Article
Immunology
Yeqin Sha, Rui Jiang, Yi Miao, Shuchao Qin, Wei Wu, Yi Xia, Li Wang, Lei Fan, Hui Jin, Wei Xu, Jianyong Li, Huayuan Zhu
Summary: This study identified differentially expressed pyroptosis-related genes (PRGs) between CLL and normal B cells, and constructed a risk model with three PRG signatures that showed high efficacy in predicting overall survival and time to first treatment in CLL. Functional and pathway analysis further revealed dysregulated immune and inflammatory responses in the high-risk group, as well as decreased immune cell infiltration and activity of immune-related pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Gian Mario Sambuceti, Franco Fais, Daniela de Totero
Summary: Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. In this disease, interactions between CLL cells and bone tissue components may lead to alterations in bone homeostasis. Recent research suggests that disruption of the endosteal niche by the expansion of a leukemic B cell clone is worth further investigation for potential therapeutic approaches.
Review
Oncology
Elisavet Vlachonikola, Kostas Stamatopoulos, Anastasia Chatzidimitriou
Summary: The treatment of chronic lymphocytic leukemia (CLL) is continuously evolving, with immunotherapy emerging as a therapeutic option to boost immune responses against tumors. However, not all patients benefit from this approach, partly due to dysfunctional T cells in CLL. The tumor microenvironment (TME) is also crucial in impacting immune responses and tumor growth, highlighting the importance of understanding T cell defects and finding ways to overcome them for effective immunotherapy in CLL.
Review
Oncology
Pablo Oppezzo, Marcelo Navarrete, Nicholas Chiorazzi
Summary: This review article discusses the dual role of the enzyme activation-induced cytidine deaminase (AID) in adaptive immunity and B-cell malignancies, emphasizing its pathological effects as a causative factor in leukemia and lymphomas. It summarizes the expression and function of AID in normal B lymphocytes, evaluates potential causes for AID expression in leukemic cells, and discusses its role in lymphomagenesis based on recent genomic landscape analyses of leukemia and lymphomas. The review also touches upon the correlation between AID off-target mutations and tumor-gene drivers in these cancers, and how these mutations could impact disease progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Zhenghao Chen, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke Schomakers, Michel van Weeghel, Dean J. Bryant, Jaco A. C. van Bruggen, Fleur S. Peters, Jeffrey C. Rathmell, Gerritje J. W. van der Windt, Arnon P. Kater, Graham Packham, Eric Eldering
Summary: Through metabolomic and transcriptomic analysis of chronic lymphocytic leukemia (CLL) cells, this study reveals the metabolic differences between cells in the lymph nodes and peripheral blood. The CD40 and BCR signaling pathways play different roles in regulating cell metabolism, which may be related to therapeutic response. Additionally, the significant use of amino acids as fuel for the tricarboxylic acid cycle suggests new therapeutic vulnerabilities.
Review
Oncology
Laura Patrussi, Nagaja Capitani, Cosima T. Baldari
Summary: IL-9, a soluble factor secreted by immune cells, has been found in several tumor niches, with dual roles in promoting or counteracting tumor development depending on the specific type of cancer. Recent studies implicate IL-9 in chronic lymphocytic leukemia pathogenesis, yet the molecular mechanisms remain unclear.
Review
Immunology
Yanyan Liu, Yongping Song, Qingsong Yin
Summary: This review summarizes the effects of ibrutinib on the tumor microenvironment and cellular immunity in patients with CLL, particularly focusing on the behavior and function of T cells. The potential mechanisms of ibrutinib are explored, providing a basis for the clinical benefits of long-term ibrutinib treatment and combined therapy based on T-cell-based immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Elisavet Vlachonikola, Kostas Stamatopoulos, Anastasia Chatzidimitriou
Summary: Chronic lymphocytic leukemia remains incurable despite recent progress in management, highlighting the importance of further investigating the underlying pathophysiology. The interactions between malignant CLL cells and the tumor microenvironment play a crucial role in disease progression, with T cell abnormalities and potential therapeutic targets being a key focus in enhancing targeted cytotoxic activity against the malignant clone.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Marta Sureda-Gomez, Patricia Balsas, Marta-Leonor Rodriguez, Ferran Nadeu, Anna De Bolos, Alvaro Eguileor, Marta Kulis, Giancarlo Castellano, Cristina Lopez, Eva Gine, Santiago Demajo, Pedro Jares, Jose Martin-Subero, Silvia Bea, Elias Campo, Virginia Amador
Summary: SOX11 overexpression is associated with aggressive behavior in mantle cell lymphomas (MCL). This study finds that SOX11+ MCL cases show enrichment in gene signatures related to leukemic and hematopoietic stem cells, and Musashi-2 (MSI2) is identified as one of the upregulated stem cell-related genes. SOX11 directly binds to the MSI2 promoter and upregulates MSI2 expression. MSI2 upregulation is independently associated with poor overall survival in MCL, and its knockdown leads to decreased expression of genes related to apoptosis and stem cell features, reduced clonogenic growth, tumor cell survival, and chemoresistance in MCL cells.
Review
Oncology
Kenza Dubois, Mariana Tannoury, Brigitte Bauvois, Santos A. Susin, Delphine Garnier
Summary: Chronic lymphocytic leukemia (CLL) is a type of cancer characterized by the accumulation of abnormal B lymphocytes in the immune system. Despite the development of new therapies, drug resistance and disease relapse still occur. The interactions between leukemic B cells and the microenvironment play a crucial role in treatment resistance. Extracellular vesicles released into the microenvironment have emerged as key players in this cross-talk and can potentially be targeted for novel therapeutics.
Article
Oncology
Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn, Jamie Lees, Jennifer Cassels, Jiatian Li, Rinako Nakagawa, Owen J. Sansom, Alison M. Michie
Summary: This study reveals the essential role of mTORC1 in the initiation/maintenance of leukemia in a CLL model and identifies the inactivation of eEF2 activity as a novel therapeutic target for blocking CLL progression.
Article
Biochemistry & Molecular Biology
Kristan V. Piroeva, Charlotte Mcdonald, Charalampos Xanthopoulos, Chelsea Fox, Christopher T. Clarkson, Jan-Philipp Mallm, Yevhen Vainshtein, Luminita Ruje, Lara C. Klett, Stephan Stilgenbauer, Daniel Mertens, Efterpi Kostareli, Karsten Rippe, Vladimir B. Teif
Summary: This study compared the nucleosome positions in chronic lymphocytic leukemia (CLL) patients and healthy individuals, and found significant changes in nucleosome positioning in CLL. The spacing between nucleosomes was shortened, and changes in nucleosome occupancy were linked to chromatin remodeling and reduced DNA methylation. Nucleosome positioning can be used to classify CLL subtypes and monitor disease progression.
Review
Cell Biology
Yen-Liang Li, Wen-Chun Hung
Summary: Lymphatic metastasis is a major cause of cancer-related deaths, and the molecular basis of this process is not well understood. Cancer cells invade the lymphatic system and enter the sentinel lymph node, where they modify the microenvironment and suppress anti-tumor immunity. Developing strategies to reverse these changes in the sentinel lymph node may reduce colonization and distant metastasis. Alternatively, nanotechnology-based approaches for targeted drug delivery to the lymph node could enhance the efficacy of cancer treatment by killing cancer cells on site and promoting antigen presentation for immune activation.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Oncology
Marina Gerousi, Fotis Psomopoulos, Konstantia Kotta, Maria Tsagiopoulou, Niki Stavroyianni, Achilles Anagnostopoulos, Athanasios Anastasiadis, Maria Gkanidou, Ioannis Kotsianidis, Stavroula Ntoufa, Kostas Stamatopoulos
Summary: The study found that the calcitriol/VDR system is functional in CLL, regulating key signaling pathways for cell survival and proliferation. Microenvironmental signals can modulate VDR expression and function, but calcitriol acts independently, suggesting a potential clinical utility of vitamin D supplementation in CLL patients.
Article
Immunology
Giovanna Merchand-Reyes, Ramasamy Santhanam, Frank H. Robledo-Avila, Christoph Weigel, Juan De Dios Ruiz-Rosado, Xiaokui Mo, Santiago Partida-Sanchez, Jennifer A. Woyach, Christopher C. Oakes, Susheela Tridandapani, Jonathan P. Butchar
Summary: The development of nurse-like cells (NLCs) in chronic lymphocytic leukemia (CLL) depends on MEK signaling, and inhibition of MEK can slow down CLL progression and increase survival time in vivo. Targeting the MEK/ERK pathway may be an effective treatment strategy for CLL.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Management
Anup Kumar, Sudhanshu Joshi, Manu Sharma, Neeraj Vishvakarma
Summary: This study examines the impact of the dynamic capabilities of humanitarian organizations on disaster risk reduction, using the resource-based view and dynamic capability theory.
JOURNAL OF HUMANITARIAN LOGISTICS AND SUPPLY CHAIN MANAGEMENT
(2022)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Biochemistry & Molecular Biology
Stefanie N. Sveiven, Kyle Anesko, Joshua Morgan, Meera G. Nair, Tara M. Nordgren
Summary: The impact of pulmonary free fatty acid receptor 4 (FFAR4) on the pulmonary immune response and return to homeostasis was investigated using a human pulmonary immunogenic exposure model. Results showed that the anti-inflammatory effects of docosahexaenoic acid (DHA) were independent of FFAR4 expression. Mice lacking FFAR4 had reduced immune cells in the airways, epithelial dysplasia, and impaired pulmonary barrier integrity, indicating the potential therapeutic role of FFAR4 in pulmonary diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Oncology
Elisabeth Gross, Ralf-Axel Hilger, Franziska Lea Schuemann, Marcus Bauer, Alyssa Bouska, Christian Rohde, Edith Willscher, Jana Luetzkendorf, Lutz Peter Mueller, Bayram Edemir, Thomas Mueller, Marco Herling, Mascha Binder, Claudia Wickenhauser, Javeed Iqbal, Guido Posern, Thomas Weber
Summary: Histone lysine methyltransferase EZH2 is frequently altered in lymphoid tumors, and its overexpression or mutation is associated with tumor progression and resistance to chemotherapy. In this study, the combination treatment with SAM-competitive EZH2 inhibitors led to platinum resistance due to increased platinum efflux. Off-target effects of the inhibitors resulted in the upregulation of proteins associated with chemotherapy resistance.
Article
Oncology
Moritz Otte, Johanna Stachelscheid, Markus Glass, Linus Wahnschaffe, Qu Jiang, Waseem Lone, Aleksandr Ianevski, Tero Aittokallio, Javeed Iqbal, Michael Hallek, Stefan Huettelmaier, Alexandra Schrader, Till Braun, Marco Herling
Summary: T-prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell leukemia. Elevated expression of miR-141/200c cluster in T-PLL cells promotes cell proliferation and alters the expression of genes involved in cell survival and differentiation. Low expression of STAT4, a target gene of miR-141/200c, is associated with an immature phenotype of T-PLL cells and shortened overall survival of T-PLL patients. This study reveals the oncogenic role of miR-141/200c-STAT4 signaling pathway in T-PLL, shedding light on the involvement of non-protein-coding genes in the pathogenesis of this devastating disease.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Management
Saket Shanker, Akhilesh Barve, Kamalakanta Muduli, Anil Kumar, Jose Arturo Garza-Reyes, Sudhanshu Joshi
Summary: This study aims to analyze the factors influencing perishable food supply chains during the pandemic and improve their resiliency. The research revealed that factors like import-export restrictions and fear of violating social distancing guidelines are primary factors causing disruptions, while price fluctuations of perishable products and panic buying are crucial effects impacting perishable food supply chains.
INTERNATIONAL JOURNAL OF LOGISTICS-RESEARCH AND APPLICATIONS
(2022)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)