Development and design of the tertiary amino effect reaction for DNA-encoded library synthesis

Chemical Biology Probes from Advanced DNA-encoded Libraries

(2016) Hazem Salamon et al.   ACS Chemical Biology

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

(2016) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

DNA tags help the hunt for drugs

(2016) Asher Mullard   NATURE

Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library

(2015) Raphael M. Franzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries

(2015) Alexander Lee Satz et al.   BIOCONJUGATE CHEMISTRY

The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity

(2015) Benjamin A. Seigal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

(2015) Gregory S. Basarab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

(2015) Hongfang Yang et al.   ACS Medicinal Chemistry Letters

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library

(2015) Hongfeng Deng et al.   ACS Medicinal Chemistry Letters

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

(2015) Gregory S. Basarab et al.   Scientific Reports

Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

(2014) Christopher S. Kollmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A DNA-templated synthesis of encoded small molecules by DNA self-assembly

(2014) Cheng Cao et al.   CHEMICAL COMMUNICATIONS

Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

(2014) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Robust Suzuki–Miyaura Cross-Coupling on DNA-Linked Substrates

(2014) Yun Ding et al.   ACS Combinatorial Science

tert-Amino effect: the Meth-Cohn and Reinhoudt reactions (Review)

(2013) A. Yu. Platonova et al.   Chemistry of Heterocyclic Compounds

Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

(2013) Jeremy S. Disch et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor

(2013) Patricia L. Podolin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics

(2012) Bernardas Morkunas et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

20 years of DNA-encoded chemical libraries

(2011) Luca Mannocci et al.   CHEMICAL COMMUNICATIONS

From molecule to model, from environment to evolution: an integrated view of growth and development

(2010) Dominique C Bergmann et al.   CURRENT OPINION IN PLANT BIOLOGY

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions

(2008) Fabian Buller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable forin VitroSelection

(2008) Brian N. Tse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic Acids and Their Heterocyclic Analogs

(2008) Sergey V. Ryabukhin et al.   SYNTHETIC COMMUNICATIONS