TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the E -TCL1 mouse model

(2015) M. D. Blunt et al.   BLOOD

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

(2015) F. McClanahan et al.   BLOOD

Two types of BCR interactions are positively selected during leukemia development in the E -TCL1 transgenic mouse model of CLL

(2015) S. Iacovelli et al.   BLOOD

Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the E -TCL1 CLL mouse model

(2015) F. McClanahan et al.   BLOOD

Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model

(2015) Franz J. Gassner et al.   BRITISH JOURNAL OF HAEMATOLOGY

Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification

(2015) G D te Raa et al.   Cell Death & Disease

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

(2015) G S Choudhary et al.   Cell Death & Disease

miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model

(2015) Antonella Bresin et al.   Oncotarget

Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy

(2014) G. Simonetti et al.   BLOOD

OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells

(2014) T.-M. Liu et al.   BLOOD

Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia

(2014) W. Fiskus et al.   CANCER RESEARCH

Role of miR-15/16 in CLL

(2014) Y Pekarsky et al.   CELL DEATH AND DIFFERENTIATION

microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters

(2014) M. Negrini et al.   CLINICAL CANCER RESEARCH

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

(2014) T Motiwala et al.   LEUKEMIA

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(2014) Amit Mittal et al.   MOLECULAR MEDICINE

Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia

(2014) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation

(2014) K. Heinig et al.   Cancer Discovery

Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model

(2013) V. Lascano et al.   BLOOD

CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

(2013) O. Fedorchenko et al.   BLOOD

Accelerated progression of chronic lymphocytic leukemia in E -TCL1 mice expressing catalytically inactive RAG1

(2013) V. K. Nganga et al.   BLOOD

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

(2013) J. A. Woyach et al.   BLOOD

Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia

(2013) E. ten Hacken et al.   BLOOD

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

(2013) N. Yaktapour et al.   BLOOD

Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53 −/− mouse model and primary human leukemia cells

(2013) J Liu et al.   LEUKEMIA

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Analysis of Tcl1 Using Tcl1-Deficient Mouse Embryonic Stem Cells

(2013) Tatsushi Miyazaki et al.   PLoS One

ROR1 can interact with TCL1 and enhance leukemogenesis in E -TCL1 transgenic mice

(2013) G. F. Widhopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling

(2013) S.-S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cell receptor signaling in chronic lymphocytic leukemia

(2013) Jan A. Burger et al.   TRENDS IN IMMUNOLOGY

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor

(2012) N. Reinart et al.   BLOOD

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice

(2012) C. L. Kriss et al.   BLOOD

Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function

(2012) D J DiLillo et al.   LEUKEMIA

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

(2012) Marcus Dühren-von Minden et al.   NATURE

Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)

(2012) A. Palamarchuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia

(2011) T. Motiwala et al.   BLOOD

Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models

(2011) M. T. S. Bertilaccio et al.   BLOOD

Tcl1 interacts with Atm and enhances NF- B activation in hematologic malignancies

(2011) E. Gaudio et al.   BLOOD

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

(2011) S. Ponader et al.   BLOOD

miR-181b is a biomarker of disease progression in chronic lymphocytic leukemia

(2011) R. Visone et al.   BLOOD

B-cell receptor signaling in chronic lymphocytic leukemia

(2011) F. K. Stevenson et al.   BLOOD

Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia

(2011) P. C. Amrein et al.   CLINICAL CANCER RESEARCH

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL

(2011) J Piñón Hofbauer et al.   LEUKEMIA

miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes

(2011) Yi-Bing Ouyang et al.   MITOCHONDRION

HS1 has a central role in the trafficking and homing of leukemic B cells

(2010) C. Scielzo et al.   BLOOD

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the E - TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

(2010) M. Suljagic et al.   BLOOD

Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL

(2010) S.-S. Chen et al.   BLOOD

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia

(2010) D. Asslaber et al.   BLOOD

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application

(2010) S. Patrick Nana-Sinkam et al.   CANCER GENETICS AND CYTOGENETICS

Epigenetic alterations in a murine model for chronic lymphocytic leukemia

(2010) Shih-Shih Chen et al.   CELL CYCLE

CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation

(2010) A Efanov et al.   LEUKEMIA

The Novel Deacetylase Inhibitor AR-42 Demonstrates Pre-Clinical Activity in B-Cell Malignancies In Vitro and In Vivo

(2010) David M. Lucas et al.   PLoS One

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia

(2009) M. Herling et al.   BLOOD

Karyotype-specific microRNA signature in chronic lymphocytic leukemia

(2009) R. Visone et al.   BLOOD

PKC  is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKC  as a therapeutic target in chronic lymphocytic leukemia

(2009) C. Holler et al.   BLOOD

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

(2009) J. A. Burger et al.   BLOOD

Chronic lymphocytic leukemia of E -TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression

(2009) T. Enzler et al.   BLOOD

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

(2009) R I Aqeilan et al.   CELL DEATH AND DIFFERENTIATION

Tumoricidal Effects of Activated Macrophages in a Mouse Model of Chronic Lymphocytic Leukemia

(2009) Q.-L. Wu et al.   JOURNAL OF IMMUNOLOGY

The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen–telogen transition and affects stem-cell marker CD34 expression

(2009) G Ragone et al.   ONCOGENE

Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia

(2009) S.-S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E -TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction

(2009) G. Gorgun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-15a and miR-16-1 cluster functions in human leukemia

(2008) George A. Calin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL

(2008) Y. Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD