Heavy lessons in protein allostery

Allosteric inhibition of antiapoptotic MCL-1

(2016) Susan Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric inhibition of antiapoptotic MCL-1

(2016) Susan Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The $2.6 Billion Pill — Methodologic and Policy Considerations

(2015) Jerry Avorn   NEW ENGLAND JOURNAL OF MEDICINE

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Allosteric targeting of receptor tyrosine kinases

(2014) Frederik De Smet et al.   NATURE BIOTECHNOLOGY

High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design

(2014) Gaohua Liu et al.   PLoS One

Unraveling structural mechanisms of allosteric drug action

(2014) Ruth Nussinov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

ClpP: A structurally dynamic protease regulated by AAA+ proteins

(2012) John A. Alexopoulos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS