β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

Heat shock response and autophagy—cooperation and control

(2015) Karol Dokladny et al.   Autophagy

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

CDK5 Knockdown Prevents Hippocampal Degeneration and Cognitive Dysfunction Produced by Cerebral Ischemia

(2015) Johana A Gutiérrez-Vargas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer’s disease animal models

(2015) Javier G. Villamil-Ortiz et al.   Frontiers in Aging Neuroscience

Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β

(2014) Jeremy H Toyn et al.   Alzheimers Research & Therapy

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice

(2014) John F. Castro-Alvarez et al.   Frontiers in Aging Neuroscience

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Silencing of Hsp90 Chaperone Expression Protects Against 6-Hydroxydopamine Toxicity in PC12 Cells

(2013) Behrang Alani et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protein rescue from aggregates by powerful molecular chaperone machines

(2013) Shannon M. Doyle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

(2012) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

(2011) Umesh K. Jinwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling

(2011) Li-Ming Chen et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

mTORC1 Links Protein Quality and Quantity Control by Sensing Chaperone Availability

(2010) Shu-Bing Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

(2010) D. Piedrahita et al.   JOURNAL OF NEUROSCIENCE

Characterization of the B-Raf interactome in mouse hippocampal neuronal cells

(2010) Juan J. Bonfiglio et al.   Journal of Proteomics

4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A2 in cultured Ra2 microglial cells via MAPK pathways

(2010) Noriyuki Shibata et al.   NEUROPATHOLOGY

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

BAG-1M is up-regulated in hippocampus of Alzheimer’s disease patients and associates with tau and APP proteins

(2009) Evan Elliott et al.   JOURNAL OF NEUROCHEMISTRY

Mild cholesterol depletion reduces amyloid-β production by impairing APP trafficking to the cell surface

(2009) Cristina Guardia-Laguarta et al.   JOURNAL OF NEUROCHEMISTRY

BACE1 and BACE2 enzymatic activities in Alzheimer’s disease

(2009) Rachel R. Ahmed et al.   JOURNAL OF NEUROCHEMISTRY

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

(2009) D. C. Carrettiero et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells

(2009) Akiko Oda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

(2009) Ryan L Boudreau et al.   MOLECULAR THERAPY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol

(2009) Kumiko Makide et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

(2008) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats

(2008) Y.-J. Zhang et al.   JOURNAL OF NEURAL TRANSMISSION

Blocking A 42 Accumulation Delays the Onset and Progression of Tau Pathology via the C Terminus of Heat Shock Protein70-Interacting Protein: A Mechanistic Link between A  and Tau Pathology

(2008) S. Oddo et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment

(2008) Kang Soo Lee et al.   NEUROSCIENCE LETTERS

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE