Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing

(2016) Andrew L. Paek et al.   CELL

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer

(2016) Piero Dalerba et al.   NEW ENGLAND JOURNAL OF MEDICINE

Obesity promotes colonic stem cell expansion during cancer initiation

(2015) V. DeClercq et al.   CANCER LETTERS

Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer

(2015) L. A. Davidson et al.   CANCER RESEARCH

Homeostatic responses of colonic LGR5+stem cells following acutein vivoexposure to a genotoxic carcinogen

(2015) Eunjoo Kim et al.   CARCINOGENESIS

Substantial contribution of extrinsic risk factors to cancer development

(2015) Song Wu et al.   NATURE

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Evaluation of Cancer Stem Cell Markers CD133, CD44, CD24: Association with AKT Isoforms and Radiation Resistance in Colon Cancer Cells

(2014) Sara Häggblad Sahlberg et al.   PLoS One

BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs

(2014) Brian Leibowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus

(2014) Jurian Schuijers et al.   Stem Cell Reports

Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

(2014) Ning Li et al.   Stem Cell Reports

Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice

(2013) Rafat A Siddiqui et al.   BMC CANCER

LGR5 positivity defines stem-like cells in colorectal cancer

(2013) Daniela Hirsch et al.   CARCINOGENESIS

Pharmacological modulation of beta-catenin and its applications in cancer therapy

(2013) Ravi Thakur et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice

(2012) Michael E. Rothenberg et al.   GASTROENTEROLOGY

Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant

(2012) Guoqiang Hua et al.   GASTROENTEROLOGY

Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer

(2012) Manuel Valladares-Ayerbes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis

(2012) Raluca Dumitru et al.   MOLECULAR CELL

Curcumin Inhibits Proliferation and Induces Apoptosis of Human Colorectal Cancer Cells by Activating the Mitochondria Apoptotic Pathway

(2012) Li-da Guo et al.   PHYTOTHERAPY RESEARCH

Alteration of EGFR Spatiotemporal Dynamics Suppresses Signal Transduction

(2012) Harmony F. Turk et al.   PLoS One

A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

(2011) Jeffrey D Altenburg et al.   BMC CANCER

Dietary fish oil and curcumin combine to modulate colonic cytokinetics and gene expression in dextran sodium sulphate-treated mice

(2011) Qian Jia et al.   BRITISH JOURNAL OF NUTRITION

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

(2011) R. E. Carroll et al.   Cancer Prevention Research

Curcumin Inhibition of the Functional Interaction between Integrin  6 4 and the Epidermal Growth Factor Receptor

(2011) Y. H. Soung et al.   MOLECULAR CANCER THERAPEUTICS

Single-cell dissection of transcriptional heterogeneity in human colon tumors

(2011) Piero Dalerba et al.   NATURE BIOTECHNOLOGY

Lipid Rafts and Fas/CD95 Signaling in Cancer Chemotherapy

(2011) Consuelo Gajate et al.   Recent Patents on Anti-Cancer Drug Discovery

Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis

(2010) N. J. West et al.   GUT

Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid

(2009) Constance Lay Lay Saw et al.   BIOCHEMICAL PHARMACOLOGY

Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal Adenomas

(2009) J. A. Zell et al.   Cancer Prevention Research

Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis

(2009) Gang Xu et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary Curcumin and Limonin Suppress CD4+ T-Cell Proliferation and Interleukin-2 Production in Mice

(2009) Wooki Kim et al.   JOURNAL OF NUTRITION

β-catenin Expression is Altered in Dysplastic and Nondysplastic Aberrant Crypt Foci of Human Colon

(2009) Biantao Mi et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

(2008) Frank L. Meyskens et al.   Cancer Prevention Research

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids

(2008) Malisetty V. Swamy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Serrated Adenoma of the Colorectum Undergoes a Proliferation versus Differentiation Process: New Conceptual Interpretation of Morphogenesis

(2008) Yu-Fei Jiao et al.   ONCOLOGY

Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers

(2008) Worrawit Wanitsuwan et al.   WORLD JOURNAL OF GASTROENTEROLOGY