms in treating age-related diseases, current trials, ongoing clinical trials, and the prospects and challenges for the future use of exosomes in disease treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Denes Toth, Dora Reglodi, Lili Schwieters, Andrea Tamas
Summary: Pituitary adenylate cyclase activating polypeptide (PACAP) is a conserved neuropeptide with diverse anti-aging effects, including anti-apoptotic, anti-inflammatory, and antioxidant action. It has potential as a diagnostic/prognostic biomarker in age-related diseases based on studies showing changes in its levels in different pathological conditions associated with aging. The aim of this review is to summarize and highlight the potential clinical fields for further investigation of PACAP as a diagnostic and/or prognostic biomarker in age-related diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Geriatrics & Gerontology
Michael R. Duggan, Anne Lu, Thomas C. Foster, Mathieu Wimmer, Vinay Parikh
Summary: Aging is a significant risk factor for cognitive decline, but the extent and underlying neurobiology can vary between individuals. Recent developments in analyzing exosomes have improved our understanding of the molecular and cellular mechanisms contributing to cognitive variation in aging. It holds promise for predicting cognitive trajectories and improving functional outcomes for the elderly.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Guadalupe Elizabeth Jimenez Gutierrez, Fabiola V. Borbolla Jimenez, Luis G. Munoz, Yessica Sarai Tapia Guerrero, Nadia Mireya Murillo Melo, Jose Melesio Cristobal-Luna, Norberto Leyva Garcia, Joaquin Cordero-Martinez, Jonathan J. Magana
Summary: Polyamines are short molecules with two or three amine groups that play an important role in age-related diseases. This review provides a new perspective on the involvement of polyamines in cellular and molecular processes related to these diseases, suggesting their potential as novel biomarkers for healthier aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yao Tian, Yuanliangzi Tian, Zhixiao Yuan, Yutian Zeng, Shuai Wang, Xiaolan Fan, Deying Yang, Mingyao Yang
Summary: This review discusses the role of iron metabolism in aging and age-related neurodegenerative diseases, as well as recent developments in using iron chelators as treatment strategies. Understanding iron metabolism is crucial for filling the knowledge gap in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xiaoying Jiang, Ronghui Lei
Summary: Exosomes are membrane-surrounded extracellular vesicles that mediate intercellular communication by delivering bioactive molecules. Long noncoding RNAs (lncRNAs), a class of non-protein-coding RNAs, play important roles in the development of cardiovascular diseases (CVDs). In this article, we review the current studies on exosomal lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, aiming to deepen our understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Chouari Zhor, Lounis Wafaa, Imen Ghzaiel, Khadidja Kessas, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Norbert Latruffe, Olfa Masmoudi-Kouki, Adil El Midaoui, Dominique Vervandier-Fasseur, Mohamed Hammami, Gerard Lizard, Anne Vejux, Omar Kharoubi
Summary: Aging leads to the deterioration of cellular functions and increases the risk of age-related diseases. Cardiovascular diseases, some neurological disorders, and cancers are among the diseases that affect lifespan and are associated with accumulated cellular damage and reduced stress response pathways. Inflammation and oxidative stress, key factors in the aging process, result from these processes. Edible plants have gained interest for their potential therapeutic effects in preventing age-related diseases. The beneficial effects of these foods are attributed, in part, to their high concentration of bioactive phenolic compounds, particularly antioxidants, which are associated with slower aging. Human dietary intervention studies strongly support the protective role of polyphenol supplementation in preventing age-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Food Science & Technology
Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli, Tewin Tencomnao
Summary: The translation section discusses the impact of age-related diseases on societal and healthcare expenditure, as well as the importance of anti-aging strategies. It then lists the various protective effects of astaxanthin, covering multiple organs and diseases, including neurodegenerative diseases, bone-related diseases, cancers, cardiovascular disorders, diabetes-associated complications, eye disorders, gastric disorders, kidney disorders, liver diseases, pulmonary disorders, muscle disorders, and skin diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Ivona Maria Tudorancea, Mitica Ciorpac, Gabriela Dumitrita Stanciu, Catalin Caratasu, Alina Sacarescu, Bogdan Ignat, Alexandra Burlui, Elena Rezus, Ioana Creanga, Teodora Alexa-Stratulat, Ionut Tudorancea, Bogdan Ionel Tamba
Summary: The endocannabinoid system (ECS) plays a significant role in regulating various aspects of mammalian physiology and has potential therapeutic effects in age-related diseases. This comprehensive review explores the complex interaction between the cannabinoid system (CS) and neurodegenerative, oncological, skeletal, and cardiovascular disorders, highlighting the potential of cannabinoids to ameliorate these conditions. The role of the ECS in improving aging-associated immune system dysregulation is also discussed.
Review
Cell Biology
Zhidan Zhang, Yuling Huang, AYao Guo, Lina Yang
Summary: Circular RNAs (circRNAs) are a class of single-stranded endogenous closed circular RNAs, lacking poly(A) tail and cap structure, and connected by covalent bonds. They have diverse functions in transcriptional control and protein translation, and play important roles in cell senescence, individual aging, and age-related diseases. This review summarizes recent studies on circRNAs, including biosynthesis mechanisms, classification, expression, biomedical functions, associations with aging and age-related diseases, and potential clinical applications. It provides a theoretical basis for exploring the molecular biological mechanisms of aging, using circRNA as a therapeutic target to delay aging, and finding therapeutic strategies for age-related diseases.
AGEING RESEARCH REVIEWS
(2023)
Review
Geriatrics & Gerontology
Lina Sun, Lingyan Wang, Kaisy Xinhong Ye, Shoushi Wang, Rui Zhang, Zhaodong Juan, Lei Feng, Su Min
Summary: The worldwide aging population brings burdens to patients, families, and society due to the increased risk of chronic diseases. The vascular system's aging is closely related to the development of age-related diseases. Endothelial glycocalyx, a layer of proteoglycan polymers on blood vessel surfaces, plays a crucial role in maintaining vascular homeostasis and protecting organ functions. The loss of endothelial glycocalyx through aging can be alleviated by repairing it, potentially serving as a therapeutic target for aging and age-related diseases and promoting healthy aging and longevity.
Article
Environmental Sciences
Haktan Bagis Erdem, Taha Bahsi, Mehmet Ali Ergun
Summary: Telomeres are specialized non-coding DNA repeat sequences that play a crucial role in maintaining genome integrity. Short telomeres have been associated with age-related diseases, but factors influencing telomere length are not well understood. Future research is expected to lead to clinical applications of telomere length analysis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Geriatrics & Gerontology
Haoxiang Xiao, Yuqiao Xie, Kaiwen Xi, Jinyi Xie, Mingyue Liu, Yangming Zhang, Zishuo Cheng, Wenting Wang, Baolin Guo, Shengxi Wu
Summary: Aging leads to functional declines and impairments in numerous physiological processes, resulting in fibrosis and neurodegenerative diseases (NDs). Mitochondrial sirtuins (SIRT3-5) play a crucial role in regulating mitochondrial function and have been shown to provide protection against fibrosis and NDs. SIRT3-5 are emerging as promising therapeutic targets for antifibrotic therapies and the treatment of NDs. This review highlights recent advances in understanding the role of SIRT3-5 in fibrosis and NDs and discusses their potential as therapeutic targets.
Review
Geriatrics & Gerontology
Ya Yuan, Jiamei Li, Zhi He, Xiaolan Fan, Xueping Mao, Mingyao Yang, Deying Yang
Summary: tRNA-derived fragments (tRFs) are non-coding RNAs produced via tRNA cleavage, with lengths of 14 to 50 nucleotides, originating from precursor tRNAs or mature tRNAs. They are not randomly generated but through specific mechanisms, detectable in model organisms of different ages and associated with age-related diseases in humans. This literature review summarizes the origin, classification, and regulatory mechanisms of tRFs, as well as describing available databases and research techniques, laying the groundwork for exploring tRFs as biomarkers for the diagnosis and treatment of aging and age-related diseases.
Review
Nutrition & Dietetics
Grazia Maria Liuzzi, Tania Petraglia, Tiziana Latronico, Aniello Crescenzi, Rocco Rossano
Summary: The increase in life expectancy has led to the emergence of age-related diseases, including neurodegenerative diseases. Oxidative stress, caused by an imbalance of reactive oxygen species, contributes to these diseases. Dietary supplementation with antioxidant-containing foods, such as edible mushrooms, can enhance antioxidant defenses and prevent age-related neurological diseases.
Article
Biochemistry & Molecular Biology
Y. -F. Shi, N. Liu, Y. -X. Li, C. -L. Song, X. -J. Song, Z. Zhao, B. Liu
FREE RADICAL RESEARCH
(2015)
Article
Oncology
Chun-Li Song, Bin Liu, Yong-Feng Shi, Ning Liu, You-You Yan, Ji-Chang Zhang, Xin Xue, Jin-Peng Wang, Zhuo Zhao, Jian-Gen Liu, Yang-Xue Li, Xiao-Hao Zhang, Jun-Duo Wu
Article
Oncology
Chun-Li Song, Bin Liu, Hong-Ying Diao, Yong-Feng Shi, Ji-Chang Zhang, Yang-Xue Li, Ning Liu, Yun-Peng Yu, Guan Wang, Jin-Peng Wang, Qian Li
Article
Oncology
Jing Chang, Xin Xue, Chunli Song, Bin Liu, Lihua Gao
MOLECULAR MEDICINE REPORTS
(2017)
Article
Engineering, Biomedical
Jinpeng Wang, Chunli Song, Yanlong Xiao, Bin Liu
JOURNAL OF BIOMATERIALS APPLICATIONS
(2018)
Article
Medical Laboratory Technology
Chun-Li Song, Bin-Li, Hong-Ying Diao, Jiang-Hua Wang, Yong-fei Shi, Yang Lu, Guan Wang, Zi-Yuan Guo, Yang-Xue Li, Jian-Gen Liu, Jin-Peng Wang, Ji-Chang Zhang, Zhuo Zhao, Yi-Hang Liu, Ying Li, Dan Cai, Qian Li
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2016)
Review
Biochemistry & Molecular Biology
Youyou Yan, Dandan Song, Xianjing Song, Chunli Song
Article
Medicine, General & Internal
Yongfeng Shi, Longbo Li, Meijia Liu, Chunli Song, Junduo Wu, Bin Liu
Review
Cell Biology
Qidong Cao, Jiuping Wu, Xiaoli Wang, Chunli Song
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
Ling Hao, Liu Wei-Wu, Hou Xiu-Wei, Chen Xiao-Hui, Xiao Yu, Yan Hui, Song Chun-Li
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
Hongying Diao, Bin Liu, Yongfeng Shi, Chunli Song, Ziyuan Guo, Ning Liu, Xianjing Song, Yang Lu, Xiaoye Lin, Zhuoran Li
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
Article
Medicine, Research & Experimental
Zhuo Zhao, Bin Liu, Bo Li, Chunli Song, Hongying Diao, Ziyuan Guo, Zhibo Li, Jichang Zhang
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Pharmacology & Pharmacy
C. -L. Song, Q. Li, J. -C. Zhang, J. -P. Wang, X. Xue, G. Wang, Y. -F. Shi, H. -Y. Diao, B. Liu
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2016)
Article
Cell Biology
Chun-Li Song, Jin-Peng Wang, Xin Xue, Ning Liu, Xiao-Hao Zhang, Zhuo Zhao, Jian-Gen Liu, Chun-Peng Zhang, Zhe-Hao Piao, Yang Liu, Yi-Bo Yang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)
