Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair

(2014) Julian Stingele et al.   CELL

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

(2014) Davor Lessel et al.   NATURE GENETICS

Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association

(2014) Prabha Sarangi et al.   NUCLEIC ACIDS RESEARCH

Spartan deficiency causes genomic instability and progeroid phenotypes

(2014) Reeja S. Maskey et al.   Nature Communications

SIM-dependent enhancement of substrate-specific SUMOylation by a ubiquitin ligasein vitro

(2013) Joanne L. Parker et al.   BIOCHEMICAL JOURNAL

SUMO-targeted ubiquitin ligases

(2013) Annie M. Sriramachandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of proteolysis by human deubiquitinating enzymes

(2013) Ziad M. Eletr et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy and genomic integrity

(2013) A T Vessoni et al.   CELL DEATH AND DIFFERENTIATION

A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases

(2013) Mar López-Pelegrín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction

(2013) Steven Bergink et al.   NATURE CELL BIOLOGY

Role of p97/VCP (Cdc48) in genome stability

(2013) Bruno Vaz et al.   Frontiers in Genetics

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Dual Recruitment of Cdc48 (p97)-Ufd1-Npl4 Ubiquitin-selective Segregase by Small Ubiquitin-like Modifier Protein (SUMO) and Ubiquitin in SUMO-targeted Ubiquitin Ligase-mediated Genome Stability Functions

(2012) Minghua Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

(2012) Emily J Davis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

(2012) Anna Mosbech et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of error-prone translesion synthesis by Spartan/C1orf124

(2012) Myoung Shin Kim et al.   NUCLEIC ACIDS RESEARCH

DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase

(2012) F. Dotiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A General Chemical Ligation Approach Towards Isopeptide-Linked Ubiquitin and Ubiquitin-Like Assay Reagents

(2011) Paul P. Geurink et al.   CHEMBIOCHEM

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

The General Definition of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM) Delineates a New Family of p97 Cofactors

(2011) Christopher Stapf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM)

(2011) Petra Hänzelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

The SUMO Isopeptidase Ulp2p Is Required to Prevent Recombination-Induced Chromosome Segregation Lethality following DNA Replication Stress

(2011) Ming-Ta Lee et al.   PLoS Genetics

SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1–Mediated DNA Damage and Genome Instability

(2011) Johanna Heideker et al.   PLoS Genetics

Metallo-aminopeptidase inhibitors

(2010) Artur Mucha et al.   BIOCHIMIE

Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy

(2010) Batool Ossareh-Nazari et al.   EMBO REPORTS

Genetic Evidence That Polysumoylation Bypasses the Need for a SUMO-Targeted Ub Ligase

(2010) J. R. Mullen et al.   GENETICS

SUMOylation modulates the function of Aurora-B kinase

(2010) G. Fernandez-Miranda et al.   JOURNAL OF CELL SCIENCE

Wss1 Is a SUMO-Dependent Isopeptidase That Interacts Genetically with the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase

(2010) J. R. Mullen et al.   MOLECULAR AND CELLULAR BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

A Role for Non-Covalent SUMO Interaction Motifs in Pc2/CBX4 E3 Activity

(2010) Jacqueline C. Merrill et al.   PLoS One

Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells

(2009) Toshiaki Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic Networks

(2009) Taras Makhnevych et al.   MOLECULAR CELL

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Insights into adaptor binding to the AAA protein p97

(2008) Heidi O. Yeung et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TheSaccharomyces cerevisiaeWss1 protein is only present in mother cells

(2008) G. Paul H. van Heusden et al.   FEMS MICROBIOLOGY LETTERS

DOA1/UFD3 Plays a Role in Sorting Ubiquitinated Membrane Proteins into Multivesicular Bodies

(2008) Jihui Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

(2008) S. J. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A SIM-ultaneous role for SUMO and ubiquitin

(2008) J. Jefferson P. Perry et al.   TRENDS IN BIOCHEMICAL SCIENCES