CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

Sulfated glycans control lymphocyte homing

(2012) Hiroto Kawashima et al.   Annals of the New York Academy of Sciences

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor

(2012) N. Reinart et al.   BLOOD

Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells

(2012) Emma Hamilton et al.   BRITISH JOURNAL OF HAEMATOLOGY

CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts

(2012) Hao Qian et al.   CANCER BIOLOGY & THERAPY

Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options

(2012) Valentina Audrito et al.   CANCER LETTERS

Global Quantitative Phosphoproteome Analysis of Human Tumor Xenografts Treated with a CD44 Antagonist

(2012) S. Weigand et al.   CANCER RESEARCH

Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia

(2012) M Sivina et al.   LEUKEMIA

ZAP-70 enhances migration of malignant B lymphocytes toward CCL21 by inducing CCR7 expression via IgM-ERK1/2 activation

(2011) E. Calpe et al.   BLOOD

Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

(2011) Andrea G. S. Buggins et al.   BRITISH JOURNAL OF HAEMATOLOGY

Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1

(2011) Yair Herishanu et al.   LEUKEMIA & LYMPHOMA

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1

(2010) Misato Hashizume et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the E - TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

(2010) M. Suljagic et al.   BLOOD

Potential role of serum level of soluble CD44 and IFN-γ in B-cell chronic lymphocytic leukemia

(2010) Nervana Samy et al.   MEDICAL ONCOLOGY

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia

(2009) M. Herling et al.   BLOOD

The microenvironment in mature B-cell malignancies: a target for new treatment strategies

(2009) J. A. Burger et al.   BLOOD

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

(2009) B. P. Toole   CLINICAL CANCER RESEARCH

Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib

(2009) Ansgar Brüning et al.   INVESTIGATIONAL NEW DRUGS

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

(2008) C. Pepper et al.   BLOOD

 4 1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells

(2008) J. Redondo-Munoz et al.   BLOOD

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

(2008) M. Hallek et al.   BLOOD

Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance

(2008) Bryan P. Toole et al.   DRUG RESISTANCE UPDATES

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD