Prediction of disease–gene–drug relationships following a differential network analysis

The Comparative Toxicogenomics Database's 10th year anniversary: update 2015

(2014) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an Application to Colorectal Adenocarcinoma

(2014) Feng-Hsiang Chung et al.   PLoS One

Identifying regulatory mechanisms underlying tumorigenesis using locus expression signature analysis

(2014) E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: A Population Shift View of Cellular Reprogramming

(2014) Antonio del Sol et al.   STEM CELLS

Detecting cellular reprogramming determinants by differential stability analysis of gene regulatory networks

(2013) Isaac Crespo et al.   BMC Systems Biology

17β-Estradiol Protects Against the Progression of Hypertension During Adulthood in a Mouse Model of Systemic Lupus Erythematosus

(2013) Emily L. Gilbert et al.   HYPERTENSION

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding

(2013) M. Iskar et al.   Molecular Systems Biology

Integrative approaches for finding modular structure in biological networks

(2013) Koyel Mitra et al.   NATURE REVIEWS GENETICS

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

A general strategy for cellular reprogramming: The importance of transcription factor cross-repression

(2013) Isaac Crespo et al.   STEM CELLS

Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs

(2013) Ioannis N. Melas et al.   PLoS Computational Biology

CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms

(2012) Camille Terfve et al.   BMC Systems Biology

IRF7, a functional factor associates with systemic lupus erythematosus

(2012) Wang-Dong Xu et al.   CYTOKINE

Differential network biology

(2012) Trey Ideker et al.   Molecular Systems Biology

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Predicting missing expression values in gene regulatory networks using a discrete logic modeling optimization guided by network stable states

(2012) Isaac Crespo et al.   NUCLEIC ACIDS RESEARCH

Ausência de associação entre o genótipo CC do polimorfismo rs7903146 no gene TCF7L2 e artrite reumatoide

(2012) Licia Maria Henrique da Mota et al.   Revista Brasileira De Reumatologia

jMetal: A Java framework for multi-objective optimization

(2011) Juan J. Durillo et al.   ADVANCES IN ENGINEERING SOFTWARE

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

(2011) Gustavo Tiscornia et al.   NATURE MEDICINE

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diseases as network perturbations

(2010) Antonio del Sol et al.   CURRENT OPINION IN BIOTECHNOLOGY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding gene circuits at cell-fate branch points for rational cell reprogramming

(2010) Joseph X. Zhou et al.   TRENDS IN GENETICS

Identifying Network of Drug Mode of Action by Gene Expression Profiling

(2009) Francesco Iorio et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus

(2009) J Li et al.   LUPUS

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective

(2009) Sui Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

From minimal signed circuits to the dynamics of Boolean regulatory networks

(2008) E. Remy et al.   BIOINFORMATICS

Synchronous versus asynchronous modeling of gene regulatory networks

(2008) A. Garg et al.   BIOINFORMATICS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Cobalt chloride attenuates hypobaric hypoxia induced vascular leakage in rat brain: Molecular mechanisms of action of cobalt chloride☆

(2008) S KALPANA et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY