Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells

(2014) A. E. Vilgelm et al.   CANCER RESEARCH

AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment

(2014) Emilia Caputo et al.   Journal of Translational Medicine

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

MTSS1 is a metastasis driver in a subset of human melanomas

(2014) Kirsten D. Mertz et al.   Nature Communications

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

NEDD9 Depletion Destabilizes Aurora A Kinase and Heightens the Efficacy of Aurora A Inhibitors: Implications for Treatment of Metastatic Solid Tumors

(2013) R. J. Ice et al.   CANCER RESEARCH

Treatment of BRAF-Mutant Melanoma: The Role of Vemurafenib and Other Therapies

(2013) S Jang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

(2013) Cory M. Johannessen et al.   NATURE

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

(2013) Meghna Das Thakur et al.   NATURE

A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF

(2013) V Borgdorff et al.   ONCOGENE

Aurora B Is Regulated by the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (MAPK/ERK) Signaling Pathway and Is a Valuable Potential Target in Melanoma Cells

(2012) Caroline Bonet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of CRM1-Mediated Nucleocytoplasmic Transport: Triggering Human Melanoma Cell Apoptosis by Perturbing Multiple Cellular Pathways

(2012) Gaurav Pathria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

(2012) Michael P. Smith et al.   JNCI-Journal of the National Cancer Institute

Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma

(2012) Ahmad Jalili et al.   JNCI-Journal of the National Cancer Institute

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

(2011) Nikhil Wagle et al.   JOURNAL OF CLINICAL ONCOLOGY

Polo-Like Kinase 1 Is a Potential Therapeutic Target in Human Melanoma

(2011) Ahmad Jalili et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death

(2011) V Ratushny et al.   ONCOGENE

A picture of Mitf in melanoma immortality

(2011) C R Goding   ONCOGENE

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

(2010) G. Gorgun et al.   BLOOD

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

(2010) Jessie Villanueva et al.   CANCER CELL

An Integrated Approach to Uncover Drivers of Cancer

(2010) Uri David Akavia et al.   CELL

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

Aurora Kinase A Inhibition Leads to p73-Dependent Apoptosis in p53-Deficient Cancer Cells

(2008) Altaf A. Dar et al.   CANCER RESEARCH

Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases

(2008) L. Xu et al.   MOLECULAR CANCER RESEARCH

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

(2008) Claudia Wellbrock et al.   PLoS One