Investigational Notch and Hedgehog inhibitors – therapies for cardiovascular disease

Therapeutic potential of plasma membrane-derived microparticles

(2014) Tarek Benameur et al.   Pharmacological Reports

Soluble Jagged-1 Inhibits Neointima Formation by Attenuating Notch-Herp2 Signaling

(2011) Vincenza Caolo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Jagged1 in Arterial Lesions After Vascular Injury

(2011) Xiaojing Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival

(2011) Shaunta Guha et al.   BASIC RESEARCH IN CARDIOLOGY

Dysfunctional transforming growth factor-β signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma

(2011) Jonathan Mendelson et al.   CANCER

γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer’s Disease

(2011) Kohzo Nakayama et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hedgehog signaling in skin cancers

(2011) Chengxin Li et al.   CELLULAR SIGNALLING

Mechanism and Significance of cis-Inhibition in Notch Signalling

(2011) David del Álamo et al.   CURRENT BIOLOGY

Hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases

(2011) Monica Dentice   EXPERT OPINION ON THERAPEUTIC TARGETS

Notch3 Is Essential for Regulation of the Renal Vascular Tone

(2011) Nada Boulos et al.   HYPERTENSION

The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells

(2011) Joshua M. Boucher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

(2011) Zhenyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the Hedgehog Pathway: The development of Cyclopamine and the Development of Anti-Cancer Drugs Targeting the Hedgehog Pathway

(2011) A. Gould et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Companies race to develop first Hedgehog inhibitor cancer drug

(2011) Elie Dolgin   NATURE MEDICINE

Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

(2011) Mattias Kalén et al.   PLoS One

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease

(2011) J. F. Arboleda-Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog morphogen: from secretion to reception

(2011) Armel Gallet   TRENDS IN CELL BIOLOGY

Sonic Hedgehog Signaling Induces Vascular Smooth Muscle Cell Proliferation via Induction of the G 1 Cyclin-Retinoblastoma Axis

(2010) Fenghe Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pathogenesis of CADASIL

(2010) Anne Joutel   BIOESSAYS

Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice

(2010) Lan Cao et al.   BIOMATERIALS

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia

(2010) Maddalena Paganin et al.   BLOOD REVIEWS

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

(2010) Tom Donnem et al.   CANCER

Assessing the efficacy of the Hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer

(2010) Lois W. Brüggemann et al.   CANCER BIOLOGY & THERAPY

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

(2010) Leandro C. Cerchietti et al.   CANCER CELL

Breast Cancer Stem Cells: Something Out of Notching?

(2010) H. Harrison et al.   CANCER RESEARCH

Hedgehog signaling and therapeutics in pancreatic cancer

(2010) F. C. Kelleher   CARCINOGENESIS

Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

(2010) Stefan Peukert et al.   ChemMedChem

Inhibition of Delta-Like-4–Mediated Signaling Impairs Reparative Angiogenesis After Ischemia

(2010) Ayman Al Haj Zen et al.   CIRCULATION RESEARCH

Weary of the Stress

(2010) Edward E. Morrisey   CIRCULATION RESEARCH

Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand

(2010) Il-Man Kim et al.   CIRCULATION RESEARCH

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

New developments in the discovery of small molecule Hedgehog pathway antagonists

(2010) Martin R Tremblay et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Notch signaling pathway: Molecular basis of cell context dependency

(2010) Ralf Schwanbeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Targeting Notch signaling in pancreatic cancer

(2010) Elodie Ristorcelli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer stem cells: problems for therapy?

(2010) Malcolm R Alison et al.   JOURNAL OF PATHOLOGY

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Mapping the face in the somatosensory brainstem

(2010) Reha S. Erzurumlu et al.   NATURE REVIEWS NEUROSCIENCE

Microparticles harboring sonic hedgehog

(2010) Raffaella Soleti et al.   Cell Adhesion & Migration

17β-Estradiol inhibits chondrogenesis in the skull development of zebrafish embryos

(2009) Shigeko Fushimi et al.   AQUATIC TOXICOLOGY

Sonic Hedgehog Induces Notch Target Gene Expression in Vascular Smooth Muscle Cells via VEGF-A

(2009) David Morrow et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

(2009) J Tammam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Preclinical Profile of a Potent  -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

(2009) L. Luistro et al.   CANCER RESEARCH

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Smooth Muscle Notch1 Mediates Neointimal Formation After Vascular Injury

(2009) Yuxin Li et al.   CIRCULATION

Shared Circuitry

(2009) Kory J. Lavine et al.   CIRCULATION RESEARCH

Arterial–Venous Specification During Development

(2009) Matthew R. Swift et al.   CIRCULATION RESEARCH

A Notch updated

(2009) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

Hypoxia-inducible factors in stem cells and cancer

(2009) Jolly Mazumdar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway

(2009) J. H. Lee et al.   MOLECULAR CANCER RESEARCH

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch and Vascular Smooth Muscle Cell Phenotype

(2008) David Morrow et al.   CIRCULATION RESEARCH

Stabilized  -Catenin Functions through TCF/LEF Proteins and the Notch/RBP-J  Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells

(2008) T. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells

(2008) J. N. Passman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA