Divergent synthesis and identification of the cellular targets of deoxyelephantopins

Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine

(2015) Ting Dong et al.   Nature Communications

Efficient Oxidation and Destabilization of Zn(Cys)4Zinc Fingers by Singlet Oxygen

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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Photochemical formation of intricarene

(2014) Desiree Stichnoth et al.   Nature Communications

Pd-catalyzed diastereoselective allylation of aldehydes with 3-bromomethyl-5H-furan-2-one: stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones with a syn configuration

(2013) Fuhai Zhang et al.   CHEMICAL COMMUNICATIONS

Sesquiterpenoids Lactones: Benefits to Plants and People

(2013) Martin Chadwick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate

(2013) Jing Li et al.   Nature Chemistry

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Irreversible kinase inhibitors gain traction

(2013) Katharine Sanderson   NATURE REVIEWS DRUG DISCOVERY

α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation

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A Modular and Scalable One-Pot Synthesis of Polysubstituted Furans

(2012) Jeremy Fournier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Asymmetric Allylic Alkylation of Cyclic Dienol Carbonates: Efficient Route to Enantioenriched γ-Butenolides Bearing an All-Carbon α-Quaternary Stereogenic Center

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Asymmetric catalysts for stereocontrolled olefin metathesis reactions

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Cystathionine Protects against Endoplasmic Reticulum Stress-induced Lipid Accumulation, Tissue Injury, and Apoptotic Cell Death

(2012) Kenneth N. Maclean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Electrophilic natural products and their biological targets

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Nucleophilic reactivity of Zinc-bound thiolates: subtle interplay between coordination set and conformational flexibility

(2012) Manon Isaac et al.   Chemical Science

Biology-Oriented Synthesis

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Perspectives on Sesquiterpene Lactones in Inflammation and Cancer

(2011) Irmgard Merfort   CURRENT DRUG TARGETS

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Stereoselective Synthesis of β-(Hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones

(2011) David M. Hodgson et al.   ORGANIC LETTERS

Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice

(2010) Chi-Chang Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

The Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches

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Cystatin B As a Tissue and Urinary Biomarker of Bladder Cancer Recurrence and Disease Progression

(2009) A. S. Feldman et al.   CLINICAL CANCER RESEARCH

Covalent Modifiers: An Orthogonal Approach to Drug Design

(2009) Michele H. Potashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential Proteomic Profiling Identifies Novel Molecular Targets of Paclitaxel and Phytoagent Deoxyelephantopin against Mammary Adenocarcinoma Cells

(2009) Wai-Leng Lee et al.   JOURNAL OF PROTEOME RESEARCH

Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of Enol Carbonates

(2009) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular diversity by design

(2009) Stuart L. Schreiber   NATURE

Synthesis at the molecular frontier

(2009) Paul A. Wender et al.   NATURE

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Mechanistically Inspired Catalysts for Enantioselective Desymmetrizations by Olefin Metathesis

(2008) Pierre-André Fournier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Naturally diverse: highlights in versatile synthetic methods enabling target- and diversity-oriented synthesis

(2008) Jared T. Shaw   NATURAL PRODUCT REPORTS

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARγ

(2007) Gang Zou et al.   BIOCHEMICAL PHARMACOLOGY